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1.
J Enzyme Inhib Med Chem ; 31(6): 1102-10, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26497704

RESUMO

Three salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole (Hats) were prepared and characterized by physico-chemical methods. The p-toluensulfonate, the methylsulfonate, and the chlorhydrate monohydrate salts of Hats were evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs) and as anticonvulsants and diuretics, since many CAIs are clinically used as pharmacological agents. The three Hats salts exhibited diuretic and anticonvulsant activities with little neurotoxicity. The human (h) isoforms hCA I, II, IV, VII, IX, and XII were inhibited in their micromolar range by these salts, whereas pathogenic beta and gamma CAs showed similar, weak inhibitory profiles.


Assuntos
Acetazolamida/análogos & derivados , Anticonvulsivantes/farmacologia , Inibidores da Anidrase Carbônica/farmacologia , Diuréticos/farmacologia , Sulfonamidas/química , Tiadiazóis/farmacologia , Anticonvulsivantes/química , Inibidores da Anidrase Carbônica/química , Diuréticos/química , Humanos , Isoenzimas/antagonistas & inibidores , Tiadiazóis/química
2.
Pharm Biol ; 49(7): 675-8, 2011 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-21609303

RESUMO

CONTEXT: Cyclolepis genistoides D. Don (Asteraceae) is an Argentinean endemic shrub, known by the vernacular name "palo azul" or "matorro negro". It is widely used in folk medicine as a diuretic, an antirheumatic, and an antispasmodic agent. OBJECTIVE: The aim of this work was to describe the activity of two isolated compounds of C. genistoides, oleanolic acid (1) and deacylcynaropicrin (2), using the carrageenan-induced paw edema method in mice. MATERIALS AND METHODS: Aerial parts of C. genistoides were dried, powdered, and extracted with petroleum ether, ethyl acetate, dichloromethane, and methanol for 48 h. The fractions obtained from the ethyl acetate extract yielded oleanolic acid, while deacylcynaropicrin was obtained according to Abdei-Mogib et al. Structures were elucidated by ¹H-NMR and ¹³C-NMR. The products were administered intraperitoneally at doses of 40, 75, and 100 mg/kg. RESULTS AND DISCUSSION: Compound 1 exhibited significant activity during the first 7 h of the inflammatory phase (at 1, 3, 5, and 7 h), exercising its inhibitory action on inflammation mediated by histamine, prostaglandins, serotonin, and kinins, while compound 2 showed a significant inhibition at 3 and 5 h contributing to this effect, acting in the intermediate phase. CONCLUSIONS: According to the results of this work, the intraperitoneal administration of oleanolic acid and deacylcynaropicrin isolated from the aerial parts of C. genistoides produced a significant inhibition of carrageenan-induced inflammation at doses of 75 and 100 mg/kg. These results give support to the use of this plant as an anti-inflammatory in traditional medicine.


Assuntos
Anti-Inflamatórios/farmacologia , Asteraceae/química , Lactonas/farmacologia , Ácido Oleanólico/farmacologia , Sesquiterpenos/farmacologia , Animais , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/isolamento & purificação , Carragenina , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Feminino , Inflamação/tratamento farmacológico , Inflamação/fisiopatologia , Injeções Intraperitoneais , Lactonas/administração & dosagem , Lactonas/isolamento & purificação , Masculino , Medicina Tradicional , Camundongos , Ácido Oleanólico/administração & dosagem , Ácido Oleanólico/isolamento & purificação , Componentes Aéreos da Planta , Extratos Vegetais/administração & dosagem , Extratos Vegetais/farmacologia , Sesquiterpenos/administração & dosagem , Sesquiterpenos/isolamento & purificação , Fatores de Tempo
3.
Farmaco ; 59(4): 245-54, 2004 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-15081341

RESUMO

As part of our project devoted to the search of new antifungal agents, we report here the in vitro-in vivo antifungal evaluations and a structure-activity relationship (SAR) study of 17 thione derivatives. Some compounds of this series exhibited remarkable antifungal activity against a broad spectrum of pathogenic opportunistic fungi. SAR studies provide a useful information for the determination of the minimum structural requirements for producing the biological response.


Assuntos
Antifúngicos/química , Tionas/química , Tiofenos/química , Animais , Antifúngicos/uso terapêutico , Cobaias , Humanos , Testes de Sensibilidade Microbiana/estatística & dados numéricos , Relação Estrutura-Atividade , Tionas/uso terapêutico , Tiofenos/uso terapêutico , Tinha/tratamento farmacológico , Trítio/química
4.
Food Chem Toxicol ; 50(3-4): 672-4, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22240414

RESUMO

The dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana Besser which is used in popular medicine. Toxicity tests using embryos of amphibian have been widely used in order to predict toxic effects of different compounds. However, to our knowledge, there are not studies focussed on the toxic effects of dehydroleucodine on Bufo arenarum, which is an anuran widely distributed in South America. The effect of dehydroleucodine on the survival of embryos was evaluated in an acute test during the early life stage of B. arenarum embryos. Lethality and the degree of adverse effects were dehydroleucodine dose-dependent. Overall, amphibian early life stages appeared to be more susceptible to the embryotoxicity associated with exposure to dehydroleucodine, especially at concentration greater that 3mM. This increased susceptibility may result from the relatively high rate of cellular differentiation and morphogenesis that occurs at this early stage of development.


Assuntos
Bufo arenarum/embriologia , Embrião não Mamífero/efeitos dos fármacos , Lactonas/toxicidade , Sesquiterpenos/toxicidade , Animais , Relação Dose-Resposta a Droga
5.
Pharmacol Res ; 48(6): 601-6, 2003 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-14527825

RESUMO

The anti-inflammatory activities of flavonols (quercetin, rutin and morin) and flavanones (hesperetin and hesperidin) were investigated in animal models of acute and chronic inflammation. Rutin was only effective in the chronic process, principally in adjuvant arthritis. On neurogenic inflammation induced by xylene, only the flavanones were effective; besides, these compounds were the most effective on subchronic process. The most important compound in reducing paw oedema induced by carrageenan was quercetin.


Assuntos
Flavonoides/uso terapêutico , Inflamação/prevenção & controle , Animais , Artrite Experimental/prevenção & controle , Carragenina , Modelos Animais de Doenças , Orelha/patologia , Edema/induzido quimicamente , Edema/prevenção & controle , Flavonoides/química , Hesperidina/química , Hesperidina/uso terapêutico , Membro Posterior/patologia , Inflamação/induzido quimicamente , Camundongos , Estrutura Molecular , Quercetina/química , Quercetina/uso terapêutico , Distribuição Aleatória , Ratos , Ratos Wistar , Rutina/química , Rutina/uso terapêutico , Xilenos
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