Detalhe da pesquisa
1.
The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action.
Genes Dev
; 32(3-4): 309-320, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29491137
2.
Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists.
J Biol Chem
; 298(11): 102539, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36179791
3.
Combined inhibition of FGFR4 and VEGFR signaling enhances efficacy in FGF19 driven hepatocellular carcinoma.
Am J Cancer Res
; 12(6): 2733-2743, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35812049
4.
Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3.
ACS Med Chem Lett
; 12(1): 93-98, 2021 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33488969
5.
Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators.
Nat Commun
; 10(1): 137, 2019 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30635584
6.
H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.
Nat Med
; 24(4): 497-504, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29457796
7.
Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer.
Cancer Discov
; 8(9): 1176-1193, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29991605
8.
H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma.
Cancer Res
; 77(24): 6999-7013, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29247039
9.
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Nat Commun
; 8: 15522, 2017 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28541300
10.
Total synthesis of 6-deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 cancer cell line.
Org Lett
; 16(21): 5560-3, 2014 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25376106
11.
Cyst wall synthase: N-acetylgalactosaminyltransferase activity is induced to form the novel N-acetylgalactosamine polysaccharide in the Giardia cyst wall.
Microbiology (Reading)
; 150(Pt 5): 1237-1243, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15133086
12.
The Giardia intestinalis filamentous cyst wall contains a novel beta(1-3)-N-acetyl-D-galactosamine polymer: a structural and conformational study.
Glycobiology
; 12(8): 499-505, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12145190