Detalhe da pesquisa
1.
Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.
Proc Natl Acad Sci U S A
; 117(29): 17296-17307, 2020 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32631998
2.
Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.
Acta Neuropathol
; 141(4): 547-564, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33641009
3.
Evaluation of ABT-888 in the amelioration of α-synuclein fibril-induced neurodegeneration.
Brain Commun
; 4(2): fcac042, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35282165
4.
Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain.
Mol Neurodegener
; 17(1): 7, 2022 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35012605
5.
Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity.
J Parkinsons Dis
; 12(5): 1423-1447, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35599495
6.
Genetic background influences LRRK2-mediated Rab phosphorylation in the rat brain.
Brain Res
; 1759: 147372, 2021 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33600829
7.
Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein.
Acta Neuropathol Commun
; 9(1): 180, 2021 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34749824
8.
Pharmacodynamic Biomarkers for Emerging LRRK2 Therapeutics.
Front Neurosci
; 14: 807, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32903744
9.
Exosome markers of LRRK2 kinase inhibition.
NPJ Parkinsons Dis
; 6(1): 32, 2020 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33298972
10.
The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition.
Exp Neurol
; 309: 1-13, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30048714