Detalhe da pesquisa
1.
The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease.
Bioorg Med Chem Lett
; 28(1): 43-48, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29162454
2.
P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor.
Bioorg Med Chem Lett
; 28(10): 1853-1859, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29650290
3.
Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus.
Bioorg Med Chem Lett
; 27(3): 590-596, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28011221
4.
Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase.
Bioorg Med Chem Lett
; 27(15): 3294-3300, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28633899
5.
Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase.
Bioorg Med Chem Lett
; 26(3): 936-940, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26747393
6.
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect.
Nature
; 465(7294): 96-100, 2010 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-20410884
7.
Preclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase.
Antimicrob Agents Chemother
; 58(6): 3485-95, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24733465
8.
Identification of a novel series of potent HCV NS5B Site I inhibitors.
Bioorg Med Chem Lett
; 24(8): 1993-7, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24656612
9.
HCV NS5A replication complex inhibitors. Part 5: discovery of potent and pan-genotypic glycinamide cap derivatives.
Bioorg Med Chem Lett
; 23(15): 4428-35, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23803586
10.
Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032).
Antimicrob Agents Chemother
; 56(10): 5387-96, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22869577
11.
HCV NS5A replication complex inhibitors. Part 2: investigation of stilbene prolinamides.
Bioorg Med Chem Lett
; 22(19): 6063-6, 2012 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22959243
12.
Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: potent allosteric inhibitors of the hepatitis C virus NS5B polymerase.
Bioorg Med Chem Lett
; 22(8): 2866-71, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22424979
13.
Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.
Bioorg Med Chem Lett
; 21(10): 2925-9, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21486696
14.
An automated liquid chromatography-mass spectrometry process to determine metabolic stability half-life and intrinsic clearance of drug candidates by substrate depletion.
Assay Drug Dev Technol
; 6(1): 121-9, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18336089
15.
Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor.
ACS Med Chem Lett
; 9(2): 143-148, 2018 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456803
16.
Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.
J Med Chem
; 60(10): 4369-4385, 2017 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28430437
17.
Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.
J Med Chem
; 59(17): 8042-60, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27564532
18.
Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor.
J Pharm Sci
; 104(9): 2813-23, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25631585
19.
Synthesis and structure-activity relationships of 3-aryloxindoles: a new class of calcium-dependent, large conductance potassium (maxi-K) channel openers with neuroprotective properties.
J Med Chem
; 45(7): 1487-99, 2002 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-11906290
20.
Preclinical pharmacokinetics and in vitro metabolism of BMS-605339: a novel HCV NS3 protease inhibitor.
J Pharm Sci
; 103(6): 1891-902, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24700293