Detalhe da pesquisa
1.
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Nature
; 629(8013): 919-926, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38589574
2.
Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.
Cancer Discov
; : OF1-OF24, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38593348
3.
Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
J Med Chem
; 66(1): 149-169, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36533617
4.
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS.
Science
; 381(6659): 794-799, 2023 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37590355
5.
Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography.
Sci Rep
; 9(1): 15450, 2019 10 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31664082
6.
Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis.
J Antimicrob Chemother
; 62(4): 713-9, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18587134
7.
Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.
Bioorg Med Chem Lett
; 18(7): 2256-62, 2008 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18358721
8.
Peptide inhibitors of West Nile NS3 protease: SAR study of tetrapeptide aldehyde inhibitors.
J Med Chem
; 49(22): 6585-90, 2006 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17064076
9.
Finding new medicines for flaviviral targets.
Novartis Found Symp
; 277: 102-14; discussion 114-9, 251-3, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-17319157
10.
Synthesis, structure, and molecular orbital calculations of chromium(III) and iron(III) complexes containing eta2-pyrazolato ligands.
Angew Chem Int Ed Engl
; 41(9): 1591-4, 2002 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19750676
11.
Yellow fever virus NS3 protease: peptide-inhibition studies.
J Gen Virol
; 88(Pt 8): 2223-2227, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17622626
12.
Chemical failure modes of AlQ3-based OLEDs: AlQ3 hydrolysis.
Phys Chem Chem Phys
; 8(12): 1371-7, 2006 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16633618
13.
Experimental and theoretical study of the coordination of 1,2,4-triazolato, tetrazolato, and pentazolato ligands to the [K(18-crown-6)]+ fragment.
Inorg Chem
; 45(21): 8700-10, 2006 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17029381
14.
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.
Bioorg Med Chem Lett
; 16(1): 40-3, 2006 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16246563
15.
Weak carbon-hydrogen-nitrogen interactions affect the heterocyclic ligand bonding modes in barium complexes containing eta2-tetrazolato and eta2-pentazolato ligands.
Inorg Chem
; 44(14): 4894-6, 2005 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-15998011
16.
Synthesis, structure, bridge-terminal exchange kinetics, and molecular orbital calculations of pyrazolate-bridged digallium complexes containing bridging phenyl groups.
J Am Chem Soc
; 125(37): 11152-3, 2003 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-16220909