Detalhe da pesquisa
1.
In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3' and 5' thiophosphate linkages.
Nucleic Acids Res
; 48(1): 63-74, 2020 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31754711
2.
Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice.
Nucleic Acids Res
; 46(11): 5366-5380, 2018 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29790953
3.
Managing the sequence-specificity of antisense oligonucleotides in drug discovery.
Nucleic Acids Res
; 45(5): 2262-2282, 2017 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28426096
4.
Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells.
Mol Ther
; 24(6): 1117-1125, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26961407
5.
A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells.
Nucleic Acids Res
; 43(19): 9350-61, 2015 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26433227
6.
The synergism of MCL1 and glycolysis on pediatric acute lymphoblastic leukemia cell survival and prednisolone resistance.
Haematologica
; 98(12): 1905-11, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24142999
7.
PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates.
Mol Ther
; 20(2): 376-81, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22108858
8.
Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents.
Nucleic Acids Res
; 38(1): e3, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19854938
9.
Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.
Nucleic Acids Res
; 38(20): 7100-11, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20615897
10.
Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers.
Mol Ther Nucleic Acids
; 29: 176-188, 2022 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35860384
11.
In vivo uptake of antisense oligonucleotide drugs predicted by ab initio quantum mechanical calculations.
Sci Rep
; 11(1): 6321, 2021 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33737567
12.
A Multifunctional LNA Oligonucleotide-Based Strategy Blocks AR Expression and Transactivation Activity in PCa Cells.
Mol Ther Nucleic Acids
; 23: 63-75, 2021 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33335793
13.
Refining LNA safety profile by controlling phosphorothioate stereochemistry.
PLoS One
; 15(6): e0232603, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32530964
14.
Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides Allows Optimization of Pharmaceutical Properties.
Mol Ther Nucleic Acids
; 19: 706-717, 2020 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31951854
15.
Targeting Repeated Regions Unique to a Gene Is an Effective Strategy for Discovering Potent and Efficacious Antisense Oligonucleotides.
Mol Ther Nucleic Acids
; 19: 124-131, 2020 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31846799
16.
Nuclear and Cytoplasmatic Quantification of Unconjugated, Label-Free Locked Nucleic Acid Oligonucleotides.
Nucleic Acid Ther
; 30(1): 4-13, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31618108
17.
Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides.
Mol Ther Nucleic Acids
; 19: 1290-1298, 2020 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32092825
18.
Locked nucleic acid aptamers.
Methods Mol Biol
; 535: 165-86, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19377996
19.
SPC3042: a proapoptotic survivin inhibitor.
Mol Cancer Ther
; 7(9): 2736-45, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18790754
20.
Identifying Suitable Target Regions and Analyzing Off-Target Effects of Therapeutic Oligonucleotides.
Methods Mol Biol
; 2036: 261-282, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31410803