Detalhe da pesquisa
1.
Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11.
Proc Natl Acad Sci U S A
; 119(28): e2122840119, 2022 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35867762
2.
Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes.
Basic Res Cardiol
; 119(1): 151-168, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38145999
3.
Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34544857
4.
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
Nat Immunol
; 12(3): 222-30, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21151103
5.
Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis.
Eur Respir J
; 59(4)2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34561286
6.
TSC2 regulates microRNA biogenesis via mTORC1 and GSK3ß.
Hum Mol Genet
; 27(9): 1654-1663, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29509898
7.
New developments in the genetics and pathogenesis of tumours in tuberous sclerosis complex.
J Pathol
; 241(2): 219-225, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27753446
8.
Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization.
Am J Pathol
; 186(12): 3261-3272, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27768862
9.
Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema.
Proc Natl Acad Sci U S A
; 107(44): 18880-5, 2010 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20956295
10.
TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema.
Am J Physiol Lung Cell Mol Physiol
; 303(9): L748-57, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22983353
11.
Spectrum of germline and somatic mitochondrial DNA variants in Tuberous Sclerosis Complex.
Front Genet
; 13: 917993, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36793390
12.
Drug Inhibition of Redox Factor-1 Restores Hypoxia-Driven Changes in Tuberous Sclerosis Complex 2 Deficient Cells.
Cancers (Basel)
; 14(24)2022 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36551683
13.
TSC2 Interacts with HDLBP/Vigilin and Regulates Stress Granule Formation.
Mol Cancer Res
; 19(8): 1389-1397, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33888601
14.
TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism.
Nat Commun
; 12(1): 4245, 2021 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34253722
15.
Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex.
Cancer Res
; 81(8): 2086-2100, 2021 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33593821
16.
mTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury.
JCI Insight
; 6(14)2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34138757
17.
Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor ß (RARß).
Oncogene
; 38(49): 7367-7383, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31420607
18.
Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion.
J Exp Med
; 216(11): 2635-2652, 2019 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31506280
19.
Renal disease in tuberous sclerosis complex: pathogenesis and therapy.
Nat Rev Nephrol
; 14(11): 704-716, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30232410
20.
Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis.
Sci Rep
; 8(1): 14161, 2018 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30242175