Detalhe da pesquisa
1.
Ticagrelor vs placebo for the reduction of vaso-occlusive crises in pediatric sickle cell disease: the HESTIA3 study.
Blood
; 140(13): 1470-1481, 2022 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35849650
2.
Combination Treatment with Verinurad and Allopurinol in CKD: A Randomized Placebo and Active Controlled Trial.
J Am Soc Nephrol
; 35(5): 594-606, 2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38564654
3.
Results of a Doravirine-Atorvastatin Drug-Drug Interaction Study.
Antimicrob Agents Chemother
; 61(2)2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27872071
4.
3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization.
Bioorg Med Chem Lett
; 19(9): 2524-9, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19328692
5.
3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators.
Bioorg Med Chem Lett
; 18(20): 5493-6, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18812259
6.
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate.
J Med Chem
; 61(3): 1001-1018, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29293004
7.
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
J Med Chem
; 60(13): 5673-5698, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28574706
8.
An efficient alternative route to 3,6-disubstituted-furo[2,3-d]pyrimidin-2-one analogues.
Nucleosides Nucleotides Nucleic Acids
; 24(10-12): 1729-43, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16438044
9.
Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
J Med Chem
; 61(8): 3753, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29624389
10.
1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis.
J Med Chem
; 54(6): 1724-39, 2011 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21366332
11.
Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.
J Med Chem
; 53(3): 1222-37, 2010 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20043678
12.
Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors.
J Med Chem
; 52(11): 3576-85, 2009 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19438227