Detalhe da pesquisa
1.
Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.
Antimicrob Agents Chemother
; 68(4): e0137323, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38380945
2.
Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation.
J Hepatol
; 73(4): 896-905, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32376414
3.
Hepatitis B Virus X Protein Function Requires Zinc Binding.
J Virol
; 93(16)2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31167910
4.
Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).
Proc Natl Acad Sci U S A
; 113(33): 9274-9, 2016 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27489345
5.
Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).
Bioorg Med Chem Lett
; 28(3): 541-546, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29254643
6.
Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247.
FASEB J
; 29(1): 70-80, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25351987
7.
4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms.
J Biol Chem
; 289(35): 24533-48, 2014 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24970894
8.
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.
Nucleic Acids Res
; 40(1): 345-59, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21908397
9.
HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors.
J Biol Chem
; 287(35): 29988-99, 2012 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22761416
10.
Biochemical mechanism of HIV-1 resistance to rilpivirine.
J Biol Chem
; 287(45): 38110-23, 2012 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22955279
11.
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.
Retrovirology
; 10: 65, 2013 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23800377
12.
Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.
Antimicrob Agents Chemother
; 57(12): 6254-64, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24100493
13.
Evaluation of Combinations of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine with Clinically Used Antiretroviral Drugs.
Antimicrob Agents Chemother
; 57(9): 4554-4558, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23796932
14.
Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates.
Nucleic Acids Res
; 39(18): 8237-47, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21727088
15.
Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase.
Antimicrob Agents Chemother
; 56(4): 2048-61, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22252812
16.
Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis.
Hepatol Commun
; 6(9): 2298-2309, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35735253
17.
The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine.
J Biol Chem
; 285(49): 38700-9, 2010 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20876531
18.
Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.
Biochim Biophys Acta
; 1804(5): 1202-12, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19665597
19.
Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.
J Biol Chem
; 284(51): 35681-91, 2009 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19837673
20.
Impact of the translocational equilibrium of HIV-1 reverse transcriptase on the efficiency of mismatch extensions and the excision of mispaired nucleotides.
Int J Biochem Cell Biol
; 36(9): 1823-35, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15183347