Detalhe da pesquisa
1.
Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.
PLoS Biol
; 22(1): e3002462, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38289969
2.
RNA-binding properties orchestrate TDP-43 homeostasis through condensate formation in vivo.
Nucleic Acids Res
; 52(9): 5301-5319, 2024 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38381071
3.
Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1.
J Biol Chem
; 300(5): 107207, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38522514
4.
ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis.
Hum Mol Genet
; 32(14): 2386-2398, 2023 07 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37220877
5.
Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells.
J Cell Sci
; 133(15)2020 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32661089
6.
CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1.
J Biol Chem
; 294(10): 3744-3759, 2019 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30635404
7.
The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins.
Glia
; 68(2): 407-421, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31596526
8.
SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS.
J Cell Sci
; 131(11)2018 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29748379
9.
Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt Bridge Formation.
Anal Chem
; 92(2): 1702-1711, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31854977
10.
Rapid classification of a novel ALS-causing I149S variant in superoxide dismutase-1.
Amyotroph Lateral Scler Frontotemporal Degener
; : 1-7, 2024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38742757
11.
Amyloidogenic regions in beta-strands II and III modulate the aggregation and toxicity of SOD1 in living cells.
Open Biol
; 14(6): 230418, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38835240
12.
Protocol for the generation and automated confocal imaging of whole multi-cellular tumor spheroids.
STAR Protoc
; 4(2): 102331, 2023 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37300829
13.
Cells Overexpressing ALS-Associated SOD1 Variants Are Differentially Susceptible to CuATSM-Associated Toxicity.
ACS Chem Neurosci
; 13(16): 2371-2379, 2022 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35900338
14.
Assessment of protein inclusions in cultured cells using automated image analysis.
STAR Protoc
; 3(4): 101748, 2022 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36201320
15.
CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1G93A mice with a C57BL/6 background.
Sci Rep
; 11(1): 19392, 2021 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34588483
16.
Proteome Homeostasis Dysfunction: A Unifying Principle in ALS Pathogenesis.
Trends Neurosci
; 43(5): 274-284, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32353332
17.
Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises.
Front Cell Neurosci
; 14: 581907, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33328890
18.
Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS.
iScience
; 23(11): 101700, 2020 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33196025
19.
Thulium oxide nanoparticles as radioenhancers for the treatment of metastatic cutaneous squamous cell carcinoma.
Phys Med Biol
; 65(21): 215018, 2020 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32726756
20.
Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection.
PLoS One
; 15(1): e0227655, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31999698