Detalhe da pesquisa
1.
Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out.
SLAS Discov
; 27(6): 337-348, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35872229
2.
Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics.
J Comput Aided Mol Des
; 25(7): 621-36, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21604056
3.
Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure-Activity Relationships and Optimization.
J Med Chem
; 64(6): 3299-3319, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33666424
4.
High-throughput virtual screening of proteins using GRID molecular interaction fields.
J Chem Inf Model
; 50(1): 155-69, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19919042
5.
Discovery of a First-in-Class Potent Small Molecule Antagonist against the Adrenomedullin-2 Receptor.
ACS Pharmacol Transl Sci
; 3(4): 706-719, 2020 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32832872
6.
Pyrazole NNRTIs 3: optimisation of physicochemical properties.
Bioorg Med Chem Lett
; 19(19): 5603-6, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19717303
7.
Enhanced HTS hit selection via a local hit rate analysis.
J Chem Inf Model
; 49(10): 2202-10, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19795815
8.
N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.
Bioorg Med Chem Lett
; 18(15): 4308-11, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18625557
9.
Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents.
Bioorg Med Chem Lett
; 18(24): 6562-7, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18945617
10.
Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.
PLoS One
; 13(6): e0197372, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29856759
11.
Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor.
ACS Med Chem Lett
; 7(2): 134-8, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985287
12.
Computational tools for the analysis and visualization of multiple protein-ligand complexes.
J Mol Graph Model
; 24(3): 186-94, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16169759
13.
Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity.
J Med Chem
; 58(24): 9615-24, 2015 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26571076
14.
Continuing analysis of microRNA origins: Formation from transposable element insertions and noncoding RNA mutations.
Mob Genet Elements
; 3(6): e27755, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24475369
15.
Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.
PLoS Negl Trop Dis
; 6(4): e1625, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22545171