RESUMO
We studied the biodistribution of luminescent octahedral rhenium cluster complex K4[Re6S8(CN)6], a promising agent for photodynamic therapy. It was shown that rhenium complex [Re6S8(CN)6](4-)is mainly accumulated in the liver, the central organ of metabolism, and can be excreted by the kidneys. The cluster complex was also accumulated in the spleen in significant amount, which makes it a promising agent for creation of preparations for diagnostics and treatment of lymphoproliferative disorders. The mean lethal dose of the cluster complex was 0.38 g/kg.
Assuntos
Complexos de Coordenação/farmacocinética , Fármacos Fotossensibilizantes/farmacocinética , Animais , Complexos de Coordenação/toxicidade , Ensaios de Seleção de Medicamentos Antitumorais , Dose Letal Mediana , Fígado/metabolismo , Dose Máxima Tolerável , Fotoquimioterapia , Fármacos Fotossensibilizantes/toxicidade , Ratos , Ratos Wistar , Distribuição TecidualRESUMO
An abrupt change in internuclear Re-Re distances between {Re(6)} subunits in the carbon-centered [Re(12)mu(6)-CS(17)(CN)(6)](n-) complexes caused by the change of the oxidation state (n = 6, 8) is first theoretically shown to be possibly controlled by an external electric field. (13)C NMR signal is shown to change over ~400 ppm (~37G) for mu(6)-C atom together with n. Thereby, the metal cluster [Re(12)mu(6)-CS(17)(CN)(6)](n-) can be considered as a perspective model of a molecular switch.