1.
J Org Chem
; 87(6): 4460-4467, 2022 03 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35229594
RESUMO
Herein, we designed a simple nitrile synthesis from N-[(2-nitrophenyl)sulfonyl]benzamides via base-promoted intramolecular nucleophilic aromatic substitution. The process features redox-neutral conditions as well as no requirement of toxic cyanide species and transition metals. Our process shows broad scope and various functional group compatibility, affording a variety of (hetero)aromatic nitriles in good to excellent yields.