Detalhe da pesquisa
1.
Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder.
Cell
; 167(6): 1481-1494.e18, 2016 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27912058
2.
Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation.
J Pharmacol Sci
; 154(3): 182-191, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38395519
3.
Identification of tumor-suppressive miRNAs that target amino acid transporter LAT1 and exhibit anti-proliferative effects on cholangiocarcinoma cells.
J Pharmacol Sci
; 154(4): 301-311, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38485348
4.
Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells.
J Pharmacol Sci
; 155(1): 14-20, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38553134
5.
Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells.
Cancer Cell Int
; 23(1): 116, 2023 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37322479
6.
Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells.
J Cell Mol Med
; 26(20): 5246-5256, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36071551
7.
Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT10.
J Pharmacol Sci
; 150(1): 41-48, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-35926947
8.
Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor.
Cancer Sci
; 112(2): 871-883, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33264461
9.
Interaction of Halogenated Tyrosine/Phenylalanine Derivatives with Organic Anion Transporter 1 in the Renal Handling of Tumor Imaging Probes.
J Pharmacol Exp Ther
; 375(3): 451-462, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32981893
10.
Boron delivery for boron neutron capture therapy targeting a cancer-upregulated oligopeptide transporter.
J Pharmacol Sci
; 139(3): 215-222, 2019 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-30833090
11.
Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1.
Proc Natl Acad Sci U S A
; 113(3): 775-80, 2016 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26739563
12.
Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1).
J Pharmacol Sci
; 133(2): 96-102, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-28242177
13.
Specific transport of 3-fluoro-l-α-methyl-tyrosine by LAT1 explains its specificity to malignant tumors in imaging.
Cancer Sci
; 107(3): 347-52, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26749017
14.
Interaction of the Sodium/Glucose Cotransporter (SGLT) 2 inhibitor Canagliflozin with SGLT1 and SGLT2.
J Pharmacol Exp Ther
; 358(1): 94-102, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27189972
15.
Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling.
Amino Acids
; 48(4): 1045-1058, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26724922
16.
Transport of 3-fluoro-L-α-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [(18)F]FAMT positron emission tomography.
J Pharmacol Sci
; 130(2): 101-9, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26887331
17.
Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2.
Cancer Sci
; 106(3): 279-86, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25580517
18.
Nicotine induces dendritic spine remodeling in cultured hippocampal neurons.
J Neurochem
; 128(2): 246-55, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24117996
19.
Structure-activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1).
Sci Rep
; 14(1): 4651, 2024 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38409393
20.
Inhibition of cancer-type amino acid transporter LAT1 suppresses B16-F10 melanoma metastasis in mouse models.
Sci Rep
; 13(1): 13943, 2023 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37626086