Assuntos
Cálcio/metabolismo , Líquidos Corporais/análise , Cálcio/análise , Cálcio/sangue , Isótopos de Cálcio , HumanosAssuntos
Proteção Radiológica/normas , Feminino , Feto/efeitos da radiação , Humanos , Gravidez , Doses de RadiaçãoAssuntos
Hepatopatias/diagnóstico , Cintilografia , Doença Aguda , Humanos , Necrose/diagnóstico , Selênio , TecnécioAssuntos
Hepatopatias/diagnóstico , Cintilografia , Doença Aguda , Adolescente , Adulto , Idoso , Aspartato Aminotransferases/sangue , Bilirrubina/sangue , Doença Hepática Induzida por Substâncias e Drogas/complicações , Criança , Feminino , Encefalopatia Hepática/diagnóstico , Hepatite/diagnóstico , Hepatite A/complicações , Humanos , Células de Kupffer , Fígado/patologia , Hepatopatias/etiologia , Hepatopatias/mortalidade , Testes de Função Hepática , Masculino , Pessoa de Meia-Idade , Prognóstico , Tempo de Protrombina , TecnécioRESUMO
Peak activity over the spleen as a percentage of peak activity over the liver was measured in 265 (99m)Technetium sulphur colloid liver scintiscans. The value exceeded 70% in 50 cases. In 32 of these cirrhosis was present; the other 18 scans were from patients with a wide variety of conditions, including secondary deposits, hepatitis, and diseases involving the reticuloendothelial system. A measure of the total activity in the spleen was derived from the peak activity and the length of the spleen. In cirrhosis this was closely related to the finding of oesophageal varices thus showing the importance of a collateral circulation (which allows colloid to bypass the liver) in the increased uptake of colloid by the spleen. In eight patients with hepatosplenomegaly due to blood dyscrasia or disease involving the reticuloendothelial system, total activities in the liver and spleen were estimated from the anteroposterior colour dot scan, and both liver and spleen blood flow were measured by methods independent of reticuloendothelial cell function. The results showed that the main factor causing increased uptake of colloid by the spleen in these diseases was an increased blood flow in the spleen relative to that in the liver.
Assuntos
Hepatopatias/diagnóstico , Cintilografia , Baço/metabolismo , Circulação Colateral , Coloides , Varizes Esofágicas e Gástricas/complicações , Doenças Hematológicas/complicações , Hepatite/diagnóstico , Hepatomegalia/etiologia , Humanos , Circulação Hepática , Cirrose Hepática/complicações , Cirrose Hepática/diagnóstico , Fluxo Sanguíneo Regional , Baço/irrigação sanguínea , Esplenomegalia/etiologia , Tecnécio/metabolismoRESUMO
Forty-eight patients with ;cold areas' on (99m)Tc sulphur colloid liver scintiscans were scanned again using (75)Se-selenomethionine. In 11 patients with primary hepatocellular carcinoma considerable uptake of (75)Se-selenomethionine could be demonstrated in the area of the tumour and uptake of (75)Se-selenomethionine was also observed over extrahepatic metastases in two of these cases. In contrast uptake was low in cholangiocellular carcinoma, Kupffer cell sarcoma, and secondary hepatic deposits (excepting melanoma metastases). No cause for the ;cold area' on the (99m)Tc scan could be discovered in 16 of 25 patients with cirrhosis and in these patients the uptake of the two isotopes in the area of the ;false positive' filling defect was almost equal. Positive identification of primary hepatocellular tumours using this dual scanning technique can be of value in determining and assessing treatment by surgery or cytotoxic therapy.