Detalhe da pesquisa
1.
Inhibitor-Mediated Structural Transition in a Minimal Amyloid Model.
Angew Chem Int Ed Engl
; 61(3): e202113845, 2022 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34791758
2.
Naphthoquinone-Dopamine Hybrids Inhibit α-Synuclein Aggregation, Disrupt Preformed Fibrils, and Attenuate Aggregate-Induced Toxicity.
Chemistry
; 26(69): 16486-16496, 2020 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32870550
3.
Rational Design of a Cocktail of Inhibitors against Aß Aggregation.
Chemistry
; 26(16): 3499-3503, 2020 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32011042
4.
Inhibitory Effect of Naphthoquinone-Tryptophan Hybrid towards Aggregation of PAP f39 Semen Amyloid.
Molecules
; 23(12)2018 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30544943
5.
The contribution of individual residues of an aggregative hexapeptide derived from the human γD-crystallin to its amyloidogenicity.
Int J Biol Macromol
; 201: 182-192, 2022 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34998884
6.
Glucosylceramide Associated with Gaucher Disease Forms Amyloid-like Twisted Ribbon Fibrils That Induce α-Synuclein Aggregation.
ACS Nano
; 15(7): 11854-11868, 2021 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34213307
7.
Site-specific single point mutation by anthranilic acid in hIAPP8-37 enhances anti-amyloidogenic activity.
RSC Chem Biol
; 2(1): 266-273, 2021 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34458787
8.
Dual concentration-dependent effect of ascorbic acid on PAP(248-286) amyloid formation and SEVI-mediated HIV infection.
RSC Chem Biol
; 2(5): 1534-1545, 2021 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34704058
9.
Inhibition of tau amyloid formation and disruption of its preformed fibrils by Naphthoquinone-Dopamine hybrid.
FEBS J
; 288(14): 4267-4290, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33523571
10.
Peptidomimetics prepared by tail-to-side chain one component peptide stapling inhibit Alzheimer's amyloid-ß fibrillogenesis.
Chem Sci
; 11(16): 4171-4179, 2020 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34122880
11.
An amyloidogenic hexapeptide from the cataract-associated γD-crystallin is a model for the full-length protein and is inhibited by naphthoquinone-tryptophan hybrids.
Int J Biol Macromol
; 157: 424-433, 2020 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32302630
12.
An explicitly designed paratope of amyloid-ß prevents neuronal apoptosis in vitro and hippocampal damage in rat brain.
Chem Sci
; 12(8): 2853-2862, 2020 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34164050
13.
Tryptophan-galactosylamine conjugates inhibit and disaggregate amyloid fibrils of Aß42 and hIAPP peptides while reducing their toxicity.
Commun Biol
; 3(1): 484, 2020 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32879439
14.
Naphthoquinone Tryptophan Hybrids: A Promising Small Molecule Scaffold for Mitigating Aggregation of Amyloidogenic Proteins and Peptides.
Front Cell Dev Biol
; 7: 242, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31750300
15.
Novel Mannitol-Based Small Molecules for Inhibiting Aggregation of α-Synuclein Amyloids in Parkinson's Disease.
Front Mol Biosci
; 6: 16, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30968030
16.
Novel model of secreted human tau protein reveals the impact of the abnormal N-glycosylation of tau on its aggregation propensity.
Sci Rep
; 9(1): 2254, 2019 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30783169
17.
Antagonistic Activity of Naphthoquinone-Based Hybrids toward Amyloids Associated with Alzheimer's Disease and Type-2 Diabetes.
ACS Chem Neurosci
; 10(8): 3510-3520, 2019 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31282646
18.
Tryptophan-glucosamine conjugates modulate tau-derived PHF6 aggregation at low concentrations.
Chem Commun (Camb)
; 55(97): 14621-14624, 2019 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31746849
19.
Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids.
Sci Rep
; 8(1): 71, 2018 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29311706
20.
Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules: mechanistic insights and design rules.
Future Med Chem
; 9(8): 797-810, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28485623