Detalhe da pesquisa
1.
ß-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.
Cell
; 181(6): 1364-1379.e14, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32470395
2.
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Cell
; 161(6): 1252-65, 2015 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26046436
3.
Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.
Biochemistry
; 62(7): 1233-1248, 2023 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36917754
4.
An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase.
Antimicrob Agents Chemother
; 66(4): e0210921, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35266827
5.
The Compound SBI-0090799 Inhibits Zika Virus Infection by Blocking De Novo Formation of the Membranous Replication Compartment.
J Virol
; 95(22): e0099621, 2021 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34468177
6.
Targeting eIF4F translation initiation complex with SBI-756 sensitises B lymphoma cells to venetoclax.
Br J Cancer
; 124(6): 1098-1109, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33318657
7.
Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition.
Bioorg Med Chem Lett
; 43: 128048, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33887438
8.
Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators.
Bioorg Med Chem Lett
; 41: 128007, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33798699
9.
Inhibition of tissue-nonspecific alkaline phosphatase protects against medial arterial calcification and improves survival probability in the CKD-MBD mouse model.
J Pathol
; 250(1): 30-41, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31509234
10.
Discovery of DS68702229 as a Potent, Orally Available NAMPT (Nicotinamide Phosphoribosyltransferase) Activator.
Chem Pharm Bull (Tokyo)
; 69(11): 1110-1122, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34719594
11.
Loss of tissue-nonspecific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis.
Brain Behav Immun
; 84: 115-131, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31778743
12.
Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma.
Bioorg Med Chem Lett
; 30(4): 126899, 2020 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31882297
13.
Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.
Nat Chem Biol
; 13(5): 486-493, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28244987
14.
Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat Chem Biol
; 13(6): 624-632, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28346406
15.
Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies.
Malar J
; 18(1): 22, 2019 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30683097
16.
TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling.
Hepatology
; 66(4): 1197-1218, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28543567
17.
Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.
Bioorg Med Chem Lett
; 28(1): 31-34, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29174347
18.
Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5'-exonuclease activity.
J Biol Chem
; 289(11): 7825-34, 2014 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24500713
19.
Imidazole-derived agonists for the neurotensin 1 receptor.
Bioorg Med Chem Lett
; 24(1): 262-7, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24332089
20.
Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.
Bioorg Med Chem Lett
; 24(3): 1000-1004, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24412070