[Biotoxicological research on a segment of the population in an industrial environment. I. Total proteins, hemoglobin, methemoglobin and cholinesterase]. / Cercetarea biotoxicologica la un segment de populatie din mediul industrial. Nota I. Proteine totale, hemoglobina, methemoglobina si colinesteraza.

The inevitable chemical risks present in a synthetic threads and fibres aggregate works determine a careful and permanent surveillance of employees' state of health, especially where the occupational risk is known to exist. Besides the usual labour protection measures, screening for the early detection of some biochemical or biotoxicological changes induced by the contact with the chemical noxae in the labour environment are performed. This paper presents the results of a complex biochemical and biotoxicological screening including about 300 employees working at the polyplants in the melanin section where the major chemical noxa is acrylonitrile. The total proteins, hemoglobin, methemoglobin and cholinesterase activity were determined.

[Peroxide radicals in the metabolism of toxic substances]. / Radicalii peroxidici în metabolizarea substantelor toxice.

The free radicals resulting from the metabolism of oxygen and some xenobiotics, can induce, when a limit concentration is exceeded, toxic effects due to their action on DNA, enzymes and fatty acids. Therefore, the association of oxygen therapy with drug administration may have a more or less beneficial effect. Thus, in a long-term treatment with drugs which by metabolized release free radicals, the use of exogenous compounds for protecting the human body need to be administered.

[Biotoxicological research on a segment of the population in an industrial environment. II. Gamma-glutamyltranspeptidase, alkaline phosphatase and urinary thiocyanates]. / Cercetarea biotoxicologica la un segment de populatie din mediul industrial. Nota II. Gama-glutamiltranspeptidaza, fosfataza alcalina, tiocianatii urinari.

The results of a populational study on detecting some early changes in the activity of gamma-glutamyltranspeptidase and alkaline phosphatase under the influence of industrial noxae in synthetic fibers plants are presented. At the same time thiocyanaturia, as an indicator of cian ion detoxication as well as of the noxious effect of smoking, was determined. The individual results showed only significant alterations in the activity of gamma-glutamyltranspeptidase, reason for which the respective individuals were referred to specialized medical institutions for complex laboratory and clinical investigations. On this occasion some alcohol addicts were also detected. The increased thiocyanaturia levels are explained only by tobacco smoking, as the professional noxae were always under the admitted limit.

[Studies regarding the fixing of the zinc from ADH through some azopyrazolone]. / Cercetari privind modul de fixare a zincului din ADH prin intermediul unor azopirazolone.

The mechanism of reaction-between the zinc atom of alcohol dehydrogenase and 6 pyrazolone and azopyrazolone compounds, type 1-(4'-carboxyphenyl)-3-methyl-4(1"azo-4"-ethoxy-phenyl)-5-pyrazolone, synthetized by the authors, is studied. For elucidating the "in vivo" phenomenon, the complexes of these compounds were synthetized with zinc atoms, the IR specters and quantitative chemical analyses being followed. Based on these, the possibilities of complexing the zinc from the ADH molecule by these compounds are discussed.

[The effect of chemical noxae on the health status of a group of workers in the chemical industry of Savinesti]. / Influenta unor noxe chimice asupra starii de sanatate, la un grup de muncitori din industria chimica, Savinesti.

The paper presents the study on the effect of the industrial xenobiotics against some biochemical indicators, in view to detect, precociously, the probable significant changes. There are presented the medium, minimum, maximum and median value for the following parameters: total proteins, haemoglobin and glucose for 112 workers exposed or not exposed to specific noxae--benzen, phenol, cyclohexanone. The analysis of the results shows decreased values for some workers, even at the inferior limit, in rapport with the normal values, for the parameters studied. These persons have been directed for complex investigations, in view to determine the causes and to establish the adequate treatment.