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1.

Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development.

Mastellos, Dimitrios C; Blom, Anna M; Connolly, E Sander; Daha, Mohamed R; Geisbrecht, Brian V; Ghebrehiwet, Berhane; Gros, Piet; Hajishengallis, George; Holers, V Michael; Huber-Lang, Markus; Kinoshita, Taroh; Mollnes, Tom E; Montgomery, Robert A; Morgan, B Paul; Nilsson, Bo; Pio, Ruben; Ricklin, Daniel; Risitano, Antonio M; Taylor, Ronald P; Mantovani, Alberto; Ioannidis, John P A; Lambris, John D.

Nat Immunol ; 20(11): 1556, 2019 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-31605100

2.

The complement alternative pathway in paroxysmal nocturnal hemoglobinuria: From a pathogenic mechanism to a therapeutic target.

Risitano, Antonio M; Frieri, Camilla; Urciuoli, Eleonora; Marano, Luana.

Immunol Rev ; 313(1): 262-278, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36110036

3.

'Stealth' corporate innovation: an emerging threat for therapeutic drug development.

Mastellos, Dimitrios C; Blom, Anna M; Connolly, E Sander; Daha, Mohamed R; Geisbrecht, Brian V; Ghebrehiwet, Berhane; Gros, Piet; Hajishengallis, George; Holers, V Michael; Huber-Lang, Markus; Kinoshita, Taroh; Mollnes, Tom E; Montgomery, Robert A; Morgan, B Paul; Nilsson, Bo; Pio, Ruben; Ricklin, Daniel; Risitano, Antonio M; Taylor, Ronald P; Mantovani, Alberto; Ioannidis, John P A; Lambris, John D.

Nat Immunol ; 20(11): 1409-1413, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31562490

4.

Discovering C3 targeting therapies for paroxysmal nocturnal hemoglobinuria: Achievements and pitfalls.

Risitano, Antonio M; Peffault de Latour, Regis; Marano, Luana; Frieri, Camilla.

Semin Immunol ; 59: 101618, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-35764467

5.

Eltrombopag Added to Immunosuppression in Severe Aplastic Anemia.

Peffault de Latour, Régis; Kulasekararaj, Austin; Iacobelli, Simona; Terwel, Sofie R; Cook, Riley; Griffin, Morag; Halkes, Constantijn J M; Recher, Christian; Barraco, Fiorenza; Forcade, Edouard; Vallejo, Juan-Carlos; Drexler, Beatrice; Mear, Jean-Baptiste; Smith, Alexander E; Angelucci, Emanuele; Raymakers, Reinier A P; de Groot, Marco R; Daguindau, Etienne; Nur, Erfan; Barcellini, Wilma; Russell, Nigel H; Terriou, Louis; Iori, Anna-Paola; La Rocca, Ursula; Sureda, Anna; Sánchez-Ortega, Isabel; Xicoy, Blanca; Jarque, Isidro; Cavenagh, James; Sicre de Fontbrune, Flore; Marotta, Serena; Munir, Talha; Tjon, Jennifer M L; Tavitian, Suzanne; Praire, Aline; Clement, Laurence; Rabian, Florence; Marano, Luana; Hill, Anita; Palmisani, Elena; Muus, Petra; Cacace, Fabiana; Frieri, Camilla; van Lint, Maria-Teresa; Passweg, Jakob R; Marsh, Judith C W; Socié, Gérard; Mufti, Ghulam J; Dufour, Carlo; Risitano, Antonio M.

N Engl J Med ; 386(1): 11-23, 2022 01 06.

Artigo em Inglês | MEDLINE | ID: mdl-34986284

6.

Phase 2 study of danicopan in patients with paroxysmal nocturnal hemoglobinuria with an inadequate response to eculizumab.

Kulasekararaj, Austin G; Risitano, Antonio M; Maciejewski, Jaroslaw P; Notaro, Rosario; Browett, Peter; Lee, Jong Wook; Huang, Mingjun; Geffner, Michael; Brodsky, Robert A.

Blood ; 138(20): 1928-1938, 2021 11 18.

Artigo em Inglês | MEDLINE | ID: mdl-34314483

7.

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.

Schubart, Anna; Anderson, Karen; Mainolfi, Nello; Sellner, Holger; Ehara, Takeru; Adams, Christopher M; Mac Sweeney, Aengus; Liao, Sha-Mei; Crowley, Maura; Littlewood-Evans, Amanda; Sarret, Sophie; Wieczorek, Grazyna; Perrot, Ludovic; Dubost, Valérie; Flandre, Thierry; Zhang, Yuzhou; Smith, Richard J H; Risitano, Antonio M; Karki, Rajeshri G; Zhang, Chun; Valeur, Eric; Sirockin, Finton; Gerhartz, Bernd; Erbel, Paulus; Hughes, Nicola; Smith, Thomas M; Cumin, Frederic; Argikar, Upendra A; Haraldsson, Börje; Mogi, Muneto; Sedrani, Richard; Wiesmann, Christian; Jaffee, Bruce; Maibaum, Jürgen; Flohr, Stefanie; Harrison, Richard; Eder, Jörg.

Proc Natl Acad Sci U S A ; 116(16): 7926-7931, 2019 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-30926668

8.

Danicopan: an oral complement factor D inhibitor for paroxysmal nocturnal hemoglobinuria

Risitano, Antonio M; Kulasekararaj, Austin G; Lee, Jong Wook; Maciejewski, Jaroslaw P; Notaro, Rosario; Brodsky, Robert; Huang, Mingjun; Geffner, Michael; Browett, Peter.

Haematologica ; 106(12): 3188-3197, 2021 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-33121236

9.

Characterization of breakthrough hemolysis events observed in the phase 3 randomized studies of ravulizumab versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria.

Brodsky, Robert A; Peffault de Latour, Régis; Rottinghaus, Scott T; Röth, Alexander; Risitano, Antonio M; Weitz, Ilene C; Hillmen, Peter; Maciejewski, Jaroslaw P; Szer, Jeff; Lee, Jong Wook; Kulasekararaj, Austin G; Volles, Lori; Damokosh, Andrew I; Ortiz, Stephan; Shafner, Lori; Liu, Peng; Hill, Anita; Schrezenmeier, Hubert.

Haematologica ; 106(1): 230-237, 2021 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-31949012

10.

The role of ponatinib in adult BCR-ABL1 positive acute lymphoblastic leukemia after allogeneic transplantation: a real-life retrospective multicenter study.

Leotta, Salvatore; Markovic, Uros; Pirosa, Maria Cristina; Stella, Stefania; Tringali, Stefania; Martino, Massimo; Specchia, Giorgina; Carluccio, Paola; Risitano, Antonio M; Grimaldi, Francesco; Vigna, Ernesto; Palmieri, Fausto; Palmieri, Raffaele; Annunziata, Mario; Pisapia, Giovanni; Palazzo, Giulia; Milone, Giulio Antonio; Pelle, Angelo Curto; Scalise, Luca; Di Giorgio, Mary Ann; Bulla, Anna; Leotta, Valerio; Di Raimondo, Francesco; Milone, Giuseppe.

Ann Hematol ; 100(7): 1743-1753, 2021 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-33774681

11.

The first case of COVID-19 treated with the complement C3 inhibitor AMY-101.

Mastaglio, Sara; Ruggeri, Annalisa; Risitano, Antonio M; Angelillo, Piera; Yancopoulou, Despina; Mastellos, Dimitrios C; Huber-Lang, Markus; Piemontese, Simona; Assanelli, Andrea; Garlanda, Cecilia; Lambris, John D; Ciceri, Fabio.

Clin Immunol ; 215: 108450, 2020 06.

Artigo em Inglês | MEDLINE | ID: mdl-32360516

12.

Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy.

Mastellos, Dimitrios C; Pires da Silva, Bruno G P; Fonseca, Benedito A L; Fonseca, Natasha P; Auxiliadora-Martins, Maria; Mastaglio, Sara; Ruggeri, Annalisa; Sironi, Marina; Radermacher, Peter; Chrysanthopoulou, Akrivi; Skendros, Panagiotis; Ritis, Konstantinos; Manfra, Ilenia; Iacobelli, Simona; Huber-Lang, Markus; Nilsson, Bo; Yancopoulou, Despina; Connolly, E Sander; Garlanda, Cecilia; Ciceri, Fabio; Risitano, Antonio M; Calado, Rodrigo T; Lambris, John D.

Clin Immunol ; 220: 108598, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32961333

13.

Pharmacokinetic and pharmacodynamic effects of ravulizumab and eculizumab on complement component 5 in adults with paroxysmal nocturnal haemoglobinuria: results of two phase 3 randomised, multicentre studies.

Peffault de Latour, Régis; Brodsky, Robert A; Ortiz, Stephan; Risitano, Antonio M; Jang, Jun H; Hillmen, Peter; Kulagin, Alexander D; Kulasekararaj, Austin G; Rottinghaus, Scott T; Aguzzi, Rasha; Gao, Xiang; Wells, Richard A; Szer, Jeff.

Br J Haematol ; 191(3): 476-485, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32449174

14.

PNH and complement gene variants.

Risitano, Antonio M.

Blood ; 141(15): 1780-1782, 2023 04 13.

Artigo em Inglês | MEDLINE | ID: mdl-37052944

15.

Therapeutic complement inhibition in complement-mediated hemolytic anemias: Past, present and future.

Risitano, Antonio M; Marotta, Serena.

Semin Immunol ; 28(3): 223-40, 2016 06.

Artigo em Inglês | MEDLINE | ID: mdl-27346521

16.

The Case for Upfront HLA-Matched Unrelated Donor Hematopoietic Stem Cell Transplantation as a Curative Option for Adult Acquired Severe Aplastic Anemia.

Marsh, Judith C W; Risitano, Antonio M; Mufti, Ghulam J.

Biol Blood Marrow Transplant ; 25(9): e277-e284, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31129354

17.

Mutant UBA1 and Severe Adult-Onset Autoinflammatory Disease.

Luzzatto, Lucio; Risitano, Antonio M; Notaro, Rosario.

N Engl J Med ; 384(22): 2164, 2021 Jun 03.

Artigo em Inglês | MEDLINE | ID: mdl-34077653

18.

Pegcetacoplan versus Eculizumab in PNH. Reply.

Hillmen, Peter; Risitano, Antonio M; Peffault de Latour, Régis.

N Engl J Med ; 385(18): 1725-1726, 2021 10 28.

Artigo em Inglês | MEDLINE | ID: mdl-34706185

19.

Understanding pharmacological complement inhibition in paroxysmal nocturnal hemoglobinuria.

Risitano, Antonio M; Frieri, Camilla.

Haematologica ; 109(3): 704-708, 2024 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-37675510

20.

Factor H interferes with the adhesion of sickle red cells to vascular endothelium: a novel disease-modulating molecule.

Lombardi, Elisabetta; Matte, Alessandro; Risitano, Antonio M; Ricklin, Daniel; Lambris, John D; De Zanet, Denise; Jokiranta, Sakari T; Martinelli, Nicola; Scambi, Cinzia; Salvagno, Gianluca; Bisoffi, Zeno; Colato, Chiara; Siciliano, Angela; Bortolami, Oscar; Mazzuccato, Mario; Zorzi, Francesco; De Marco, Luigi; De Franceschi, Lucia.

Haematologica ; 104(5): 919-928, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30630982

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