RESUMO
PURPOSE: The assessment of low-contrast-details is a part of the quality control (QC) program in digital radiology. It generally consists of evaluating the threshold contrast (Cth) detectability details for different-sized inserts, appropriately located in dedicated QC test tools. This work aims to propose a simplified method, based on a statistical model approach for threshold contrast estimation, suitable for different modalities in digital radiology. METHODS: A home-madelow-contrast phantom, made of a central aluminium insert with a step-wedge, was assembled and tested. The reliability and robustness of the method were investigated for Mammography, Digital Radiography, Fluoroscopy and Angiography. Imageswere analysed using our dedicated software developed on Matlab®. TheCth is expressed in the same unit (mmAl) for all studied modalities. RESULTS: This method allows the collection of Cthinformation from different modalities and equipment by different vendors, and it could be used to define typical values. Results are summarized in detail. For 0.5 diameter detail, Cthresults are in the range of: 0.018-0.023 mmAl for 2D mammography and 0.26-0.34 mmAl DR images. For angiographic images, for 2.5 mm diameter detail, the Cths median values are 0.55, 0.4, 0.06, 0.12 mmAl for low dose fluoroscopy, coronary fluorography, cerebral and abdominal DSA, respectively. CONCLUSIONS: The statistical method proposed in this study gives a simple approach for Low-Contrast-Details assessment, and the typical values proposed can be implemented in a QA program for digital radiology modalities.
Assuntos
Mamografia , Intensificação de Imagem Radiográfica , Imagens de Fantasmas , Controle de Qualidade , Reprodutibilidade dos TestesRESUMO
PURPOSE: Validate the skin dose software within the radiation dose index monitoring system NEXO[DOSE]® (Bracco Injeneering S.A., Lausanne, Switzerland). It provides the skin dose distribution in interventional radiology (IR) procedures. METHODS: To determine the skin dose distribution and the Peak Skin Dose (PSD) in IR procedures, the software uses exposure and geometrical parameters taken from the radiation dose structured report and additional information specific to each angiographic system. To test the accuracy of the software, GafChromic® XR-RV3 films, wrapped under a cylindrical PMMA phantom, were irradiated with different setups. Calculations and films results are compared in terms of absolute dose and geometric accuracy, using two angiographic systems (Philips Integris Allura FD20, Siemens AXIOM-ArtisZeego). RESULTS: Calculated and film measured PSD values agree with an average difference of 7% ± 5%. The discrepancies in dose evaluation increase up to 33% in lower dose regions, because the algorithm does not consider the out-of-field scatter contribution of the neighboring fields, which is more significant in these areas. Regarding the geometric accuracy, the differences between the simulated dose spatial distributions and the measured ones are<3 mm (4%) in simple tests and 5 mm (5%) in setups closer to clinical practice. Moreover, similar results are obtained for the two studied angiographic system vendors. CONCLUSIONS: NEXO[DOSE]® provides an accurate skin dose distribution and PSD estimate. It will allow faster and more accurate monitoring of patient follow-up in the future.
Assuntos
Doses de Radiação , Radiologia Intervencionista/métodos , Pele/efeitos da radiação , Software , Angiografia , Dosimetria Fotográfica , Humanos , Imagens de Fantasmas , Pele/diagnóstico por imagemRESUMO
BACKGROUND: Radiation dose in computed tomography (CT) has become a topic of high interest due to the increasing numbers of CT examinations performed worldwide. Hence, dose tracking and organ dose calculation software are increasingly used. We evaluated the organ dose variability associated with the use of different software applications or calculation methods. METHODS: We tested four commercial software applications on CT protocols actually in use in our hospital: CT-Expo, NCICT, NCICTX, and Virtual Dose. We compared dose coefficients, estimated organ doses and effective doses obtained by the four software applications by varying exposure parameters. Our results were also compared with estimates reported by the software authors. RESULTS: All four software applications showed dependence on tube voltage and volume CT dose index, while only CT-Expo was also dependent on other exposure parameters, in particular scanner model and pitch caused a variability till 50%. We found a disagreement between our results and those reported by the software authors (up to 600%), mainly due to a different extent of examined body regions. The relative range of the comparison of the four software applications was within 35% for most organs inside the scan region, but increased over the 100% for organs partially irradiated and outside the scan region. For effective doses, this variability was less evident (ranging from 9 to 36%). CONCLUSIONS: The two main sources of organ dose variability were the software application used and the scan region set. Dose estimate must be related to the process used for its calculation.
Assuntos
Doses de Radiação , Software , Tomografia Computadorizada por Raios X , Pontos de Referência Anatômicos , Humanos , Imagens de FantasmasRESUMO
CONTEXT: Polymyxin B fiber column is a medical device designed to reduce blood endotoxin levels in sepsis. Gram-negative-induced abdominal sepsis is likely associated with high circulating endotoxin. Reducing circulating endotoxin levels with polymyxin B hemoperfusion could potentially improve patient clinical outcomes. OBJECTIVE: To determine whether polymyxin B hemoperfusion added to conventional medical therapy improves clinical outcomes (mean arterial pressure [MAP], vasopressor requirement, oxygenation, organ dysfunction) and mortality compared with conventional therapy alone. DESIGN, SETTING, AND PATIENTS: A prospective, multicenter, randomized controlled trial (Early Use of Polymyxin B Hemoperfusion in Abdominal Sepsis [EUPHAS]) conducted at 10 Italian tertiary care intensive care units between December 2004 and December 2007. Sixty-four patients were enrolled with severe sepsis or septic shock who underwent emergency surgery for intra-abdominal infection. INTERVENTION: Patients were randomized to either conventional therapy (n=30) or conventional therapy plus 2 sessions of polymyxin B hemoperfusion (n=34). MAIN OUTCOME MEASURES: Primary outcome was change in MAP and vasopressor requirement, and secondary outcomes were PaO(2)/FIO(2) (fraction of inspired oxygen) ratio, change in organ dysfunction measured using Sequential Organ Failure Assessment (SOFA) scores, and 28-day mortality. RESULTS: MAP increased (76 to 84 mm Hg; P = .001) and vasopressor requirement decreased (inotropic score, 29.9 to 6.8; P < .001) at 72 hours in the polymyxin B group but not in the conventional therapy group (MAP, 74 to 77 mm Hg; P = .37; inotropic score, 28.6 to 22.4; P = .14). The PaO(2)/FIO(2) ratio increased slightly (235 to 264; P = .049) in the polymyxin B group but not in the conventional therapy group (217 to 228; P = .79). SOFA scores improved in the polymyxin B group but not in the conventional therapy group (change in SOFA, -3.4 vs -0.1; P < .001), and 28-day mortality was 32% (11/34 patients) in the polymyxin B group and 53% (16/30 patients) in the conventional therapy group (unadjusted hazard ratio [HR], 0.43; 95% confidence interval [CI], 0.20-0.94; adjusted HR, 0.36; 95% CI, 0.16-0.80). CONCLUSION: In this preliminary study, polymyxin B hemoperfusion added to conventional therapy significantly improved hemodynamics and organ dysfunction and reduced 28-day mortality in a targeted population with severe sepsis and/or septic shock from intra-abdominal gram-negative infections. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00629382.
Assuntos
Abdome , Antibacterianos , Doenças do Sistema Digestório/terapia , Infecções por Bactérias Gram-Negativas/terapia , Hemoperfusão/instrumentação , Polimixina B , Choque Séptico/terapia , Antibacterianos/uso terapêutico , Doenças do Sistema Digestório/mortalidade , Infecções por Bactérias Gram-Negativas/mortalidade , Hemodinâmica , Humanos , Polimixina B/uso terapêutico , Estudos Prospectivos , Transporte Respiratório , Choque Séptico/mortalidade , Choque Séptico/fisiopatologiaRESUMO
BACKGROUND: To manage and analyse dosimetric data provided by computed tomography (CT) scanners from four Italian hospitals. METHODS: A radiation dose index monitoring (RDIM) software was used to collect anonymised exams stored in a cloud server. Since hospitals use different names for the same procedure, digital imaging and communications in medicine (DICOM) tags more appropriate to describe exams were selected and associated to study common names (SCNs) from a radiology playbook according to scan region and use of contrast media. Retrospective analysis was carried out to describe population and to evaluate dosimetric indexes and inaccuracies associated with SCNs. RESULTS: More than 400 procedures were clustered into 95 SCNs, but 78% of exams on adults were described with only 10 SCNs. Median values of dose-length product (DLP) and volumetric CT dose index (CTDIvol) for three analysed SCNs were in agreement with those previously published. The percentage of inaccuracies does not heavily affect the dosimetric analysis on the whole cloud, since variations in median values reached at most 8%. CONCLUSIONS: Implementation of a cloud-based RDIM software and related issues were described, showing the strength of the chosen playbook-based clustering and its usefulness for homogeneous data analysis. This approach may allow for optimisation actions, accurate assessment of the risk associated with radiation exposure, comparison of different facilities, and, last but not least, collection of information for the implementation of the 2013/59 Euratom Directive.