Detalhe da pesquisa
1.
Cyanide Trapping of Iminium Ion Reactive Metabolites: Implications for Clinical Hepatotoxicity.
Chem Res Toxicol
; 37(5): 698-710, 2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38619497
2.
Evaluation of a Three-Dimensional Primary Human Hepatocyte Spheroid Model: Adoption and Industrialization for the Enhanced Detection of Drug-Induced Liver Injury.
Chem Res Toxicol
; 34(12): 2485-2499, 2021 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34797640
3.
A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment.
Toxicol Sci
; 197(1): 38-52, 2023 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37788119
4.
Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development.
Adv Biol (Weinh)
; : e2300131, 2023 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37814378
5.
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Chem Res Toxicol
; 25(10): 2067-82, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22931300
6.
Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds.
Toxicol Sci
; 175(2): 266-278, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32159798
7.
The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.
Bioorg Med Chem Lett
; 18(11): 3386-91, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18455394
8.
An integrated reactive metabolite evaluation approach to assess and reduce safety risk during drug discovery and development.
Chem Biol Interact
; 192(1-2): 60-4, 2011 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-20970409
9.
A quantitative high-throughput trapping assay as a measurement of potential for bioactivation.
Anal Biochem
; 351(2): 266-72, 2006 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16473319