Detalhe da pesquisa
1.
Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats.
Toxicol Pathol
; 49(6): 1174-1192, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34060347
2.
Genotoxicity Assessment of Drug Metabolites in the Context of MIST and Beyond.
Chem Res Toxicol
; 33(1): 10-19, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31859487
3.
Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges.
Drug Metab Dispos
; 47(12): 1443-1456, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31748266
4.
A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance.
Drug Metab Dispos
; 46(6): 865-878, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-29487142
5.
Identification of GalNAc-Conjugated Antisense Oligonucleotide Metabolites Using an Untargeted and Generic Approach Based on High Resolution Mass Spectrometry.
Anal Chem
; 89(12): 6821-6826, 2017 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28520401
6.
A double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [14C]-basimglurant and absolute bioavailability after oral administration and concomitant intravenous microdose administration of [13C6]-labeled basimglurant in humans.
Xenobiotica
; 47(2): 144-153, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27123695
7.
In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA.
Anal Chem
; 88(23): 11670-11677, 2016 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27934109
8.
Shedding light on minipig drug metabolism - elevated amide hydrolysis in vitro.
Xenobiotica
; 46(6): 483-94, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26405846
9.
A New Rapid In Vitro Assay for Assessing Reactivity of Acyl Glucuronides.
Drug Metab Dispos
; 43(11): 1711-7, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26276581
10.
The Importance of Tracking "Missing" Metabolites: How and Why?
J Med Chem
; 66(23): 15586-15612, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37769129
11.
Investigation of figopitant and its metabolites in rat tissue by combining whole-body autoradiography with liquid extraction surface analysis mass spectrometry.
Drug Metab Dispos
; 40(3): 419-25, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22184457
12.
Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers.
Mol Ther Nucleic Acids
; 29: 176-188, 2022 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35860384
13.
Absolute Bioavailability of Vemurafenib in Patients With BRAFV600 Mutation-Positive Malignancies.
Clin Pharmacol Drug Dev
; 9(4): 496-504, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32083398
14.
Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator.
Toxicol Sci
; 176(2): 329-342, 2020 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32458970
15.
2-Amino-2-deoxyisochorismate is a key intermediate in Bacillus subtilis p-aminobenzoic acid biosynthesis.
J Am Chem Soc
; 131(10): 3481-3, 2009 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19275258
16.
Studying the Biotransformation of Phosphorothioate-Containing Oligonucleotide Drugs by LC-MS.
Methods Mol Biol
; 2036: 307-315, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31410805
17.
Advanced MALDI mass spectrometry imaging in pharmaceutical research and drug development.
Curr Opin Biotechnol
; 55: 51-59, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30153614
18.
The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1.
Sci Rep
; 9(1): 4074, 2019 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30858459
19.
Profiling of dalcetrapib metabolites in human plasma by accelerator mass spectrometry and investigation of the free phenothiol by derivatisation with methylacrylate.
J Pharm Biomed Anal
; 152: 143-154, 2018 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29414006
20.
Application of Imaging Techniques to Cases of Drug-Induced Crystal Nephropathy in Preclinical Studies.
Toxicol Sci
; 163(2): 409-419, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28329870