Detalhe da pesquisa
1.
Recommendations on the Use of Multiple Labels in Human Mass Balance Studies.
Drug Metab Dispos
; 52(3): 153-158, 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38216306
2.
Human Absorption, Distribution, Metabolism, and Excretion Studies: Origins, Innovations, and Importance.
Drug Metab Dispos
; 51(6): 647-656, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36973000
3.
A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance.
Drug Metab Dispos
; 46(6): 865-878, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-29487142
4.
Quantitative projection of human brain penetration of the H3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy.
Xenobiotica
; 47(2): 119-126, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27353353
5.
Biosynthesis of drug metabolites and quantitation using NMR spectroscopy for use in pharmacologic and drug metabolism studies.
Drug Metab Dispos
; 42(10): 1627-39, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25053618
6.
Metabolite Bioanalysis in Drug Development: Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group.
Clin Pharmacol Ther
; 115(5): 939-953, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38073140
7.
Non-Labeled, Stable Labeled, or Radiolabelled Approaches for Provision of Intravenous Pharmacokinetics in Humans: A Discussion Piece.
Clin Pharmacol Ther
; 115(5): 931-938, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38018358
8.
Considerations for Human ADME Strategy and Design Paradigm Shift(s) - An Industry White Paper.
Clin Pharmacol Ther
; 113(4): 775-781, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35733280
9.
Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs.
Drug Metab Dispos
; 40(3): 625-34, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22190693
10.
Mini-Review: Comprehensive Drug Disposition Knowledge Generated in the Modern Human Radiolabeled ADME Study.
CPT Pharmacometrics Syst Pharmacol
; 9(8): 428-434, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32562380
11.
Effective Application of Metabolite Profiling in Drug Design and Discovery.
J Med Chem
; 63(12): 6387-6406, 2020 06 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32097005
12.
Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure-Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H1 Receptor Inverse Agonist.
J Med Chem
; 63(13): 7268-7292, 2020 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32462865
13.
Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists.
Bioorg Med Chem Lett
; 19(16): 4747-51, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19576766
14.
3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization.
Bioorg Med Chem Lett
; 19(9): 2524-9, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19328692
15.
The role of muscarinic receptor antagonism in antipsychotic-induced hippocampal acetylcholine release.
Eur J Pharmacol
; 506(3): 209-19, 2005 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-15627430
16.
Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764).
J Med Chem
; 54(21): 7602-20, 2011 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21928839
17.
Differential effects of various typical and atypical antipsychotics on plasma glucose and insulin levels in the mouse: evidence for the involvement of sympathetic regulation.
Schizophr Bull
; 36(2): 410-8, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18703666
18.
Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.
J Med Chem
; 53(3): 1222-37, 2010 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20043678
19.
Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.
J Pharmacol Exp Ther
; 319(2): 924-33, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16920992
20.
The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model.
Drug Metab Dispos
; 33(1): 165-74, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15502009