Detalhe da pesquisa
1.
Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells.
Nucleic Acids Res
; 43(2): 1204-15, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25550434
2.
PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene.
Blood
; 124(11): 1777-89, 2014 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25006129
3.
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.
Nature
; 463(7280): 501-6, 2010 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20072125
4.
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.
Proc Natl Acad Sci U S A
; 110(50): 20224-9, 2013 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24277854
5.
An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy.
Oncoimmunology
; 10(1): 1881268, 2021 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33796402
6.
Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models.
Sci Transl Med
; 13(610): eabc7804, 2021 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34516826
7.
SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models.
Mol Cancer Ther
; 20(2): 250-262, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33310762
8.
Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma.
ACS Med Chem Lett
; 11(10): 1899-1904, 2020 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33062171
9.
Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation.
Nat Cancer
; 1(1): 86-98, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35121834
10.
Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer.
J Med Chem
; 63(2): 512-528, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31721572
11.
Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.
Cell Chem Biol
; 25(6): 705-717.e11, 2018 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29628435
12.
Oncogenic dependency on ß-catenin in liver cancer cell lines correlates with pathway activation.
Oncotarget
; 8(70): 114526-114539, 2017 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-29383099
13.
Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model.
Cancer Res
; 63(1): 80-5, 2003 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12517781
14.
Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors.
ACS Med Chem Lett
; 7(7): 676-80, 2016 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27437076
15.
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents.
Sci Rep
; 5: 7642, 2015 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25560837
16.
(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.
ACS Med Chem Lett
; 6(5): 562-7, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26005534
17.
Anti-miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation.
Mol Cancer Res
; 13(6): 1009-21, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25758165
18.
Optically imageable metastatic model of human breast cancer.
Clin Exp Metastasis
; 19(4): 347-50, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12090475
19.
Antimetastatic efficacy of oral 5-FU imaged by green fluorescent protein in real time.
Anticancer Res
; 23(1A): 1-6, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12680187
20.
Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.
ACS Med Chem Lett
; 3(2): 140-5, 2012 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900443