Efficacy and safety of 0.5% colchicine cream versus 5% 5-fluorouracil cream in the treatment of cutaneous field cancerization: a randomized clinical trial.

BACKGROUND: 5-Fluorouracil (5-FU) is a first-line drug to treat cutaneous field cancerization (CFC). There are few clinical trials with topical colchicine (COL). OBJECTIVE: To evaluate the effectiveness of 0.5% COL cream versus 5% 5-FU cream in the treatment of CFC. METHOD: This was a randomized, open, self-controlled clinical trial. Forty-five patients (90 forearms), with three to ten actinic keratoses (AK) on each forearm, used 0.5% COL cream 2×/day for seven days on one forearm, and 5% 5-FU cream 2× /day, for 21 days, on the other forearm. The dosages were defined based on previous clinical trials for each drug. Adverse effects were evaluated after 14 days and outcomes after 90 days of inclusion. The primary outcome was complete AK clearance and the secondary outcomes were: partial clearance (≥50%), reduction in AK count, assessment of the Forearm Photoaging Scale (FPS), AK Severity Score (AKSS), and adverse effects. RESULTS: After 90 days, there was complete clearance of AK in 37% (95% CI 24%-49%) and partial clearance in 85% (95% CI 76%-93%) of the forearms treated with 5-FU,versus 17% (95% CI 7%-27%) and 78% (95% CI 66%-88%) for COL (p > 0.07). There was a percentage reduction of 75% in the AK count of the forearms treated with 5-FU (95% CI 66%-83%) and 64% in those treated with COL (95% CI 55%-72%). Regarding FPS and AKSS, there was improvement in both groups, with no difference regarding FPS (p = 0.654), and 5-FU superiority for AKSS (p = 0.012). STUDY LIMITATIONS: Single-center study. CONCLUSIONS: 5-FU and COL are effective for treating CFC, with neither showing superiority regarding the reduction in AK counts.

Embryonic alcohol exposure alters cholinergic neurotransmission and memory in adult zebrafish.

Alcohol is the most consumed addictive substance worldwide that elicits multiple health problems. Consumption of alcoholic beverages by pregnant women is of great concern because pre-natal exposure can trigger fetal alcohol spectrum disorder (FASD). This disorder can significantly change the embryo's normal development, mainly by affecting the central nervous system (CNS), leading to neurobehavioral consequences that persist until adulthood. Among the harmful effects of FASD, the most reported consequences are cognitive and behavioral impairments. Alcohol interferes with multiple pathways in the brain, affecting memory by impairing neurotransmitter systems, increasing the rate of oxidative stress, or even activating neuroinflammation. Here, we aimed to evaluate the deleterious effects of alcohol on the cholinergic signaling and memory in a FASD zebrafish model, using inhibitory avoidance and novel object recognition tests. Four months after the embryonic exposure to ethanol, the behavioral tests indicated that ethanol impairs memory. While both ethanol concentrations tested (0.5 % and 1 %) disrupted memory acquisition in the inhibitory avoidance test, 1 % ethanol impaired memory in the object recognition test. Regarding the cholinergic system, 0.5 % ethanol decreased ChAT and AChE activities, but the relative gene expression did not change. Overall, we demonstrated that FASD model in zebrafish impairs memory in adult individuals, corroborating the memory impairment associated with embryonic exposure to ethanol. In addition, the cholinergic system was also affected, possibly showing a relation with the cognitive impairment observed.

The critical success factors' investigation during knowledge management implementation within SME enterprises: a Participatory Design opportunity.

Knowledge management (KM) is currently an important driver to develop dynamic capabilities for businesses, on behalf of competitiveness. Nonetheless, some critical success factors are hampering KM implementation, such as a lack of a KM strategy, cultural aspects, leadership, and technology. In this paper, we focused on the KM implementation within Small and Medium Enterprises (SMEs) by exploring Participatory Design potential to KM implementation in SMEs, by focusing on information technology as a critical success factor and exploring some organizational culture characteristics that can help in this context. To achieve this goal, we conducted an ethnographic study in the real environment of a consulting firm which is starting its own KM project. Our results show that Participatory Design might be recommended to SMEs' KM implementation, by taking advantage of already available, but underused technological tools.

"We want to hug a friend": the covid-19 pandemic among low-income adolescents.

OBJECTIVE: To examine the perceptions of adolescent students from a public school, of both sexes, living in a peripheral region of the city of São Paulo, Brazil, in relation to the covid-19 pandemic, with a special focus on their experiences regarding education and sociability. METHODS: This study is part of the Global Early Adolescent Study. Seven face-to-face focus groups were conducted with adolescents between 13 and 16 years old (19 girls and 15 boys) in 2021. RESULTS: The experience of remote teaching was frustrating for the adolescents, without the daily and personalized monitoring of the teacher(s). In addition to the difficult or impossible access to devices and the lack of support from schools, there is also the domestic environment, which made the schooling process more difficult, especially for girls, who were forced to take on more household and family care tasks. The closed school blocked an important space for socialization and forced family interaction, generating conflicts and stress in the home environment. The abrupt rupture brought feelings of fear, uncertainty, anguish and loneliness. The iterative evocation of the words "stuck", "alone" and "loneliness" and the phrase "there was no one to talk to" shows how most of the adolescents experienced the period of distancing. The pandemic aggravated the objective and subjective conditions of preexisting feelings, such as "not knowing the future" and the prospects of a life project. CONCLUSION: It has been documented how pandemic control measures implemented in a fragmented way and without support for the most impoverished families have negative effects on other spheres of life, in particular for poor young people. The school is a privileged territory to propose/construct actions that help adolescents to deal with problems aggravated in/by the pandemic.

Short-term Cafeteria Diet Is Associated with Fat Mass Accumulation, Systemic and Amygdala Inflammation, and Anxiety-like Behavior in Adult Male Wistar Rats.

Obesity is linked to metabolic, hormonal and biochemical alterations, and is also a risk factor for behavioral disorders. Evidence suggests that these disorders may be related to the consumption of hypercaloric diets, fat mass accumulation and changes in inflammation and redox status. Although much is known about the chronic effects of hypercaloric diets on mental health, few studies have evaluated the consequences of short-term exposure of these diets on behavior. The aim of this study was to evaluate nutritional, behavioral (anxiety-like), inflammatory and redox status parameters in adult male Wistar rats exposed to short-term cafeteria diet. Adult Wistar male rats (90 days-old; n = 12/group) received, during 14 days, the diets: Control- standard diet; Simple Cafeteria Diet (SCD)- homogeneous cafeteria diet. Varied Cafeteria Diet (VCD)- cafeteria diet with rotation and variation. Nutritional analyzes and tests for anxiety-like behaviors were performed, in addition to inflammatory and redox status measurements in blood and amygdala. The SCD group showed higher fat energy intake, while the VCD group consumed more energy from carbohydrates. SCD and VCD showed higher fat mass accumulation, in addition to higher levels of TNFα, INFγ, TBARS and FRAP in the blood. Also, SCD and VCD groups reported high levels of TNFα in the amygdala. Regarding behavioral evaluations, SCD and VCD groups showed anxiogenesis in the elevated plus maze, light-dark box, and open field tests. Therefore, the two cafeteria diets induced obesity and systemic inflammation, which in turn, resulted in an increase in amygdala TNFα levels and anxiety-like behaviors in Wistar rats.

Prenatal LPS exposure increases hippocampus IL-10 and prevents short-term memory loss in the male adolescent offspring of high-fat diet fed dams.

Lipopolysaccharide (LPS) tolerance can reduce the neuroinflammation caused by high fat maternal diets; however, there are no reports that have evaluated the effects of prenatal LPS exposure on the memories of the offspring of high-fat diet fed dams. This study evaluated the effects of prenatal LPS exposure on the inflammatory parameters and redox status in the brain, as well as the object recognition memory of adolescent offspring of Wistar rat dams that were treated with a high-fat diet during gestation and lactation. Female pregnant Wistar rats randomly received a standard diet (17.5% fat) or a high-fat diet (45.0% fat) during gestation and lactation. On gestation days 8, 10, and 12, half of the females in each group were intraperitoneally treated with LPS (0.1 mg.kg-1). After weaning, the male offspring were placed in cages in standard conditions, and at 6 weeks old, animals underwent the novel object recognition test (for short- and long-term memory). The offspring of the high-fat diet fed dams showed increased hippocampus IL-6 levels (21-days-old) and impaired short-term memories. These effects were avoided in the offspring of high-fat diet fed dams submitted to prenatal LPS exposure, which showed greater hippocampus IL-10 levels (at 21- and 50-days-old), increased antioxidant activity (50-days-old) in the hippocampus and prefrontal cortex, without memory impairments (short- and long-term memory). IL-6 has been consistently implicated in memory deficits and as an endogenous mechanism for limiting plasticity, while IL-10 regulates glial activation and has a strong association with improvements in cognitive function. Prenatal LPS exposure preventing the increase of IL-6 in the hippocampus and the impairment to short-term object recognition memory caused by the high-fat maternal diet.

Social isolation and its impact on child and adolescent development: a systematic review.

OBJECTIVE: This study aims to analyze the effects of social isolation on children's and teenagers' development, with emphasis on the possible impacts over their physical and mental health. DATA SOURCE: Review of the literature following the standards of PRISMA using the SciELO, LILACS and PubMed databases. The following key-words were used: "social isolation" and "child development", "quarantine" and "adolescent development" according to the Medical Subject Headings (MESH) and their translation to the Portuguese. Studies in English, Portuguese and Spanish from inception were included. DATA SYNTHESIS: 519 studies were screened and 12 were included in the systematic review. Five of those focused the psychology and social issues, two of them the effects of pandemics on these issues; four studies reported on impacts on general health and two consequences over the hypothalamus- hypophysis - adrenal axis and the cognitive and social development. CONCLUSIONS: The review shows a strong association between social isolation and anxiety and depression in children and adolescents. Social isolation leads to higher levels of cortisol and worse cognitive development. Therefore, the mental and physical health of children and adolescents need a careful follow up by health professionals during and after the COVID-19 pandemic.

Concurrent Validation and Reference Values of Gluteus Medius Clinical Test.

CONTEXT: The hip abductor muscles, mainly the gluteus medius, are responsible for controlling hip adduction in a closed kinetic chain. Frontal plane knee alignment, assessed during functional activities such squatting, jumping and running, may overload joint structures, like the anterior cruciate ligament and patellofemoral joint. The hand-held dynamometer is reliable and effective for testing the muscular strength of the hip abductors. OBJECTIVES: 1. To assess the concurrent validity between the gluteus medius clinical test and a maximum isometric force test of the hip abductors using the hand-held dynamometer; (2) to determine the intra and inter-examiner reliability for the application of the gluteus medius clinical test; and (3) to describe reference values of gluteus medius clinical test on a population of youth athletes. DESIGN: Cross-sectional. METHODS: Thirty healthy individuals were recruited for validity and reliability testing. On the first day, participants performed the maximal isometric test of the hip abductors, measured via hand-held dynamometry. On the following week, the gluteus medius clinical test was performed. Intraclass correlation coefficients (ICC2,2) were computed for the reliability analysis, with a 95% confidence interval. To generate reference values, the gluteus medius clinical test was performed on 273 athletes. RESULTS: The results of this study indicated a weak positive correlation (r = 0.436, p = 0.001) between tests, which indicates that they examine different domains of gluteus medius muscle function, likely endurance and muscle strength. The magnitude of computed ICCs (>0.95) indicates excellent intra- and inter-examiner reliability. CONCLUSION: The findings of the current study indicate that the gluteus medius clinical test is reliable and examines a domain of muscular function not fully captured by HHD. The clinical test developed in this study is low-cost and can be included for gluteus medius assessment. LEVEL OF EVIDENCE: Level 3.

Caloric restriction or cafeteria diet from birth to adulthood increases the sensitivity to ephedrine in anxiety and locomotion in Wistar rats.

INTRODUCTION: Obesity and undernutrition, consequences of malnutrition, have been linked to the development of mental illnesses. Both states have been linked to increased sensitivity to some drugs, but there are few data for this association considering drugs with noradrenergic-dopaminergic action. OBJECTIVE: To evaluate the nutritional status of animals treated with either a caloric restriction (CR) or cafeteria (CAF) diet from birth and their behavior after ephedrine application. METHODS: During the lactation period, 12 litters of Wistar rats (dam + 8 pups) were fed one of three diets: control (n = 4), CR (n = 4), and CAF (n = 4). After weaning, the males were placed in individual boxes and received the same diet as their respective dams. Nutritional assessments were performed after weaning and in adulthood. In adulthood, males received either saline or ephedrine (20 mg/kg) and underwent behavioral tests including the elevated plus-maze, open-field, and food intake tests. RESULTS: The CR group exhibited higher serum high-density lipoprotein (HDL) levels and lower food and caloric intake, weight gain, and fat mass than the control group. The CAF group exhibited lower food intake and higher fat caloric intake, fat mass, and serum low-density lipoprotein (LDL), triglyceride, total cholesterol, and hepatic lipid levels than the control group. These results indicated that the CR and CAF groups had developed undernutrition and obesity, respectively. In the elevated plus-maze and open-field tests, the CR and CAF groups showed lower anxiety-like behaviors than the control group after ephedrine application. This result indicates that the animal's nutritional status (undernutrition or obesity) can enhance ephedrine sensitivity. CONCLUSION: The CR group exhibited undernutrition, whereas the CAF group exhibited obesity. Ephedrine altered anxiety and locomotion in animals that received the CR and CAF diets in manner different than that observed in animals receiving the standard diet.

LPS tolerance prevents anxiety-like behavior and amygdala inflammation of high-fat-fed dams' adolescent offspring.

Maternal high-fat diets (HFD) can generate inflammation in the offspring's amygdala, which can lead to anxiety-like behaviors. Conversely, lipopolysaccharide (LPS) tolerance can reduce neuroinflammation in the offspring caused by maternal high-fat diets. This study evaluated the combination of LPS tolerance and high-fat maternal diet on amygdala's inflammatory parameters and the anxiety-like behavior in adolescent offspring. Female pregnant Wistar rats received randomly a standard diet or a high-fat diet during gestation and lactation. On gestation days 8, 10, and 12, half of the females in each group were intraperitonially injected with LPS (0.1 mg.kg-1). After weaning, the male offspring (n = 96) were placed in individual boxes in standard conditions, and when 6 weeks-old, the animals underwent: Open-Field, Light/Dark Box, Elevated Plus-Maze, and Rotarod tests. When 50 days-old the offspring were euthanized and the amygdala removed for cytokine and redox status analysis. The offspring in the HFD group showed lower amygdala IL-10 levels, high IL-6/IL-10 ratio, and anxiety-like behaviors. These effects were attenuated in the HFD offspring submitted to LPS tolerance, which showed an anti-inflammatory compensatory response in the amygdala. Also, this group showed a higher activity of the enzyme catalase in the amygdala. In addition, receiving the combination of LPS tolerance and maternal HFD did not lead to anxiety-like behavior in the offspring. The results suggest that LPS tolerance attenuated amygdala inflammation through an anti-inflammatory compensatory response besides preventing anxiety-like behavior caused by the high-fat maternal diet.

Cafeteria diet administered from lactation to adulthood promotes a change in risperidone sensitivity on anxiety, locomotion, memory, and social interaction of Wistar rats.

PURPOSE: To evaluate the nutritional status and behavior of animals fed a cafeteria diet from the onset of lactation after the addition of risperidone. METHODS: During the lactation period, 14 litters of Wistar rats (dam + 8 pups) were fed one of two diets: control (CTRL; n = 7) or cafeteria (CAF; n = 7). After weaning, the males were placed in individual cages, receiving the same diet as offered to their respective dams. Food and caloric intake, body weight, feed and energy efficiency, and adipose tissue weight were evaluated in the male offspring. In adulthood, they were assigned to receive treatment with saline (CTRL-S, CAF-S) or risperidone (CTRL-R, CAF-R) (n = 21 in each group). They then underwent behavioral testing, which included the elevated plus maze, open field, object recognition, and social interaction tests. Variance analysis (ANOVA) was used, followed by Newman-Keuls when p-values were < 0.05. RESULTS: The CAF group exhibited higher caloric intake, weight gain, feed efficiency, and adipose tissue than the CTRL group. The animals in the CAF group exhibited oxidative stress characteristics in the hippocampus, which may have compromised the function of this structure and promoted behavioral changes. The CAF-S group exhibited anxiety, as indicated by the greater number of entrances and time spent in the center of the open field. They also showed greater locomotion through a greater number of quadrants traveled. CAF-S animals also demonstrated memory impairments, assessed using the object recognition test, and decreased social interaction. The CAF-R group demonstrated anxiety and decreased locomotion in the open field. There was a decrease in their interaction with both objects in the object recognition test. The CAF-R group obtained greater sociability in the social interaction test. Such effects may be associated with changes in the serotonergic system of these animals. CONCLUSION: Risperidone administered to animals on a cafeteria diet led to a greater reduction in locomotion, had an anxiogenic effect, caused impaired memory, and improved social interaction.

Efficacy and safety of 0.5% colchicine cream versus 5% 5-fluorouracil cream in the treatment of cutaneous field cancerization: a randomized clinical trial

Abstract Background 5-Fluorouracil (5-FU) is a first-line drug to treat cutaneous field cancerization (CFC). There are few clinical trials with topical colchicine (COL). Objective To evaluate the effectiveness of 0.5% COL cream versus 5% 5-FU cream in the treatment of CFC. Method This was a randomized, open, self-controlled clinical trial. Forty-five patients (90 forearms), with three to ten actinic keratoses (AK) on each forearm, used 0.5% COL cream 2×/day for seven days on one forearm, and 5% 5-FU cream 2× /day, for 21 days, on the other forearm. The dosages were defined based on previous clinical trials for each drug. Adverse effects were evaluated after 14 days and outcomes after 90 days of inclusion. The primary outcome was complete AK clearance and the secondary outcomes were: partial clearance (≥50%), reduction in AK count, assessment of the Forearm Photoaging Scale (FPS), AK Severity Score (AKSS), and adverse effects. Results After 90 days, there was complete clearance of AK in 37% (95% CI 24%-49%) and partial clearance in 85% (95% CI 76%-93%) of the forearms treated with 5-FU,versus 17% (95% CI 7%-27%) and 78% (95% CI 66%-88%) for COL (p > 0.07). There was a percentage reduction of 75% in the AK count of the forearms treated with 5-FU (95% CI 66%-83%) and 64% in those treated with COL (95% CI 55%-72%). Regarding FPS and AKSS, there was improvement in both groups, with no difference regarding FPS (p = 0.654), and 5-FU superiority for AKSS (p = 0.012). Study limitations Single-center study. Conclusions 5-FU and COL are effective for treating CFC, with neither showing superiority regarding the reduction in AK counts.

Cat-transmitted cutaneous lymphatic sporothricosis.

Sporotrichosis is the most common of the deep mycoses. In most cases the transmission occurs secondary to recent penetrating trauma with plant thorns, wood splinters or contaminated organic material. We report a case of a 68-year-old Brazilian female with a small ulcer on her right forefinger and palpable erythematous nodules on her right forearm. These occurred after the bite of a domestic cat that had a lesion on its hind-foot. Since the 1980s, the role of felines in the transmission of this mycosis to humans has gained attention among animal owners, veterinarians, and caretakers. Humans can be contaminated by a cat scratch or bite and even by contact with contaminated solutions.

"We want to hug a friend": the covid-19 pandemic among low-income adolescents / "A gente quer abraçar o amigo": a pandemia de covid-19 entre adolescentes de baixa renda

ABSTRACT OBJECTIVE To examine the perceptions of adolescent students from a public school, of both sexes, living in a peripheral region of the city of São Paulo, Brazil, in relation to the covid-19 pandemic, with a special focus on their experiences regarding education and sociability. METHODS This study is part of the Global Early Adolescent Study. Seven face-to-face focus groups were conducted with adolescents between 13 and 16 years old (19 girls and 15 boys) in 2021. RESULTS The experience of remote teaching was frustrating for the adolescents, without the daily and personalized monitoring of the teacher(s). In addition to the difficult or impossible access to devices and the lack of support from schools, there is also the domestic environment, which made the schooling process more difficult, especially for girls, who were forced to take on more household and family care tasks. The closed school blocked an important space for socialization and forced family interaction, generating conflicts and stress in the home environment. The abrupt rupture brought feelings of fear, uncertainty, anguish and loneliness. The iterative evocation of the words "stuck", "alone" and "loneliness" and the phrase "there was no one to talk to" shows how most of the adolescents experienced the period of distancing. The pandemic aggravated the objective and subjective conditions of preexisting feelings, such as "not knowing the future" and the prospects of a life project. CONCLUSION It has been documented how pandemic control measures implemented in a fragmented way and without support for the most impoverished families have negative effects on other spheres of life, in particular for poor young people. The school is a privileged territory to propose/construct actions that help adolescents to deal with problems aggravated in/by the pandemic.

RESUMO OBJETIVO Examinar as percepções de adolescentes estudantes de uma escola pública, de ambos os sexos, moradores de uma região periférica da cidade de São Paulo, Brasil, em relação à pandemia de covid-19, com especial enfoque em suas experiências quanto à educação e sociabilidade. MÉTODOS Este estudo faz parte do Global Early Adolescent Study. Foram conduzidos sete grupos focais presenciais com adolescentes entre 13 e 16 anos (19 meninas e 15 meninos),em 2021. RESULTADOS A experiência do ensino remoto foi frustrante para as/os adolescentes, sem o acompanhamento cotidiano e personalizado de professoras(es). Ao acesso difícil ou impossível aos dispositivos e à ausência de suporte das escolas é acrescido o ambiente doméstico, que dificultou o processo de escolarização, em especial para as meninas, obrigadas a assumir mais tarefas de cuidado da casa e da família. A escola fechada bloqueou espaço importante de socialização e forçou o convívio familiar, gerando conflitos e estresse. A abrupta ruptura trouxe sentimentos de medo, incerteza, angústia e solidão. A evocação iterativa das palavras "presa/o", "sozinha/o" e "solidão" e da frase "não teve ninguém pra conversar" mostra como grande parte das/os adolescentes experienciou o período de distanciamento. A pandemia agravou as condições objetivas e subjetivas de sentimentos preexistentes, como "não saber o futuro" e as perspectivas de projeto de vida. CONCLUSÃO Foi documentado como medidas de controle da pandemia implementadas de forma fragmentada e sem suporte às famílias mais empobrecidas têm efeitos negativos em outras esferas da vida, em particular para jovens pobres. A escola é um território privilegiado para se propor/construir ações que auxiliem as/os adolescentes a lidar com problemas agravados na/pela pandemia.

Social isolation and its impact on child and adolescent development: a systematic review / Isolamento social e seu impacto no desenvolvimento de crianças e adolescentes: uma revisão sistemática

ABSTRACT Objective: This study aims to analyze the effects of social isolation on children's and teenagers' development, with emphasis on the possible impacts over their physical and mental health. Data source: Review of the literature following the standards of PRISMA using the SciELO, LILACS and PubMed databases. The following key-words were used: "social isolation" and "child development", "quarantine" and "adolescent development" according to the Medical Subject Headings (MESH) and their translation to the Portuguese. Studies in English, Portuguese and Spanish from inception were included. Data synthesis: 519 studies were screened and 12 were included in the systematic review. Five of those focused the psychology and social issues, two of them the effects of pandemics on these issues; four studies reported on impacts on general health and two consequences over the hypothalamus- hypophysis - adrenal axis and the cognitive and social development. Conclusions: The review shows a strong association between social isolation and anxiety and depression in children and adolescents. Social isolation leads to higher levels of cortisol and worse cognitive development. Therefore, the mental and physical health of children and adolescents need a careful follow up by health professionals during and after the COVID-19 pandemic.

RESUMO Objetivo: Analisar os efeitos do isolamento social para o desenvolvimento de crianças e adolescentes, considerando consequências em médio e longo prazos, e entender possíveis impactos sobre a saúde mental e física. Fontes de dados: Revisão sistemática da literatura seguindo os parâmetros da lista Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) nas bases de dados Scientific Electronic Library Online (SciELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e PubMed. Os descritores utilizados foram "social isolation" AND "child development", "quarantine" AND "child development", "social isolation" AND "adolescent development", "quarantine" AND "adolescent development" de acordo com o Medical Subject Headings (MeSH) e seus equivalentes para a língua portuguesa, conforme os Descritores em Ciências da Saúde (DeCS). Incluíram-se artigos originais em inglês, português e espanhol, sem delimitação temporal. Síntese dos dados: Identificaram-se 519 referências, e, após critérios de inclusão e exclusão, 12 artigos foram analisados. Cinco abordaram a questão psicossocial (sendo dois sobre os efeitos das pandemias), quatro sobre os impactos na saúde em geral, dois sobre consequências no eixo hipotálamo-hipófise-adrenal e um sobre o desenvolvimento cognitivo e social. Conclusões: Os artigos revisados evidenciaram forte relação entre isolamento social e maior incidência de sentimentos como ansiedade e depressão na população de crianças e adolescentes. Além disso, identificaram-se aumento nos níveis de cortisol e piora no desenvolvimento cognitivo dessa faixa etária. Logo, o acompanhamento da saúde mental e física desses jovens por profissionais da saúde deve estar presente durante e após a pandemia.

Impactos da COVID-19 nos pacientes oncológicos: uma revisão sistemática / Impacts of COVID-19 on cancer patients: a systematic review

Introdução: Com a pandemia de coronavírus os pacientes oncológicos, que estão em tratamentos, nos quais a maioria são imunossupressores, se tornaram um grupo muito suscetível a formas graves da infecção. Logo, como forma de proteção e prevenção, a realização de exames de rastreio no ambiente hospitalar foi restringida, atrasando diversos diagnósticos e comprometendo a eficácia de tratamentos. Objetivos: Analisar a produção científica acerca do tema câncer e COVID-19, a fim de contribuir com informações sobre o assunto. Métodos: Revisão sistemática da literatura nas bases de dados SciELO, LILACS e PubMed. Os descritores utilizados foram "câncer" AND "COVID-19" de acordo com o Medical Subject Headings (MeSH) e seus equivalentes para a língua portuguesa, conforme os descritores de Ciências da Saúde (DeCS). Foram incluídos artigos originais em inglês e português, sem delimitação temporal. Resultados: Foram encontrados 1.606 artigos e, após utilizar os critérios de inclusão e exclusão, nove foram incluídos para análise na revisão. Dentre os temas centrais abordados pelos estudos selecionados estão o impacto da pandemia em algumas áreas de acompanhamento do paciente oncológico, como: tratamento, telemedicina, diminuição de funcionários no atendimento ao paciente com câncer, diminuição dos ensaios clínicos, redução dos recursos financeiros e apoio psicológico a essa população. Conclusão: A pandemia afetou diretamente o modo de vida desse grupo, que sofreu com uma redução no atendimento médico e nos recursos dispostos a eles. Portanto, nota-se a necessidade de prestar um cuidado mais específico a esses pacientes em situação tão delicada durante a pandemia.

Introduction: During the coronavirus pandemic, oncological patients, who are undergoing treatments in which the majority are immunosuppressant, have become a group very susceptible to severe forms of the infection. Therefore, as a form of protection, their going to hospital environments were restricted, delaying diagnosis and compromising the effectiveness of treatments. Objectives: This study aims to analyze the scientific about the production of the theme cancer and COVID-19 in order to contribute with informations on the subject. Methods: Systematic review of literature using the SciELO, LILACS and PubMed. The following keywords were used: "cancer" AND "COVID-19" according to the Medical Subject Headings (MeSH) and their translation to the Portuguese. Studies in English and Portuguese from inception were included. Results: 1,606 studies were screened and 9 were included in the systematic review after using the inclusion and exclusion criterias. Among the central themes addressed by the selected studies are the pandemic impacts in areas of monitoring oncological patients, such as: treatment, telemedicine, reduction of employees in the care of cancer patients, reduction of clinical trials, reduction of financial resources, and psychological support to that population. Conclusion: The pandemic directly affected the way of life of this group, which suffered from a reduction in medical care and the resources available to them. Therefore, there is a need to provide more specific care to these patients in such a delicate situation during the pandemic.

Exercise Training Improved Pulmonary Gas Exchange Abnormalities in Pulmonary Hypertension due to Heart Failure: A Case Report

Abstract Heart failure (HF) is the most common cause of pulmonary hypertension (PH), and reduced exercise capacity and exertional dyspnea are the most frequent concerns in patients with PH-HF. Indeed, carbon dioxide end-tidal partial pressure (PETCO 2 ) during exercise is a well-established noninvasive marker of ventilation/perfusion ratio in PH. We aimed to evaluate the effect of aerobic exercise training on PETCO 2 response during exercise in a 59-year-old woman with PH secondary to idiopathic dilated cardiomyopathy. The patient with chronic fatigue and dyspnea at mild-to-moderate efforts was admitted to a cardiorespiratory rehabilitation program and had her cardiorespiratory response to exercise assessed during a cardiopulmonary exercise testing performed before and after three months of a thrice-weekly aerobic exercise training program. Improvements in aerobic capacity (23.9%) and endurance time (37.5%) and reduction in ventilatory inefficiency (-20.2%) was found after intervention. Post-intervention improvements in PETCO 2 at ventilatory anaerobic threshold (23.3%) and change in PETCO 2 kinetics pattern, with progressive increases from rest to peak of exercise, were also found. Patient also improved breathing pattern and timing of ventilation. This case report demonstrated for the first time that aerobic exercise training might be able to improve PETCO 2 response during exercise in a patient with PH-HF.

Fasciite nodular na fronte: uma rara apresentação / Nodular fasciitis in the forehead: a rare presentation

A fasciite nodular é um tumor benigno, decorrente da proliferação reativa de células fibroblásticas ou miofibroblásticas de rápido crescimento e rica celularidade. Em adultos, o acometimento das extremidades é mais frequente; entretanto, outras regiões podem ser acometidas. Neste relato, é apresentada paciente feminina de 40 anos, com lesão nodular na fronte, com diagnóstico de fasciite nodular confirmado à histopatologia. O caso relatado procura destacar sua rara localização e alertar o dermatologista clínico para a sua inclusão entre os diagnósticos diferenciais das lesões tumorais na face.

Nodular fasciitis is a benign tumor resulting from the reactive proliferation of fibroblastic or myofibroblastic cells presenting rapid growth and rich cellularity. In adults, the extremities' involvement is more frequent; however, other regions can be affected. In this report, we present the case of a 40-year-old woman with a nodular lesion on the forehead. The histopathology confirmed the diagnosis of nodular fasciitis. The reported case highlights its rare location and alerts the clinical dermatologist in its inclusion among the differential diagnoses of tumor lesions on the face.

Tuberculose: conhecimento e adesão às medidas profiláticas em indivíduos contatos da cidade do Recife, Pernambuco, Brasil / Tuberculosis: knowledge and adherence to prophylactic measures in contact individuals of the city of Recife, Pernambuco, Brazil

Resumo Introdução Para o controle da tuberculose, é fundamental interromper a cadeia de transmissão da doença. O Ministério da Saúde preconiza que 100% dos contatos sejam examinados e iniciem tratamento da Infecção Latente por Mycobacterium tuberculosis. Nesse sentido, o conhecimento sobre a doença e a adesão à profilaxia por parte desses contatos são fatores que podem interferir no adequado controle da tuberculose. Objetivo Descrever o conhecimento dos contatos de portadores de tuberculose sobre a doença e sua adesão às medidas profiláticas no Distrito Sanitário II em Recife/PE. Método Estudo quantitativo, descritivo, utilizando questionários padronizados, aplicados a 140 contatos de tuberculose notificados de janeiro a dezembro de 2015. Análise dos dados realizada por meio de frequências simples. Resultados Dentre os entrevistados, 75,7% eram do sexo feminino, 55% pardos, com baixos níveis de escolaridade e renda familiar. Destes, 84,3% acreditam que a tuberculose é grave, 48,6% consideram que a transmissão se faz compartilhando utensílios. Apenas 55% foram convidados para serem examinados e 76% referiram não saber que deveriam ir à consulta ou a importância desta. Conclusão Os contatos de tuberculose possuem precário conhecimento sobre a doença, baixa adesão à atenção primária à saúde e a busca ativa dos contatos ainda é ineficiente.

Abstract Background For the control of tuberculosis, it is essential to interrupt its chain of transmission. The Ministry of Health recommends 100% of contacts being examined and initiated treatment of the Latent Mycobacterium tuberculosis infection. In this sense, the knowledge about the disease and adherence to prophylaxis by these contacts are factors that can interfere in the adequate control of tuberculosis. Objective To describe the knowledge of the contacts of tuberculosis patients on the disease and their adherence to prophylactic measures in the Sanitary District II in Recife / PE. Method A quantitative and descriptive study was carried out using standardized questionnaires, applied to 140 contacts of tuberculosis notified from January to December 2015. Data analysis carried out through simple frequencies. Results Among the interviewees, 75.7% were female, 55% brown, with low levels of schooling and family income; of these 84.3% believe that tuberculosis is serious, 48.6% consider that transmission is done by sharing utensils. Only 55% were invited to be examined and 76% reported not knowing they should go to the consultation or the importance of these. Conclusion The contacts of tuberculosis have poor knowledge about the disease, low adherence to primary health care and the active search for contacts is still inefficient.