Detalhe da pesquisa
1.
A Mechanistic Understanding of Monoclonal Antibody Interfacial Protection by Hydrolytically Degraded Polysorbate 20 and 80 under IV Bag Conditions.
Pharm Res
; 39(3): 563-575, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35277841
2.
Evaluating a Modified High Purity Polysorbate 20 Designed to Reduce the Risk of Free Fatty Acid Particle Formation.
Pharm Res
; 38(9): 1563-1583, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34495486
3.
Improving Prediction of Free Fatty Acid Particle Formation in Biopharmaceutical Drug Products: Incorporating Ester Distribution during Polysorbate 20 Degradation.
Mol Pharm
; 17(11): 4354-4363, 2020 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32941040
4.
Characterization of Polysorbate Ester Fractions and Implications in Protein Drug Product Stability.
Mol Pharm
; 17(7): 2345-2353, 2020 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32442382
5.
Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes.
Proc Natl Acad Sci U S A
; 110(8): 3077-82, 2013 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23365139
6.
Polysorbate 20 Degradation in Biopharmaceutical Formulations: Quantification of Free Fatty Acids, Characterization of Particulates, and Insights into the Degradation Mechanism.
Mol Pharm
; 12(11): 3805-15, 2015 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26419339
7.
Characterization of Recombinantly-Expressed Hydrolytic Enzymes from Chinese Hamster Ovary Cells: Identification of Host Cell Proteins that Degrade Polysorbate.
J Pharm Sci
; 112(5): 1351-1363, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36646283
8.
Extended Characterization and Impact of Visible Fatty Acid Particles - A Case Study With a mAb Product.
J Pharm Sci
; 110(3): 1093-1102, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33271136
9.
Identification and Characterization of Polysorbate-Degrading Enzymes in a Monoclonal Antibody Formulation.
J Pharm Sci
; 110(11): 3558-3567, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34224732
10.
Micellar Morphology of Polysorbate 20 and 80 and Their Ester Fractions in Solution via Small-Angle Neutron Scattering.
J Pharm Sci
; 109(4): 1498-1508, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31887262
11.
A Rapid High-Sensitivity Reversed-Phase Ultra High Performance Liquid Chromatography Mass Spectrometry Method for Assessing Polysorbate 20 Degradation in Protein Therapeutics.
J Pharm Sci
; 108(9): 2880-2886, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31054888
12.
Novel markers to track oxidative polysorbate degradation in pharmaceutical formulations.
J Pharm Biomed Anal
; 157: 201-207, 2018 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29803911
13.
An information theoretic framework reveals a tunable allosteric network in group II chaperonins.
Nat Struct Mol Biol
; 24(9): 726-733, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28741612
14.
Prenatal corticosteroid therapy for elevated liver enzyme/low platelet count syndrome: a case report.
J Reprod Med
; 50(1): 64-6, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15730178