Detalhe da pesquisa
1.
The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
Nat Rev Immunol
; 21(9): 548-569, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33833439
2.
Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold.
Bioorg Med Chem Lett
; 20(22): 6754-7, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20869872
3.
The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine.
J Pharmacol Exp Ther
; 328(3): 921-30, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19088300
4.
Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.
Bioorg Med Chem Lett
; 19(19): 5803-6, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19713111
5.
The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.
Bioorg Med Chem Lett
; 18(11): 3386-91, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18455394
6.
Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.
J Med Chem
; 48(24): 7520-34, 2005 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16302794
7.
A novel class of nonpeptidic biaryl inhibitors of human cathepsin K.
J Med Chem
; 46(17): 3709-27, 2003 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-12904076
8.
Structure-based design of ß-site APP cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease.
J Med Chem
; 56(11): 4156-80, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23509904
9.
Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K.
Bioorg Med Chem Lett
; 16(16): 4296-9, 2006 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16750630
10.
Influence of acid surrogates toward potency of VLA-4 antagonist.
Bioorg Med Chem Lett
; 15(18): 4053-6, 2005 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16039122
11.
Novel route to the synthesis of peptides containing 2-amino-1'-hydroxymethyl ketones and their application as cathepsin K inhibitors.
Bioorg Med Chem Lett
; 12(20): 2887-91, 2002 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12270170
12.
Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the alpha 2 delta-1 subunit of voltage gated calcium channel.
Bioorg Med Chem Lett
; 14(10): 2463-7, 2004 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15109633
13.
An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells.
Anal Biochem
; 335(2): 218-27, 2004 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15556560
14.
N-Acridin-9-yl-butane-1,4-diamine derivatives: high-affinity ligands of the alpha2delta subunit of voltage gated calcium channels.
Bioorg Med Chem Lett
; 14(8): 1913-6, 2004 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15050626
15.
Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives as high-affinity ligands of the alpha(2)delta subunit of voltage-gated calcium channels.
Bioorg Med Chem Lett
; 14(9): 2031-4, 2004 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15080973