Detalhe da pesquisa
1.
Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Bioorg Med Chem Lett
; 24(20): 4884-90, 2014 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25248679
2.
Outcomes of Injured Patients Before and After the Institution of a Third-Tier Activation at a Level 1 Trauma Center.
Am Surg
; 90(3): 427-435, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-37703078
3.
Impact of Frailty in Patients Undergoing Minimally Invasive Mitral Valve Surgery.
Innovations (Phila)
; 19(1): 64-71, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38284330
4.
Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).
Bioorg Med Chem Lett
; 23(24): 6620-4, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24215892
5.
Interest of the MGAP score on in-hospital trauma patients: Comparison with TRISS, ISS and NISS scores.
Injury
; 53(9): 3059-3064, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-35623955
6.
Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
Bioorg Med Chem Lett
; 18(19): 5307-10, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18774711
7.
8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 17(23): 6511-5, 2007 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17931865
8.
Analysis of Profit and Loss by Injury Severity over 20 Years at a University Level I Trauma Center.
Am Surg
; 82(7): 644-8, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27457865
9.
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
J Med Chem
; 46(4): 453-6, 2003 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12570367
10.
Thumb amputations from team roping.
Am J Sports Med
; 31(5): 728-35, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12975194
11.
Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
ChemMedChem
; 9(2): 311-22, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24376006
12.
Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.
ChemMedChem
; 7(3): 415-24, 337, 2012 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22307992
13.
Raltegravir: the first HIV-1 integrase strand transfer inhibitor in the HIV armamentarium.
Ann N Y Acad Sci
; 1222: 83-9, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21434946
14.
Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists.
ACS Chem Neurosci
; 2(7): 352-62, 2011 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22816022
15.
Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.
J Med Chem
; 53(14): 5320-32, 2010 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20565075
16.
Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 17(20): 5595-9, 2007 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17822898
17.
A potent and orally active HIV-1 integrase inhibitor.
Bioorg Med Chem Lett
; 17(5): 1392-8, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17194584
18.
A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 16(11): 2900-4, 2006 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16554152
19.
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.
Bioorg Med Chem Lett
; 15(20): 4550-4, 2005 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16102965
20.
Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques.
Science
; 305(5683): 528-32, 2004 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15247437