Enhancing Inhalation Drug Delivery: A Comparative Study and Design Optimization of a Novel Valved Holding Chamber.

This paper presents an innovative approach to the design optimization of valved holding chambers (VHCs), crucial devices for aerosol drug delivery. We present the design of an optimal cylindrical VHC body and introduce a novel valve based on particle impaction theory. The research combines computational simulations and physical experiments to assess the performance of various VHCs, with a special focus on the deposition patterns of medication particles within these devices. The methodology incorporates both experimental and simulation approaches to validate the reliability of the simulation. Emphasis is placed on the deposition patterns observed on the VHC walls and the classification of fine and large particles for salbutamol sulfate particles. The study reveals the superior efficacy of our valve design in separating particles compared to commercially available VHCs. In standard conditions, our valve design allows over 95% of particles under 7 µm to pass through while effectively filtering those larger than 8 µm. The optimized body design accomplishes a 60% particle mass flow fraction at the outlet and an average particle size reduction of 58.5%. When compared numerically in terms of size reduction, the optimal design outperforms the two commercially available VHCs selected. This study provides valuable insights into the optimization of VHC design, offering significant potential for improved aerosol drug delivery. Our findings demonstrate a new path forward for future studies, aiming to further optimize the design and performance of VHCs for enhanced pulmonary drug delivery.

The Impact of Nozzle Opening Thickness on Flow Characteristics and Primary Electron Beam Scattering in an Environmental Scanning Electron Microscope.

This paper describes the methodology of combining experimental measurements with mathematical-physics analyses in the investigation of flow in the aperture and nozzle. The aperture and nozzle separate the differentially pumped chamber from the specimen chamber in an environmental scanning electron microscope (ESEM). Experimental measurements are provided by temperature and pressure sensors that meet the demanding conditions of cryogenic temperature zones and low pressures. This aperture maintains the required pressure difference between the chambers. Since it separates the large pressure gradient, critical flow occurs on it and supersonic gas flow with the characteristic properties of critical flow in the state variables occurs behind it. As a primary electron beam passes through the differential pumped chamber and the given aperture, the aperture is equipped with a nozzle. The shape of the nozzle strongly influences the character of the supersonic flow. The course of state variables is also strongly influenced by this shape; thus, it affects the number of collisions the primary beam's electrons have with gas molecules, and so the resulting image. This paper describes experimental measurements made using sensors under laboratory conditions in a specially created experimental chamber. Then, validation using mathematical-physical analysis in the Ansys Fluent system is described.

Mathematical Physics Analysis of Nozzle Shaping at the Gas Outlet from the Aperture to the Differentially Pumped Chamber in Environmental Scanning Electron Microscopy (ESEM).

A combination of experimental measurement preparations using pressure and temperature sensors in conjunction with the theory of one-dimensional isentropic flow and mathematical physics analyses is presented as a tool for analysis in this paper. Furthermore, the subsequent development of a nozzle for use in environmental electron microscopy between the specimen chamber and the differentially pumped chamber is described. Based on experimental measurements, an analysis of the impact of the nozzle shaping located behind the aperture on the character of the supersonic flow and the resulting dispersion of the electron beam passing through the differential pumped chamber is carried out on the determined pressure ratio using a combination of theory and mathematical physics analyses. The results show that nozzle shapes causing under-expanded gas outflow from the aperture to the nozzle have a worse impact on the dispersion of the primary electron beam. This is due to the flow velocity control. The controlled reduction in the static pressure curve on the primary electron beam path thus causes a significantly higher course of electron dispersion values than variants with shapes causing over-expanded gas outflow.

Mathematical-Physics Analyses of the Nozzle Shaping at the Aperture Gas Outlet into Free Space under ESEM Pressure Conditions.

The paper presents a methodology that combines experimental measurements and mathematical-physics analyses to investigate the flow behavior in a nozzle-equipped aperture associated with the solution of its impact on electron beam dispersion in an environmental scanning electron microscope (ESEM). The shape of the nozzle significantly influences the character of the supersonic flow beyond the aperture, especially the shape and type of shock waves, which are highly dense compared to the surrounding gas. These significantly affect the electron scattering, which influences the resulting image. This paper analyzes the effect of aperture and nozzle shaping under specific low-pressure conditions and its impact on the electron dispersion of the primary electron beam.

Muscle Constitutive Model With a Tangent Modulus Approximation: Ansys Implementation and Verification.

Sophisticated muscle material models are required to perform detailed finite element simulations of soft tissue; however, state-of-the-art muscle models are not among the built-in materials in popular commercial finite element software packages. Implementing user-defined muscle material models is challenging for two reasons: deriving the tangent modulus tensor for a material with a complex strain energy function is tedious and programing the algorithm to compute it is error-prone. These challenges hinder widespread use of such models in software that employs implicit, nonlinear, Newton-type finite element methods. We implement a muscle material model in Ansys using an approximation of the tangent modulus, which simplifies its derivation and implementation. Three test models were constructed by revolving a rectangle (RR), a right trapezoid (RTR), and a generic obtuse trapezoid (RTO) around the muscle's centerline. A displacement was applied to one end of each muscle, holding the other end fixed. The results were validated against analogous simulations in FEBio, which uses the same muscle model but with the exact tangent modulus. Overall, good agreement was found between our Ansys and FEBio simulations, though some noticeable discrepancies were observed. For the elements along the muscle's centerline, the root-mean-square-percentage error in the Von Mises stress was 0.00%, 3.03%, and 6.75% for the RR, RTR, and RTO models, respectively; similar errors in longitudinal strain were observed. We provide our Ansys implementation so that others can reproduce and extend our results.

Pedestrian Safety in Frontal Tram Collision, Part 2: Laminated Glass as a Crucial Part of the Absorption and Deformation Zone-Its Impact Test and Analysis.

As was shown in the previous part of the study, windshields are an important part of the passive safety means of modern low-floor trams with an extraordinary effect on pedestrian safety in a pedestrian-tram collisions. Therefore, maximum attention must be paid to the definition of tram windshield characteristics. This article describes a windshield crash test, from which data are obtained to verify the feasibility of the applied computational approaches. A developed analytical model is utilised for a simple description of the energy balance during collision with an illustrative definition of the important parameters of laminated glass as well as their clear physical interpretations. The finite element analysis (FEA) performed in Ansys software using two versions of material definition, namely a simpler (*MAT_ELASTIC with nonlocal failure criterion) and a more complex (*MAT_GLASS with brittle stress-state-dependent failure) material model, which are presented as suitable for obtaining a detailed description of the shattering process of laminated glass, which can also be used effectively in windshield engineering.

Ultra-Wideband Compact Fractal Antenna for WiMAX, WLAN, C and X Band Applications.

In this paper, a compact dual-wideband fractal antenna is created for Bluetooth, WiMAX, WLAN, C, and X band applications. The proposed antenna consists of a circularly shaped resonator that contains square slots and a ground plane where a gap line is incorporated to increase the gain and bandwidth with a small volume of 40 × 34 × 1.6 mm3. The patch was supported by the FR4 dielectric, which had a permittivity of 4.4 and tan δ = 0.02. A 50 Ω microstrip line fed this antenna. The antenna was designed by the HFSS program, and after that, the simulated results were validated using the measured results. The measurement results confirm that the suggested antenna achieves dual-band frequencies ranging from 2.30 to 4.10 GHz, and from 6.10 GHz to 10.0 GHz, resonating at 2.8, 3.51, 6.53, and 9.37 GHz, respectively, for various applications including commercial, scholarly, and medical applications. Moreover, the antenna's ability to operate within the frequency range of 3.1-10.6 GHz is in accordance with the FCC guidelines for the use of UWB antennas in breast cancer detection. Over the operational bands, the gain varied between 2 and 9 dB, and an efficiency of 92% was attained. A good agreement between the simulation and the measured results was found.

Impact of Supersonic Flow in Scintillator Detector Apertures on the Resulting Pumping Effect of the Vacuum Chambers.

The article describes the combination of experimental measurements with mathematical-physics analyses in flow investigation in the chambers of the scintillator detector, which is a part of the environmental scanning electron microscope. The chambers are divided with apertures by small openings that keep the desirable pressure differences between three chambers: The specimen chamber, the differentially pumped intermediate chamber, and the scintillator chamber. There are conflicting demands on these apertures. On the one hand, the diameter of the apertures must be as big as possible so that they incur minimal losses of the passing secondary electrons. On the other hand, it is possible to magnify the apertures only to a certain extent so the rotary and turbomolecular vacuum pump can maintain the required operating pressures in separate chambers. The article describes the combination of experimental measurement using an absolute pressure sensor and mathematical physics analysis to map all the specifics of the emerging critical supersonic flow in apertures between the chambers. Based on the experiments and their tuned analyses, the most effective variant of combining the sizes of each aperture concerning different operating pressures in the detector is determined. The situation is made more difficult by the described fact that each aperture separates a different pressure gradient, so the gas flow through each aperture has its own characteristics with a different type of critical flow, and they influence each other, thereby influencing the final passage of secondary electrons detected by the scintillator and thus affecting the resulting displayed image.

Comparative Analysis of Supersonic Flow in Atmospheric and Low Pressure in the Region of Shock Waves Creation for Electron Microscopy.

This paper presents mathematical-physics analyses in the field of the influence of inserted sensors on the supersonic flow behind the nozzle. It evaluates differences in the flow in the area of atmospheric pressure and low pressure on the boundary of continuum mechanics. To analyze the formation of detached and conical shock waves and their distinct characteristics in atmospheric pressure and low pressure on the boundary of continuum mechanics, we conduct comparative analyses using two types of inserted sensors: flat end and tip. These analyses were performed in two variants, considering pressure ratios of 10:1 both in front of and behind the nozzle. The first variant involved using atmospheric pressure in the chamber in front of the nozzle. The second type of analysis was conducted with a pressure of 10,000 Pa in front of the nozzle. While this represents a low pressure at the boundary of continuum mechanics, it remains above the critical limit of 113 Pa. This deliberate choice was made as it falls within the team's research focus on low-pressure regions. Although it is situated at the boundary of continuum mechanics, it is intentionally within a pressure range where the viscosity values are not yet dependent on pressure. In these variants, the nature of the flow was investigated concerning the ratio of inertial and viscous flow forces under atmospheric pressure conditions, and it was compared with flow conditions at low pressure. In the low-pressure scenario, the ratio of inertial and viscous flow forces led to a significant reduction in the value of inertial forces. The results showed an altered flow character, characterized by a reduced tendency for the formation of cross-oblique shockwaves within the nozzle itself and the emergence of shockwaves with increased thickness. This increased thickness is attributed to viscous forces inhibiting the thickening of the shockwave itself. This altered flow character may have implications, such as influencing temperature sensing with a tipped sensor. The shockwave area may form in a very confined space in front of the tip, potentially impacting the results. Additionally, due to reduced inertial forces, the cone shock wave's angle is a few degrees larger than theoretical predictions, and there is no tilting due to lower inertial forces. These analyses serve as the basis for upcoming experiments in the experimental chamber designed specifically for investigations in the given region of low pressures at the boundary of continuum mechanics. The objective, in combination with mathematical-physics analyses, is to determine changes within this region of the continuum mechanics boundary where inertial forces are markedly lower than in the atmosphere but remain under the influence of unreduced viscosity.

Analytical and Experimental Investigation of a Curved Piezoelectric Energy Harvester.

Piezoelectric energy harvesters have traditionally taken the form of base excited cantilevers. However, there is a growing body of research into the use of curved piezoelectric transducers for energy harvesting. The novel contribution of this paper is an analytical model of a piezoelectric energy harvesting curved beam based on the dynamic stiffness method (DSM) and its application to predict the measured output of a novel design of energy harvester that uses commercial curved transducers (THUNDER TH-7R). The DSM predictions are also verified against results from commercial finite element (FE) software. The validated results illustrate the resonance shift and shunt damping arising from the electrical effect. The magnitude, phase, Nyquist plots, and resonance frequency shift estimates from DSM and FE are all in satisfactory agreement. However, DSM has the advantage of having significantly fewer elements and is sufficiently accurate for commercial curved transducers used in applications where beam-like vibration is the predominant mode of vibration.

Modeling, Simulation and Implementation of All Terrain Adaptive Five DOF Robot.

The ability of an off-road robot to traverse obstacles determines whether the robot can complete complex environmental tasks. In order to improve the off-road ability of off-road robots, this paper proposes a new design idea, in which four hub motors are the power system of the robot, the steering system of the robot is composed of a steering machine and a stepping motor, and a five degree of freedom robot model is established. The body structure is designed according to the characteristics of arthropods. The body structure is divided into three modules, and the connecting rod is used as the joint system of the robot to connect the three parts. The body can deform when facing complex obstacles, so as to adapt to different terrains. Then the body structure is simplified, and a mathematical model is established to describe the mathematical relationship between body joint changes. In order to verify the ability of the adaptive all-terrain cross-country robot to traverse obstacles, the load-bearing experiment and obstacle-crossing simulation experiment were carried out through Adams software, and the continuous traversing performance at low obstacles and the ability to break through high obstacles were tested, respectively. The experimental results prove that the designed adaptive all-terrain off-road robot is feasible, has good carrying capacity, and has good passability in the face of low obstacles and high obstacles. Using Ansys software to perform finite element analysis on the wheel connection, the experimental results show that the strength meets the material strength requirements. Finally, a real vehicle test is carried out to verify the correctness of the simulation results.

Slip Flow Analysis in an Experimental Chamber Simulating Differential Pumping in an Environmental Scanning Electron Microscope.

This paper describes the combination of experimental measurements with mathematical-physical analysis during the investigation of flow in an aperture at low pressures in a prepared experimental chamber. In the first step, experimental measurements of the pressure in the specimen chamber and at its outlet were taken during the pumping of the chamber. This process converted the atmospheric pressure into the operating pressure typical for the current AQUASEM II environmental electron microscope at the ISI of the CAS in Brno. Based on these results, a mathematical-physical model was tuned in the Ansys Fluent system and subsequently used for mathematical-physical analysis in a slip flow regime on a nozzle wall at low pressure. These analyses will be used to fine-tune the experimental chamber. Once the chamber is operational, it will be possible to compare the results obtained from the experimental measurements of the nozzle wall pressure, static pressure, total pressure and temperature from the nozzle axis region in supersonic flow with the results obtained from the mathematical-physical analyses. Based on the above comparative analyses, we will be able to determine the realistic slip flow at the nozzle wall under different conditions at the continuum mechanics boundary.

Development of Force Sensor System Based on Tri-Axial Fiber Bragg Grating with Flexure Structure.

Fiber Bragg grating (FBG) sensors have an advantage over optical sensors in that they are lightweight, easy to terminate, and have a high flexibility and a low cost. Additionally, FBG is highly sensitive to strain and temperature, which is why it has been used in FBG force sensor systems for cardiac catheterization. When manually inserting the catheter, the physician should sense the force at the catheter tip under the limitation of power (<0.5 N). The FBG force sensor can be optimal for a catheter as it can be small, low-cost, easy to manufacture, free of electromagnetic interference, and is materially biocompatible with humans. In this study, FBG fibers mounted on two different flexure structures were designed and simulated using ANSYS simulation software to verify their sensitivity and durability for use in a catheter tip. The selected flexure was combined with three FBGs and an interrogator to obtain the wavelength signals. To obtain a calibration curve, the FBG sensor obtained data on the change in wavelength with force at a high resolution of 0.01 N within the 0.1-0.5 N range. The calibration curve was used in the force sensor system by the LabVIEW program to measure the unknown force values in real time.

Mini-AUV Hydrodynamic Parameters Identification via CFD Simulations and Their Application on Control Performance Evaluation.

This manuscript presents a fully detailed methodology in order to identify the hydrodynamic parameters of a mini autonomous underwater vehicle (mini-AUV) and evaluate its performance using different controllers. The methodology consists of close-to-reality simulation using a Computed Fluid Dynamics (CFD) module of the ANSYS™ Workbench software, the processing of the data, obtained by simulation, with a set of Savistky-Golay filters; and, the application of the Least Square Method in order to estimate the hydrodynamic parameters of the mini-AUV. Finally, these parameters are considered to design the three different controllers that are based on the robot manipulators theory. Numerical simulations are carried out to evaluate the performance of the controllers.

The Impact of Coil Position and Number on Wireless System Performance for Electric Vehicle Recharging.

Recently, most transportation systems have used an integrated electrical machine in their traction scheme, resulting in a hybrid electrified vehicle. As a result, an energy source is required to provide the necessary electric power to this traction portion. However, this cannot be efficient without a reliable recharging method and a practical solution. This study discusses the wireless recharge solutions and tests the system's effectiveness under various external and internal conditions. Moreover, the Maxwell tool is used in this research to provide a complete examination of the coils' position, size, number, and magnetic flux evolution when the coils are translated. In addition, the mutual inductance for each of these positions is computed to determine the ideal conditions for employing the wireless recharge tool for every charging application. A thorough mathematical analysis is also presented, and the findings clearly demonstrate the relationship between the magnet flux and the various external conditions employed in this investigation.

Modeling and Piezoelectric Analysis of Nano Energy Harvesters.

The expedient way for the development of microelectromechanical systems (MEMS) based devices are based on two key steps. First, perform the simulation for the optimization of various parameters by using different simulation tools that lead to cost reduction. Second, develop the devices with accurate fabrication steps using optimized parameters. Here, authors have performed a piezoelectric analysis of an array of zinc oxide (ZnO) nanostructures that have been created on both sides of aluminum sheets. Various quantities like swerve, stress, strain, electric flux, energy distribution, and electric potential have been studied during the piezo analysis. Then actual controlled growth of ZnO nanorods (NRs) arrays was done on both sides of the etched aluminum rod at low-temperature using the chemical bath deposition (CBD) method for the development of a MEMS energy harvester. Micro creaks on the substrate acted as an alternative to the seed layer. The testing was performed by applying ambient range force on the nanostructure. It was found that the voltage range on topside was 0.59 to 0.62 mV, and the bottom side was 0.52 to 0.55 mV. These kinds of devices are useful in low power micro-devices, nanoelectromechanical systems, and smart wearable systems.

Analysis of Electric Motor Magnetic Core Loss under Axial Mechanical Stress.

The electrical machine core is subjected to mechanical stresses during manufacturing processes. These stresses include radial, circumferential and axial components that may have significant influence on the magnetic properties and it further leads to increase in iron loss and permeability in the stator core. In this research work, analysis of magnetic core iron loss under axial mechanical stress is investigated. The magnetic core is designed with Magnetic Flux Density (MF) ranging from 1.0 T to 1.5 T with estimated dimensions under various input voltages from 5 V to 85 V. Iron losses are predicted by the axial pressure created manually wherever required and is further applied to the designed magnetic core in the range of 5 MPa to 50 MPa. Finite element analysis is employed to estimate the magnetic core parameters and the magnetic core dimensions. A ring core is designed with the selected dimensions for the experimental evaluation. The analysis of iron loss at 50Hz frequency for non-oriented electrical steel of M400-50A is tested experimentally using the Epstein frame test and force-fit setup test. Experimental evaluation concludes that the magnetic core saturates when it reaches its knee point of the B-H curve of the chosen material and also reveals that the axial pressure has a high impact on the magnetic properties of the material.

Consistent and Efficient Modeling of the Nonlinear Properties of Ferroelectric Materials in Ceramic Capacitors for Frugal Electronic Implants.

In recent years, the development of implantable electronics has been driven by the motivation to expand their field of application. The main intention is to implement advanced functionalities while increasing the degree of miniaturization and maintaining reliability. The intrinsic nonlinear properties of the electronic components, to be used anyway, could be utilized to resolve this issue. To master the implementation of functionalities in implantable electronics using the nonlinear properties of its electronic components, simulation models are of utmost importance. In this paper, we present a simulation model that is optimized in terms of consistency, computing time and memory consumption. Three circuit topologies of nonlinear capacitors, including hysteresis losses, are investigated. An inductively coupled measurement setup was realized to validate the calculations. The best results were obtained using the Trapezoid method in ANSYS with a constant step size and a resolution of 500 k points and using the Adams method in Mathcad with a resolution of 50 k points. An inductive coupling factor between 7% and 10% leads to a significant improvement in consistency compared to lower coupling factors. Finally, our results indicate that the nonlinear properties of the voltage rectifier capacitor can be neglected since these do not significantly affect the simulation results.

Design of UAV Downwash Airflow Field Detection System Based on Strain Effect Principle.

Accurate measurement of the downwash flow field of plant protection unmanned aerial vehicles (UAVs) is essential for analyzing the spatial distribution of droplets. To realize on-line rapid detection of the downwash flow field of a multi-rotor UAV, a flexible polypropylene detection device based on the principle of full bridge strain effect was proposed. Its performance principle was based on the physical deformation caused by wind pressure. The Fluid Flow and Static Structural modules of ANSYS 16.0 finite element software were used to simulate one-way fluid-solid coupling interaction. The surface of the resistive strain gauge embedded in the flexible detecting structure responded well to wind speed variation, hence it was suitable for downwash airflow wind field detection. By solving the strain force on the surface of the flexible detection structure, the length and layout of the grating wire of the strain gauge on the surface of the flexible detection structure were optimized. Meanwhile at 4 m·s-1 wind speed, the output voltage at varied bridge flexible acquisition systems in the acquisition card was measured. Results indicated coefficient of variation of 3.67%, 1.63% and 1.5%, respectively, which proved the good data acquisition consistency of the system. Through calibration test, the regression equation for the relationship between output voltage and wind speed for three unique sensor signal measuring circuits was established. The determination coefficients R2 for single bridge, half bridge and full bridge circuits were 0.9885, 0.9866 and 0.9959, respectively. In conclusion, by applying the multi-rotor plant protection UAV test platform, the results indicated the maximum relative error of the wind speed at each sampling point of the system at 1.0 m altitude was below 5.61%. Simulated and measured value had an RMSE maximum error of 0.1246 m·s-1. Moreover, downwash airflow detection not only has high accuracy but also has high sensitivity. Thus, there is convenience and practicability in the plant protection offered by this approach. The rapid measurement of UAV wind field and the established two-dimensional wind field model can provide a basis for precise application of agricultural aviation.

Design and Fabrication of a High-Frequency Single-Directional Planar Underwater Ultrasound Transducer.

This paper describes the fabrication of 1-3 piezoelectric composites by using PZT5-A pure piezoelectric ceramics and the preparation of a high-frequency single-directional planar underwater ultrasound transducer by using the developed composites. First, three material models of the same size were designed and simulated by ANSYS finite element simulation software. Next, based on the simulation results, the 1-3 piezoelectric composites were developed. Finally, a high-frequency single-directional planar underwater ultrasound transducer was fabricated by encapsulating and gluing the 1-3 piezoelectric composites. The performance of the transducer was tested, and results showed that the device was characterized by single-mode operation in the working frequency band, a high transmitting voltage response, and single directivity.