RESUMO
Two previously undescribed compounds (1 and 2) were isolated from Clinopodium polycephalum, a medicinal plant distributed in southwestern and eastern China. Their structures were elucidated using MS analyses and extensive 2D-homo and heteronuclear NMR data interpretations. Both compounds 1 and 2 could significantly shorten APTT and PT, and their procoagulant effect was comparable to that of positive drugs. At the same time, compound 2 had certain antioxidant activity (IC50 value of 2.25±0.05â µM in ABTS assay).
Assuntos
Lamiaceae , Plantas Medicinais , Anticoagulantes/farmacologia , Lamiaceae/química , Antioxidantes/farmacologia , Antioxidantes/química , China , Extratos Vegetais/farmacologia , Extratos Vegetais/química , Estrutura MolecularRESUMO
Two new triterpene saponins, clinopodiside VI (1) and saikosaponin c (2), along with six known saikosaponins (3-8), were isolated from the plant of Clinopodium polycephalum. Compounds 1-3 showed moderate inhibition against H9c2 cell damage induced by H2O2.
Assuntos
Cardiotônicos/isolamento & purificação , Cardiotônicos/farmacologia , Medicamentos de Ervas Chinesas/isolamento & purificação , Medicamentos de Ervas Chinesas/farmacologia , Lamiaceae/química , Ácido Oleanólico/isolamento & purificação , Ácido Oleanólico/farmacologia , Triterpenos/isolamento & purificação , Triterpenos/farmacologia , Cardiotônicos/química , Medicamentos de Ervas Chinesas/química , Peróxido de Hidrogênio/farmacologia , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Ácido Oleanólico/análogos & derivados , Ácido Oleanólico/química , Saponinas/farmacologia , Triterpenos/químicaRESUMO
Two previously undescribed diterpenes (1 and 2), as well as one curious triterpenoid were isolated from Clinopodium polycephalum, a medicinal plant distributed in southwestern and eastern China. Their structures were elucidated using MS analyses, UV spectrum, and extensive 2D-homo and heteronuclear NMR data interpretations. Among them, 1 had an unusual skeletal characteristic produced by a rare methyl migration pathway. All monomer compounds exhibited inhibitory effects on NO production in LPS-induced RAW 264.7 cells without affecting cell viabilities, which were comparable to that of positive control.