A guide to naming human non-coding RNA genes.

Research on non-coding RNA (ncRNA) is a rapidly expanding field. Providing an official gene symbol and name to ncRNA genes brings order to otherwise potential chaos as it allows unambiguous communication about each gene. The HUGO Gene Nomenclature Committee (HGNC, www.genenames.org) is the only group with the authority to approve symbols for human genes. The HGNC works with specialist advisors for different classes of ncRNA to ensure that ncRNA nomenclature is accurate and informative, where possible. Here, we review each major class of ncRNA that is currently annotated in the human genome and describe how each class is assigned a standardised nomenclature.

Preschool children generate quantity inferences from both words and pictures.

As children learn to communicate with others, they must develop an understanding of the principles that underlie human communication. Recent evidence suggests that adults expect communicative principles to govern all forms of communication, not just language, but evidence about children's ability to do so is sparse. This study investigated whether preschool children expect both pictures and words to adhere to the communicative principle of quantity using a simple matched paradigm. Children (N = 293) aged of 3 to 5 years (52.5% male and 47.5% female; majority White with college-educated mothers) participated. Results show that children as young as 3.5 years can use the communicative principle of quantity to infer meaning across verbal and pictorial alternatives.

Automatic mental simulation in native and non-native speakers.

Pictures of objects are verified faster when they match the implied orientation, shape, and color in a sentence-picture verification task, suggesting that people mentally simulate these features during language comprehension. Previous studies had an unintended correlation between match status and the required response, which may have influenced participants' responses by eliciting strategic use of this correlation. We removed this correlation by including color-matching filler trials and investigated if the color-match effect was still obtained. In both a native sample (Experiment 1) and a non-native sample (Experiment 2), we found strong evidence for a color-match advantage on median reaction time and error rates. Our results are consistent with the view that color is automatically simulated during language comprehension as predicted by the grounded cognition framework.

Confederate monuments and the history of lynching in the American South: An empirical examination.

The present work interrogates the history of Confederate memorializations by examining the relationship between these memorializations and lynching, an explicitly racist act of violence. We obtained and merged data on Confederate memorializations at the county level and lynching victims, also at the county level. We find that the number of lynching victims in a county is a positive and significant predictor of the number of Confederate memorializations in that county, even after controlling for relevant covariates. This finding provides concrete, quantitative, and historically and geographically situated evidence consistent with the position that Confederate memorializations reflect a racist history, one marred by intentions to terrorize and intimidate Black Americans in response to Black progress.

Guessability of Indian picture symbols for communication (IPSC) and picture communication symbols (PCS) among Malayalam-speaking typical adults.

The purpose of this study was to investigate the perceived symbol referent relationship for selected symbols in typical adults for two different symbol sets: Indian Picture Symbols for Communication (IPSC) and Picture Communication Symbols (PCS) to identify cultural influences on symbol recognition. A total of 240 typical adults, including 120 nonprofessionals, and 120 health professionals, from Kerala, a southern state in India, participated in the study. A guessability task involving IPSC and PCS symbols for 30 target referents was utilized. Guessability scores for each participant as well as each symbol stimuli across two symbol sets were determined. The guessability scores for IPSC were significantly (p <.001) higher than PCS. For both symbol sets, nouns were the most accurately guessed, followed by verbs, adjectives, and prepositions. The results also revealed that prompting and previous exposure to symbols tend to influence the transparency of symbols. Error analyses revealed that visual and conceptual cues within a symbol tend to influence guessability. The results indicate that cultural and linguistic factors play a role in symbol guessability. The study highlights the importance of investigating the iconicity of IPSC and PCS symbols across different populations within India, before using symbols for educational/clinical purposes.

Environmental factors contributing to using spelling in communication: Perceptions of literate aided communicators.

The aim of this interpretive qualitative study was to explore how environmental factors influence the transition from relying solely on graphic symbols to using spelling in face-to-face communicative interactions, from the perspective of literate adults with speech and motor impairments who use augmentative and alternative communication (AAC). Fourteen adults either chose to submit a written story with weekly email follow-up, took part in interviews conducted via Zoom1, or chose to communicate solely by email. Researchers analyzed data using Charmaz's (2014) constructivist grounded theory approach. The analysis yielded three themes explaining environmental factors relevant to the transition from using graphic symbols to spelling in communication: (a) access to AAC systems and services; (b) knowledgeable and supportive communication partners who have high expectations; and (c) opportunities to learn reading, writing, and spelling. Supportive factors included providing sufficient time for spelling in communicative interactions, structured learning opportunities for practice and independence, opportunities to learn through socially meaningful interactions and having print-rich and language-rich activity settings. Slow speed in navigating graphic symbols and lack of ability to express an exact message were motivational reasons for participants to use spelling in communicative interactions. The interaction among environmental factors and person-related characteristics warrants further investigation.

A misinterpreted psychoanalyst: Herbert Silberer and his theory of symbol-formation.

The primary aim of this article is to give a more detailed exposition of the cultural, personal, and theoretical contexts in which the Viennese psychoanalyst, Herbert Silberer's theories were born. When assessing the broader picture that this approach offers, it can be concluded that Silberer was an innovative thinker who inspired several of his contemporaries. Recognized in many respects by the society and scholars of this time, he represented quite a different viewpoint that was significantly influenced by several forms of Western esoteric thinking. Yet his main aim was to contribute to the field of psychoanalysis and develop a theory in which rationalistic psychoanalytic interpretations were combined with nonreductive approaches to mystical experiences. Silberer's name is frequently mentioned in a specific context in which his tragic suicide is emphasized rather than his innovations. Upon evaluating the materials recording Silberer's private life, it seems very likely that his suicide was not triggered by the criticism of Freud alone. Silberer's family affairs, his relationship with his father, and his financial and professional struggles could have all contributed to his tragic decision. This paper contends that Silberer's oeuvre deserves greater attention and must be evaluated based upon its own merit.

A standardised nomenclature for long non-coding RNAs.

The HUGO Gene Nomenclature Committee (HGNC) is the sole group with the authority to approve symbols for human genes, including long non-coding RNA (lncRNA) genes. Use of approved symbols ensures that publications and biomedical databases are easily searchable and reduces the risks of confusion that can be caused by using the same symbol to refer to different genes or using many different symbols for the same gene. Here, we describe how the HGNC names lncRNA genes and review the nomenclature of the seven lncRNA genes most mentioned in the scientific literature.

Young children interpret number gestures differently than nonsymbolic sets.

Researchers have long been interested in the origins of humans' understanding of symbolic number, focusing primarily on how children learn the meanings of number words (e.g., "one", "two", etc.). However, recent evidence indicates that children learn the meanings of number gestures before learning number words. In the present set of experiments, we ask whether children's early knowledge of number gestures resembles their knowledge of nonsymbolic number. In four experiments, we show that preschool children (n = 139 in total; age M = 4.14 years, SD = 0.71, range = 2.75-6.20) do not view number gestures in the same the way that they view nonsymbolic representations of quantity (i.e., arrays of shapes), which opens the door for the possibility that young children view number gestures as symbolic, as adults and older children do. A video abstract of this article can be viewed at https://youtu.be/WtVziFN1yuI HIGHLIGHTS: Children were more accurate when enumerating briefly-presented number gestures than arrays of shapes, with a shallower decline in accuracy as quantities increased. We replicated this finding with arrays of shapes that were organized into neat, dice-like configurations (compared to the random configurations used in Experiment 1). The advantage in enumerating briefly-presented number gestures was evident before children had learned the cardinal principle. When gestures were digitally altered to pit handshape configuration against number of fingers extended, children overwhelmingly based their responses on handshape configuration.

Mendel's terminology and notation reveal his understanding of genetics.

We describe both the terminology and use of symbols introduced by Mendel in his 1866 paper and discuss some misconceptions concerning their interpretation.

The Effects of Animation on the Guessability of Universal Healthcare Symbols for Middle-Aged and Older Adults.

OBJECTIVE: The purpose of this study was to investigate whether animation can help to improve the comprehension of universal healthcare symbols for middle-aged and older adults. BACKGROUND: The Hablamos Juntos (HJ) healthcare symbol system is a set of widely used universal healthcare symbols that were developed in the United States. Some studies indicated that HJ healthcare symbols are not well-understood by users in non-English-speaking areas. Other studies found that animations can improve users' comprehension of complex symbols. Thus, we wanted to test whether animation could help to improve users' comprehension of HJ symbols. METHODS: The participants included 40 middle-aged and 40 older adults in Taiwan. We redesigned the 12 HJ symbols into three visual formats-static, basic animation, and detailed animation-and compared them to find which best improved the participants' guessability scores. RESULTS: (1) Middle-aged adults' comprehension of static and basic animated symbols was significantly better than that of older adults, but there was no significant difference in the guessability scores between the two age groups in terms of detailed animated symbols; (2) In general, both basic animation and detailed animation significantly improved the guessability score, but the effect with detailed animation was significantly greater than that with basic animation; (3) Older women were more receptive to detailed animation and showed better guessing performance. CONCLUSION: Detailed animation contains more details and provides a more complete explanation of the concept of the static symbols, helping to improve the comprehension of HJ symbols for middle-aged and older adult users. APPLICATION: Our findings provide a reference for the possibility of new style symbol design in the digital and aging era, which can be applied to improve symbol comprehension.

The role of free-from symbols on consumer perceptions of healthiness, quality and intention to buy baked food products.

Little is known about the impact of "free-from" symbols on people's consumption choices - particularly for controversial ingredients such as palm oil. We investigated how "free-from" symbols influence consumers' perceptions of food products and whether the absence of an ingredient, whether real or fabricated, is seen as a sign of improved healthiness or quality. We conducted an experiment with a sample of 1215 adults representing the Italian population, showing them two products - crackers and sweet snacks - each with four different symbols. We created the "free-from CO2" and "free-from polyunsaturated fats" symbols, while "palm oil-free" and blank symbols were used for comparison. "free-from" symbols influence consumers' perceptions of the food as being of better quality and healthiness, regardless of the ingredient removed. This symbol also influenced purchasing intentions. Consumers' perceptions of the product were influenced by the "free-from" wording, rather than the type of ingredient or product presented.

A Concise Account of Information as Meaning Ascribed to Symbols and Its Association with Conscious Mind.

The term information is used in different meanings in different fields of study and daily life, causing misunderstanding and confusion. There is a need to clarify what information is and how it relates to knowledge. It is argued that information is meaning represented by physical symbols such as sights, sounds, and words. Knowledge is meaning that resides in a conscious mind. The basic building blocks of information are symbols and meaning, which cannot be reduced to one another. The symbols of information are the physical media of representation and the means of transmission of information. Without the associated meaning, the symbols of information have no significance since meaning is an ascribed and acquired quality and not an inherent property of the symbols. We can transmit symbols of information but cannot transmit meaning from one mind to another without a common protocol or convention. A concise and cohesive framework for information can be established on the common ground of the mind, meaning, and symbols trio. Using reasoned arguments, logical consistency, and conformity with common experiences and observations as the methodology, this paper offers valuable insights to facilitate clear understanding and unifies several definitions of information into one in a cohesive manner.

Self-Organisation of Prediction Models.

Living organisms are active open systems far from thermodynamic equilibrium. The ability to behave actively corresponds to dynamical metastability: minor but supercritical internal or external effects may trigger major substantial actions such as gross mechanical motion, dissipating internally accumulated energy reserves. Gaining a selective advantage from the beneficial use of activity requires a consistent combination of sensual perception, memorised experience, statistical or causal prediction models, and the resulting favourable decisions on actions. This information processing chain originated from mere physical interaction processes prior to life, here denoted as structural information exchange. From there, the self-organised transition to symbolic information processing marks the beginning of life, evolving through the novel purposivity of trial-and-error feedback and the accumulation of symbolic information. The emergence of symbols and prediction models can be described as a ritualisation transition, a symmetry-breaking kinetic phase transition of the second kind previously known from behavioural biology. The related new symmetry is the neutrally stable arbitrariness, conventionality, or code invariance of symbols with respect to their meaning. The meaning of such symbols is given by the structural effect they ultimately unleash, directly or indirectly, by deciding on which actions to take. The early genetic code represents the first symbols. The genetically inherited symbolic information is the first prediction model for activities sufficient for survival under the condition of environmental continuity, sometimes understood as the "final causality" property of the model.

Evaluating the potential implications of canadian front-of-pack labelling regulations in generic and branded food composition databases.

BACKGROUND: Canada proposed the implementation of mandatory front-of-pack (FOP) labelling regulations, whereby foods meeting or exceeding thresholds for nutrients-of-concern (i.e., total sugars, saturated fat, sodium) must display a 'high-in' FOP symbol (FOP). The objective of the study was to evaluate the potential implications of the proposed regulations using Canadian generic and branded food composition databases. METHODS: A generic food composition database of products consumed by Canadians, Canadian Nutrient File (CNF) 2015 (n = 3,677), and a branded food composition database of packaged foods and beverages, Food Label Information Program (FLIP) 2017 (n = 17,521), were used to evaluate the number and proportion of foods that would display a FOP symbol based on the details of the proposed FOP labelling regulations published in 2018. RESULTS: Overall, 35.5% (n = 1,306) of products in CNF 2015 and 63.9% (n = 11,193) of products in FLIP 2017 would display a FOP symbol for at least one nutrient-of-concern exceeding proposed thresholds. Soups, Combination Dishes, and Desserts categories in CNF 2015 and Combination dishes, Soups, and Meats categories in FLIP 2017 would have the highest proportion of products that would display a FOP symbol. Although displaying a FOP symbol for one nutrient was most common in both CNF 2015 (n = 992; 27.0%) and FLIP 2017 (n = 7,296, 41.6%), the number (i.e., 0-3) and type (i.e., saturated fat, sodium, total sugar) of nutrients displayed varied by food category. CONCLUSION: While the generic database, containing both packaged and unpackaged foods, revealed a low prevalence of foods that would display a FOP symbol, the branded database showed that the proposed FOP labelling regulations would identify over 60% of packaged foods with excess contents of nutrients-of-concern. Considering the high prevalence of packaged foods in Canada that would meet or exceed the thresholds of nutrients-of-concern, the proposed FOP labelling regulations should be implemented in a timely manner to help consumers easily identify foods high in nutrients-of-concern and encourage manufacturer-driven product reformulations.

Symbolic labeling in 5-month-old human infants.

Humans' ability to create and manipulate symbolic structures far exceeds that of other animals. We hypothesized that this ability rests on an early capacity to use arbitrary signs to represent any mental representation, even as abstract as an algebraic rule. In three experiments, we collected high-density EEG recordings while 150 5-month-old infants were presented with speech triplets characterized by their abstract syllabic structure-the location of syllable repetition-which predicted a following arbitrary label (e.g., ABA words were followed by a fish picture, AAB words by a lion). After a brief learning phase, EEG responses to novel words revealed that infants built expectations about the upcoming label based on the triplet structure and were surprised when it happened to be incongruent. Preverbal infants were thus able to recode the incoming triplets into abstract mental variables to which arbitrary labels were flexibly assigned. Importantly, infants also generalized to novel trials in which the pairing order was reversed (with the label preceding the auditory structure). Beyond conditioned associations, infants instantly inferred a bidirectional mapping between the abstract structures and the following label, a foundational operation for any symbolic system.

Expressive and receptive performance with graphic symbol sentences by individuals who use aided communication.

This study explored performance on expressive and receptive graphic symbol tasks and spoken comprehension by individuals who use augmentative and alternative communication (AAC) as well as the relationship of performance with participants' skills and characteristics. Participants were 19 children and youth (aged 5- to 18-years-old) who used aided communication. Four experimental tasks were administered, with either speech or symbols as input (stimuli) and symbols or choice from an array of pictures as output (response). Symbols were not accompanied by written or spoken labels in the tasks. Measures of receptive vocabulary, receptive syntax, memory, and visual cognitive skills as well as information regarding participant characteristics were collected. There were strong relationships among all experimental tasks. Cluster analysis revealed different response patterns that may suggest a progression in expressive and receptive performance with graphic symbol sentences. Individual differences in receptive language, particularly receptive syntax, were related to task performance. The findings suggest that different ways of experiencing symbols, in addition to spoken comprehension of the sentences and receptive spoken language more generally, may contribute to expressive graphic symbol sentences. Performance on receptive symbol tasks may uncover a level of facility with the graphic-symbol modality not observed through expressive symbol use in communicative situations.

The effect of non-verbal working memory on graphic symbol selection.

To identify the relationship between non-verbal working memory and graphic symbol selection, this study examined whether the response time to select target symbols in a sentence construction task differed between two groups: a high non-verbal working memory group and a low non-verbal working memory group. The interaction effect between non-verbal working memory skills and the degree of exposure to graphic symbols was also examined. Thirty-two non-disabled young adults participated in this study. Based on the quartile of the participants' scores on the non-verbal working memory task (i.e., the backward matrix task), data were selected from the sentence construction task completed by seven participants who belonged to the 25%ile and less and seven who belonged to the 75%ile and more; these data were used to examine group differences. A Mann-Whitney U test showed that non-verbal working memory skills had a significant effect on graphic symbol selection, as the high non-verbal working memory group combined three symbols faster than did the low memory group. No significant interaction effect was found between non-verbal working memory skills and the degree of exposure to symbols. The theoretical and clinical implications of the research findings are discussed.

Exploring adults' awareness of and suggestions for early childhood numerical activities.

This study focuses on adults who are neither preschool teachers nor professional caregivers and investigates their beliefs regarding the importance of engaging young children with numerical activities. It also examines the types of numerical activities adults report having observed children engaging with, as well as the types of activities they propose as a way for promoting counting, enumerating, recognizing number symbols, and number composition and decomposition. Findings showed that participants believed to a great extent that engaging young children with numerical activities is important. Most reported that they had observed children engaging with at least some numerical activity. In general, participants relayed more activities and more detailed activities when suggesting activities for each competency, than they did when reporting observed activities. Findings also suggested a need to enhance adults' knowledge regarding the necessity to promote verbal counting, separate from object counting, as well as to increase adults' awareness of number composition and decomposition. For mathematics educators wishing to plan workshops for adults, this study offers a method for investigating adults' knowledge of early numerical activities, as well as a starting point with which to plan appropriate workshops.

T-cell immunoglobulin and ITIM domain, as a potential immune checkpoint target for immunotherapy of colorectal cancer.

The importance of the tumor microenvironment in cancer progression has been well studied for many years. Immune checkpoint inhibitors (ICIs) are regarded as potential strategies in enhancing the immune responses in patients with cancer, particularly colorectal cancer (CRC). Notably, CRCs are extraordinarily heterogeneous and mostly are microsatellite-stable (MSS) or cold tumors, which means that the immune response is not usually as strong as that of foreign cells. T-cell immunoglobulin and ITIM domain (TIGIT) is a new immune checkpoint receptor overexpressed inside the CRC tumor-immune microenvironments. Moreover, several studies have shown that TIGIT in combination with other ICIs and/or conventional treatments, can lead to a robust anti-tumor response in CRC. This review looks deep inside TIGIT expression patterns, their various functions, and possible immunotherapy strategies to increase survival rates and decrease immune-related adverse events.