Evaluación preclínica de la actividad antiinflamatoria de un gel con aceite de árbol de té / Preclinical evaluation of the anti-inflammatory activity of a gel with tea tree oil

Objetivo: Evaluar la actividad antiinflamatoria de una formulación semisólida que contiene Aceite de Árbol de Té (AAT), a dos concentraciones (2 % y 2,5 %), para futuro tratamiento de enfermedad periodontal.Método: Prueba preclínica de edema auricular por aceite de crotón, con una muestra de 30 ratones, para ser com-parados con Indometacina y Diclofenaco.Resultados: La concentración al 2 % mostró un 51,21 % de inhibición de la actividad inflamatoria, mientras que para la concentración del 2,5 %, fue de 54,74 %. Las pruebas estadísticas para conocer la eficacia de los tratamien-tos demostraron que no existen diferencias significativas entre las combinaciones de tratamientos, indicando que todos tratamientos son similares (p>0,05).Conclusiones: Los resultados de este estudio demuestran que la forma semi solida de AAT, en los estudios preclíni-cos en la fase de ensayos in vivo con animales no humanos demostró poseer una actividad antiinflamatoria. (AU)

Objective: To evaluate the anti-inflammatory activity of a semi-solid Tea Tree Oil (TTO) form at 2 % and 2,5% con-centrations for treating periodontal disease.Method: A preclinical test in a sample of 30 mice with ear edema induced by croton oil was divided into two groups to compare treatment with Indomethacin and Diclofenac.Results: TTO at 2,5 % concentration showed a higher inhibition activity of inflammation (54,74 %) than TTO at 2 % (51,21 %). Statistical analysis showed no significative differences between treatment combinations (p>0,05).Conclusions: The tea tree oil in semi-solid form, applied in 2 - 2,5 % concentration in this preclinical study, showed consistent anti-inflammatory activity. (AU)

Curcuma longa: eficacia en el tratamiento de osteoatritis en adultos / Eficácia da cúrcuma no tratamento da osteoartrite em pacientes adultos / Effectiveness of turmeric in the treatment of osteoarthritis in adult patients

Introducción: La osteoartritis (OA) es una de las principales causas de dolor y discapacidad a nivel mundial. El tratamiento convencional son los analgésicos y antiinflamatorios no esteroideos (AINE), relacionados con efectos adversos gastrointestinales y cardiovasculares, motivo que hace necesaria la búsqueda de nuevas herramientas terapéuticas. Objetivo: Revisión de los últimos años de las diversas publicaciones científicas acerca de la eficacia de la cúrcuma (Curcuma longa) en el tratamiento de pacientes con osteoartritis. Métodos: Revisión sistemática a través de la búsqueda electrónica que incluyó PubMed, ProQuest, Google Scholar desde 9 de enero del2018 hasta 24 de mayo de 2021.Resultados: De los 81 artículos encontrados, se descartaron 70 porno cumplir con nuestros criterios, quedando 11 para la revisión sistemática. Conclusión: Los ensayos clínicos analizados muestran que el tratamiento con diferentes preparados de cúrcuma tiene eficacia similar a los AINEs, pero con menos efectos adversos, lo que lo sugiere como alternativa analgésica y antiinflamatoria. Sin embargo, las limitaciones metodológicas de los mismos hacen necesaria la realización de estudios más rigurosos antes de recomendarla como terapia eficaz para la osteoartritis de rodilla. (AU)

Introdução: A osteoartrite (OA) é uma das principais causas de dor e incapacidade em todo o mundo. O tratamento convencional recorre a analgésicos e antiinflamatórios não esteróides (AINEs), que estão relacionados com efeitos adversos gastrointestinais e cardiovasculares, o que tornanecessária a procura de novas estratégias terapêuticas. Objetivo: Rever as diversas publicações científicas dos últimos anos sobre a eficácia da cúrcuma (Curcuma longa) no tratamento de pacientes com osteoartrite. Métodos: Revisão sistemática através de pesquisa eletrónica que incluiu PubMed, ProQuest, Google Scholar de 9 de janeiro de 2018 a 24 de maio de 2021.Resultados: Dos 81 artigos encontrados, 70 foram descartados por não atenderem aos nossos critérios, restando 11para revisão sistemática. Conclusão: Os ensaios clínicos analisados mostram que otratamento com diferentes preparações de cúrcuma temeficácia semelhante aos AINEs, porém com menos efeitos adversos, o que o sugere como alternativa analgésica e anti-inflamatória. No entanto, suas limitações metodológicas tornam necessária uma realização de estudos mais rigorosos antes de a recomendar como uma terapia alternativa eficaz para a osteoartrite do joelho. (AU)

Introduction: Osteoarthritis (OA) is one of the main causes of pain and disability worldwide. The traditional treatment uses analgesic and non-steroidal anti-inflammatory drugs (NSAIDs), which are related to gastrointestinal and cardiovascular adverse effects, which makes necessary the search for new therapeutic tools. Objective: Review of the last years scientific publications about the efficacy of turmeric (Curcuma longa) in the treatment of patients with osteoarthritis. Methods: Systematic review through the electronic search in PubMed, ProQuest, Google Scholar from January 9, 2018 to May 24, 2021. Results: Out of the 81 articles found, 70 were discarded because did not meet our criteria, leaving 11 for systematic review. Conclusion: The clinical trials analyzed have shown that treatment with different turmeric preparations has similar efficacy to NSAIDs, but with less adverse effects, which suggests it as an analgesic and anti-inflammatory alternative. However, due to the methodological limitations of existing studies, more rigorous trials are needed beforere commending it as an effective therapy for knee osteoarthritis. (AU)

A influência do acompanhamento farmacoterapêutico na adesão à terapia com Morosil / La influencia del seguimiento farmacoterapéutico sobre la adherencia a la terapia con Morosil / The influence of pharmacotherapeutic follow-up on adherence to Morosil therapy

Após proibição de substâncias utilizadas no emagrecimento, pela ANVISA, notou-se uma crescente procura pelo Morosil. Objetivou realizar o acompanhamento farmacoterapêutico a usuários de Morosil, inseridos em uma prática de atenção farmacêutica, quanto a adesão terapêutica e satisfação do cliente. O procedimento foi realizado no período de maio a julho de 2017. Os dados foram coletados por meio dos questionários: Método Dáder de Acompanhamento Farmacoterapêutico, Morisky Medication Adherence Scale e Pharmacy Services Questionnaire, adaptados. A amostra foi constituída de 35 indivíduos: 97,1% feminino, 100% insatisfeitos com seu peso. Avaliados, 60% pré-obesos e 40% obesos. Observou-se condições de saúde associada, distúrbios endócrinos/hormonais (34,2%), psiquicos (22,8%) e cardiovasculares (14,2%), 96,8% fazem uso de polimedicação. A adesão terapêutica foi de 100% e 93,3% classificaram os cuidados farmacêuticos como ótimo. Não se constatou interação medicamentosa com Morosil. O acompanhamento farmacoterapêutico permitiu: manutenção dos objetivos terapêuticos, promoção da saúde do paciente e reconhecimento profissional do farmacêutico. (AU)

Después de la prohibición de determinadas sustancias utilizadas en la pérdida de peso por parte de ANVISA, hubo una creciente demanda de Morosil. Objetivo: realizar un seguimiento farmacoterapéutico a los usuarios de Morosil, insertados en una práctica asistencial farmacéutica, en cuanto a adherencia terapéutica y satisfacción del cliente. El estudio se realizó de mayo a julio de 2017. Los datos se recolectaron mediante cuestionarios: Método de seguimiento farmacoterapéutico de Dáder, Escala de adherencia a la medicación de Morisky y Cuestionario de servicios de farmacia, adaptado. La muestra estuvo conformada por 35 individuos: 97,1% mujeres, 100% insatisfechas con su peso. Un 60% de los participantes eran preobesos y un 40% obesos. Se observaron problemas de salud asociados, trastornos endocrinos/hormonales (34,2%), psiquiátricos (22,8%) y cardiovasculares (14,2%). El 96,8% estaban polimedicados. La adherencia terapéutica fue del 100% y 93,3% calificó la atención farmacéutica como excelente. No hubo interacción farmacológica con Morosil. El seguimiento farmacoterapéutico permitió el mantenimiento de los objetivos terapéuticos, la promoción de la salud del paciente y el reconocimiento profesional del farmacéutico. (AU)

After the ban on substances used in slimming, by ANVISA, there has been a growing demand for Morosil. This study aimed to carry out pharmacotherapeutic follow-up to Morosil users, inserted in a pharmaceutical care practice, regarding therapeutic adherence and customer satisfaction. The procedure was carried out from May to July 2017. The data were collected through the questionnaires: Dáder Method of Pharmacotherapeutic Follow-up Morisky Medication Adherence Scale and Pharmacy Services Questionnaire, adapted. The sample consisted of 35 individuals: 97.1% female, 100% dissatisfied with their weight. Evaluated, 60% as pre-obese and 40% as obese. Associated health conditions, endocrine / hormonal disorders (34.2%), psychic (22.8%) and cardiovascular (14.2%) were observed, 96.8% use polymedication. Therapeutic adherence was 100% and 93.3% rated pharmaceutical care as excellent. There was no drug interaction with Morosil. The pharmacotherapeutic follow-up allowed: maintenance of the therapeutic objectives, promotion of the patient's health and professional recognition of the pharmacist. (AU)

Fitoterapia para los síntomas del tracto urinario inferior en el varón: ¿qué ocurre después? Diez años de investigación / Phytotherapy for male luts: What happens then? 10-year research

Introducción y objetivos Nuestro objetivo es evaluar los resultados de la fitoterapia a largo plazo, centrándonos en el intervalo entre la fitoterapia y los tratamientos farmacológicos y los factores de riesgo que predisponen a dicho cambio en un seguimiento de 10 años. Material y métodos Se revisaron retrospectivamente los datos de los pacientes varones que tomaban fitoterapia para los síntomas del tracto urinario inferior (STUI) de leves a moderados entre enero y diciembre de 2010, a partir de una base de datos mantenida prospectivamente. Se realizó un seguimiento de los pacientes durante 10 años mediante consultas médicas presenciales y telefónicas. Resultados Ciento dos pacientes se sometieron al menos a un ciclo de fitoterapia para los STUI. Veinte (19,6%) pacientes resolvieron sus síntomas tras un ciclo fitoterápico y abandonaron el tratamiento, 27 (26,4%) continuaron con la fitoterapia y 52 (51%) cambiaron a bloqueadores alfa y/o inhibidores de la 5a-reductasa tras un intervalo medio de 24 meses. El motivo del cambio de tratamiento fue la sintomatología (n=45) o la progresión clínica (aumento del volumen residual n=15; retención urinaria, n=5). Los pacientes que cambiaron a fármacos sintéticos tenían una mediana de edad más alta (60 frente a 49), mayor volumen prostático (40 frente a 26cc) y antígeno prostático específico (1,9 frente a 0,9ng/ml), volumen residual más elevado (40 frente a 0cc) y una tasa de flujo máximo (Qmáx) más baja (12 frente a 15ml/s) en el momento de la presentación. Conclusiones El 46% de los pacientes con STUI leves o moderados sometidos a fitoterapia estarán libres de tratamiento o seguirán con la fitoterapia a los 10 años de la presentación de la enfermedad. Los pacientes de mayor edad, con próstatas más grandes, con volumen residual y antígeno protático específico más alto, deben ser informados sobre un mayor riesgo de progresión sintomática o clínica (AU)

Introduction and objectives Our objective is to assess the long-term results of phytotherapy, focusing on the interval between phytotherapy and pharmacological treatment and the predisposing risk factors to such switch on a 10-year follow-up. Material and methods The data of patients taking phytotherapy for mild to moderate male lower urinary tract symptoms (LUTS) from January to December 2010 were retrospectively reviewed from a prospectively maintained database. Patients were followed for 10 years through medical visits and telephone consultations. Results 102 patients underwent at least one cycle of phytotherapy for LUTS. Twenty (19.6%) patients resolved their symptoms after one phytotherapy cycle and stopped any treatment, 27 (26.4%) continued phytotherapy, and 52 (51%) switched to alpha-blockers and/or 5a-reductase inhibitors after a median interval of 24 months. The reasons for treatment switch were symptoms (n=45) or clinical progression (increased residual volume n=15; urinary retention, n=5). Patients switching to synthetic drugs had median higher age (60 vs 49), prostate volume (40 vs 26cc), prostate specific antigen (PSA) (1.9 vs 0.9ng/ml), residual volume (40 vs 0cc), and a lower maximum flow rate (Qmax) (12 vs 15ml/sec) at presentation. Conclusions 46% patients with mild to moderate LUTS undergoing phytotherapy will be either free of treatment or still on phytotherapy at 10 years from disease presentation. Older patients with larger prostates, increased residual volume and PSA, should be informed regarding their higher risk of symptomatic or clinical progression: the risk of a treatment switch to alpha-blockers or 5a-reductase inhibitors becomes an actual fact after an average span of 2 years (AU)

The patterns of herbal medicine use in the United Arab Emirates; A national study

Objectives: To examine the pattern, nature, and attitude towards herbal medicines usage in the UAE. Methods: A cross-sectional national questionnaire was distributed over five weeks in 7 emirates of UAE: The questioner was constructed using an online platform and delivered randomly to 448 adults in the UAE. The data collection technique adopted for this study was a convenient sampling. SPSS version 24 was used for statistical analysis. Results: Among participants, 98.7% used herbal medicines (HMs), and respondents who aged between 18 and 24 years were more likely to use HMs. Participant were mainly female (70.3%), with fair health status (55%), and participant with chronic disease were significantly less likely to use HM (10.9%). The majority of herbal medicine users believed herbal medicine were harmless, because they were derivatives of natural products. The findings of this study reported that many participants use HMs to enhance immunity (26.8%), and for relaxation (23.5%). Conclusion: Despites the risk of adverse-effects, many participants in this study are regular users for HMs and have perception that 89 may cure or prevent COVID-19. Therefore, awareness-raising campaigns that target HM users are essential to mitigate any unwanted consequences. (AU)

Arte de cuidar milenar: crenças e saberes de idosos sobre a fitoterapia / Arte milenario de cuidar: creencias y saberes de los adultos mayores sobre la fitoterapia / Millennial art of caring: beliefs and knowledge of the elderly about phytotherapy

Existe uma vasta gama de terapias conhecidas no mundo e uma das principais, que faz parte de diversas culturas no mundo percorrendo a história da humanidade, é a utilização das plantas e ervas medicinais com finalidade terapêutica. No Brasil, deduz-se que as práticas de fitoterapia estejam presentes desde antes da colonização, quando os indígenas faziam o uso curativo de acordo com seus conhecimentos e suas experiências [Fragmento de texto] (AU)

Mechanism of Rhizoma Coptidis in epilepsy with network pharmacology

Network pharmacology is a bioinformatics-based research strategy aimed at identifying drug actions and facilitating drug discovery. In this study, network pharmacology was used for exploring the anti-epileptic multi-target mechanism of Rhizoma Coptidis. The possible protein targets of Rhizoma Coptidis were predicted by constructing the pathway and network of drug targets. Then, the interaction of the main active components of Rhizoma Coptidis and predicted candidate targets were verified using molecular docking technology. Finally, nine active compounds were selected from Rhizoma Coptidis. A total of 68 targets associated with Rhizoma Coptidis treating epilepsy. The key targets were AKT1, IL6, VEGFA, and TP53. According to GO functional enrichment analysis, 289 items of biological process, 33 items of cellular component, and 55 items of molecular function were obtained. A total of 89 signaling pathways were identified through KEGG pathway enrichment analysis (P < 0.05), and HIF-1, TNF, and T-cell receptor signaling pathways were mainly related to epilepsy. Molecular docking showed quercetin and (R)-canadine combined well with the key targets. The active ingredient in Rhizoma Coptidis can regulate various signaling pathways, and have therapeutic effects on epilepsy (AU)

Interés de los productos naturales y su aportación a la farmacología y la terapéutica / Interesse dos produtos naturais e sua contribuição para a farmacologia e a terapêutica / Interest of natural products and their contribution to pharmacology and therapeutics

Los organismos vivos y en particular las plantas han sido y continúan siendo una de las fuentes más importantes de obtención de compuestos de interés farmacéutico. Aunque las plantas medicinales constituyen el origen de la farmacología y la terapéutica, y muchos fármacos son de origen natural, hoy en día la mayoría de los principios activos empleados en terapéutica occidental consisten en moléculas aisladas sintetizadas por la industria farmacéutica. Sin embargo, la fitoterapia, entendida como el uso racional y científico de plantas medicinales o partes de ellas con finalidad terapéutica, continúa siendo una herramienta muy demandada por la población. Además, el empleo de plantas para la obtención de principios activos ha supuesto el descubrimiento de algunos de los fármacos más importantes hoy en día y que han producido un punto de inflexión en la terapéutica farmacológica; tal es el caso de los analgésicos opioides como la morfina, antitumorales como el paclitaxel o antidiabéticos como la metformina. La gran variabilidad de estructuras químicas presentes en la naturaleza y en las plantas usadas en medicina tradicional supone un éxito asegurado para contribuir en el futuro al desarrollo de medicamentos y otros productos con aplicaciones para las distintas áreas terapéuticas y mejorar la salud de la población. (AU)

Os organismos vivos e em particular as plantas foram e continuam a ser uma das fontes mais importantes de obtenção de compostos de interesse farmacêutico. Embora as plantas medicinais constituam a origem da farmacologia e da terapêutica, e muitos medicamentos sejam de origem natural, hoje a maioria dos princípios ativos usados na terapêutica ocidental consiste em moléculas isoladas sintetizadas pela indústria farmacêutica. No entanto, a fitoterapia, entendida como o uso racional e científico das plantas medicinais, ou de partes de plantas para fins terapêuticos, continua a ser actualmente uma opção muito procurada pela população. Além disso, o uso de plantas para obter moléculas bioativas levou à descoberta de alguns dos medicamentos mais usados e prescritos na terapêutica actual, que produziram um ponto de inflexão na terapêutica farmacológica; são exemplos os analgésicos opióides como a morfina, alguns fármacos antitumorais como o paclitaxel ou antidiabéticos como a metformina. A grande variabilidade de estruturas químicas presentes na natureza e nas plantas utilizadas na medicina tradicional é um sucesso garantido por contribuir no futuro para o desenvolvimento de medicamentos e outros produtos com aplicações em diferentes áreas terapêuticas e para melhorar a saúde da população. (AU)

Living organisms and in particular plants have been and continue to be one of the most important sources of compounds of pharmaceutical interest. Although medicinal plants constitute the origin of pharmacology and therapeutics, and many drugs are of natural origin, today most of the active principles used in Western therapeutics consist of isolated molecules synthesized by the pharmaceutical industry. However, phytotherapy, understood as the rational and scientific use of medicinal plants or parts of them for therapeutic purposes, continues to be a tool in high demand by the population. Furthermore, the use of plants in order to obtain bioactive molecules has led to the discovery of some of the most widely used and prescribed drugs, which has been a turning point in therapeutics; such is the case of opioid analgesics such as morphine, antitumour drugs as paclitaxel or anti-diabetics such as metformin. The great variability of chemical structures presents in nature and in plants used in traditional medicine is an assured success to contribute in the future to the development of medicines and other products with applications for different therapeutic areas and to improve the health of the population. (AU)

Acute renal failure due to henna stone ingestion as a remedy of diabetes / Fallo renal agudo debido a la ingestión de cálculos de henna en el tratamiento de la diabetes

No disponible

Indicación farmacéutica en gripe y resfriado en el contexto del COVID-19 / Pharmaceutical indication for influenza and common cold in the context ofCOVID-19

Gripe y resfriado son enfermedades muy prevalentes, de consulta frecuente en la farmacia. Sus síntomas pueden confundirse y es importante la formación del farmacéutico para realizar una indicación adecuada. Estose agrava en la situación actual en la que, desde el inicio de la pandemia global por SARS-CoV-2, el número de consultas que se reciben en las farmacias comunitarias sobre temas relacionados con la COVID-19 es enorme. Al tener sintomatología similar, se hace aún más necesario conocer y realizar una buena diferenciación de dichas patologías. El objetivo de este trabajo es realizar una revisión actualizada de la bibliografía con la finalidad de orientar, de una manera práctica, a los farmacéuticos comunitarios en la toma de decisiones para una indicación farmacéutica óptima. Ante una consulta en la farmacia sobre gripe, resfriado o COVID-19, el farmacéutico, tras analizar los síntomas, debe hacer una evaluación diferencial y determinar si el problema de salud requiere de derivación médica o si, por el contrario, es un proceso autolimitado y se responsabiliza de la selección de un medicamento que no necesita receta médica, con el objetivo de aliviar los síntomas que ocasionan el problema de salud a instancias del paciente. Existen multitud de principios activos y sustancias vegetales indicados para aliviar los síntomas del resfriado y la gripe que forman parte, asimismo, de diferentes preparados galénicos. La indicación adecuada dependerá de los síntomas manifestados, de la edad y de la posible interacción con otra medicación ya establecida en el paciente.(AU)

Flu and colds are prevalent diseases, frequently consulted in the pharmacy. Their symptoms can be confounded and the training of the pharmacist is important to make an appropriate indication. This is more so in the current situation where, since the start of the global SARS-CoV-2 pandemic, the number of inquiries received at community pharmacies on COVID-19 related issues has been weighty. Now it is more necessary than ever to know and make a good differentiation of these pathologies and their symptoms.Theobjective of this work is to carry out an updated review of the bibliography in order to guide, in a practical way, community pharmacists in making decisions for an optimal pharmaceutical indication. Before a consultation in the pharmacy about flu, cold or COVID-19, the pharmacist, after analyzing the symptoms, must make a differential evaluation and determine if the health problem requires medical referral or if, on the contrary, it is a self-limited process and is responsible for the selection of a drug that does not need a prescription, with the aim of alleviating the symptoms that cause the health problem at the request of the patient.There are a multitude of active principles and plant substances indicated to alleviate the symptoms of cold and flu that are also part of different galenic preparations. The appropriate indication will depend on the symptoms manifested, the age and the possible interaction with another medication already established in the patient.(AU)

Herbal medicines for women and children's health in Tipang Village, District Humbang Hasundutan, North Sumatera

Objective: This study aimed to describe the use of medicinal plants for the health of mothers and children and to describe the local knowledge in traditional medicine to cure diseases that are often experienced by mothers and children in Tipang village, Humbang Hasundutan Regency, North Sumatra Province. Method: This study used a qualitative method with an interactive model. The scientific approach used in this research is local wisdom. Result: The local knowledge of the Tipang community is based on local wisdom on the use of herbs in traditional medicine. Besides the local knowledge about the types of medicinal plants, they also know how to apply it to therapy, especially massage therapy. Specifically, they use this traditional medicine for the health of mothers and children, including the use of bangun-bangun leaves to increase milk production, pultak-pultak (Physalis angulata), Bulung ni untejau (guava leaves), hunik (Curcuma domestica), botik (Carica papaya), harambir (Cocos nucifera) used to treat colic, ginger are used to reduce fever in children, paet-paet leaves are used to heal wounds, and halas (Alpinia galanga), and Napuran (Betel leaf) are used to treat the itching. Conclusion: Traditional medicine is part of the cultural system of the people of Tipang Village which has enormous potential benefits in building public health, particularly maternal and child health. (AU)

Dermatitis alérgica de contacto por aceite de árbol del té / Allergic Contact Dermatitis Due to Tea Tree Oil

No disponible

El tratamiento de las verrugas con guarumbo por los zapotecos / Guarumbo (Cecropia obtusifolia) for Warts in Zapotec Medicine

No disponible

Influencia del ajo en la hipertensión arterial / Influence of garlic on hypertension

No disponible

Valoración de las monografías de ESCOP por los usuarios de Sefit.es / Assessment of ESCOP monographs by Sefit.es users / Avaliação das monografias ESCOP pelos usuários do Sefit.es

La fitoterapia basada en la evidencia se fundamenta en la adecuada seguridad, calidad y eficacia de los productos fitoterápicos. Para poder prescribir, dispensar o recomendar fitoterapia con garantía, es necesario disponer de acceso a fuentes de información adecuadas, y las monografías de la European Scientific Cooperative on Phytothe-rapy (ESCOP) son en la actualidad el referente informativo para los profesionales. Para evaluar la consideración de estas monografías por parte de los profesionales de la salud, se realizó durante un año una encuesta a través de la página web de la Sociedad Española de Fitoterapia (SE-FIT). Se obtuvieron 232 respuestas, procedentes mayoritariamente de farmacéuticos y médicos del sector de actividad asistencial. La valoración media fue muy elevada, tanto en lo que respecta a la percepción de utilidad de las monografías (8,92 sobre 10), como a la adecuación de estas a sus necesidades profesionales (8,28). Los apartados que despiertan mayor interés son los aspectos clínicos y acciones farmacológicas y en menor grado los de definición y constituyentes y referencias bibliográficas. Los encuestados consideran que la extensión de las monografías es adecuada. Las monografías de ESCOP son consideradas una excelente herramienta para la prescripción, dispensación y recomendación de fitoterapia, así como en las tareas de formación, siendo consultada como fuente de información de referencia por parte de las empresas del sector

The evidence-based phytotherapy is based on the suitable safety, quality and efficacy of herbal products. In order to prescribe, dispense or recommend phytotherapy with guarantee, it is necessary to have access to appropriate sources of information, and the monographs of the European Scientific Cooperative on Phytotherapy (ESCOP) are currently the reference source for professionals.To assess the consideration of these monographs by health professionals, a survey was carried out over one year through the website of the Spanish Society of Phytotherapy (SEFIT). Two hundred thirty-two responses were obtained, mostly from pharmacists and medical doctors working in the healthcare sector of activity. The average rating was very high, both in terms of the perceived usefulness of the monographs (8.92 out of 10), as well as the suitability of these to their professional needs (8.28). The monograph sections that arouse most interest are the clinical aspects and the pharmacological actions and, to a lesser extent, those of definition and constituents and bibliographic references. Respondents believe that the extent of the monographs is appropriate. ESCOP monographs are considered an excellent tool for prescribing, dispensing and recommending phytotherapy, as well as for education, being used, in addition, as a referential information source by companies in the sector

A fitoterapia baseada em evidências está fundamentada na adequada segurança, qualidade e eficácia dos produtos fitoterápicos. Para poder prescrever, dispensar ou recomendar fitoterapia com garantia, é necessário ter acesso a fontes de informação adequadas, e as monografias da European Scientific Cooperative on Phytotherapy (ESCOP) são a referência informativa atual para os profissionais. Para avaliar a satisfação dessas monografias para os profissionais, foi realizado um inquérito durante um ano na página de internet da Sociedade Espanhola de Fitoterapia (SEFIT). Foram obtidas 232 respostas, principalmente de farmacêuticos e médicos do setor de saúde familiar. A avaliação média foi muito alta, tanto no que respeita à percepção da utilidade das monografias (8,92 em 10), como na adequação das mesmas às suas necessidades profissionais (8,28). As seções que despertam maior interesse são os aspectos clínicos e ações farmacológicas e, em menor grau, as referentes à definição e constituintes e referências bibliográficas. Os entrevistados consideram que a extensão das monografias é adequada. As monografias ESCOP são consideradas uma excelente ferramenta para a prescrição, dispensa e recomendação de fitoterapia, bem como na formação, sendo consultadas como fonte de informações de referência pelas empresas do setor

Recomendaciones dietéticas actualizadas en la prevención de la Migraña. Revisión / Dietary recommendations updated on the prevention of migraine headaches. Review

La dieta juega un papel clave en el desarrollo de la migraña, pero hay escasez en guías que orienten a profesionales en la prevención de la patología con dietoterapia. Los nutrientes implicados en el transcurso de la migraña y que pueden desencadenar un ataque agudo son muy diversos. Niveles bajos de vitamina D pueden facilitar ataques de migraña. La ingesta de folatos y vitamina B12 reducen la frecuencia y la gravedad de los ataques de migraña. Un déficit de cobre, zinc y magnesio se ha asociado también con un aumento de los episodios de migraña. Un aumento en sangre de hierro, manganeso, plomo y cadmio pueden propiciar ataques de migraña. Existe una relación entre la disminución en el consumo de aminas biógenas y pacientes con migraña. También se ha relacionado la migraña tanto con una dieta alta en grasas o cetogénica como también con una dieta baja en grasas. Además, un consumo de alimentos que propician la liberación de Inmunoglobulinas G y su relación con la inflamación aumentan el número de ataques de migraña. El propósito de esta revisión es ofrecer recomendaciones dietéticas sobre nutrientes clave para prevenir los brotes de migraña o minimizarlos

Diet plays a key role in development of migraine, but there is not enough guidelines to guide professionals in the prevention of pathology with diet therapy. The nutrients involved in the course of migraine and that can trigger an acute attack are very diverse. Low levels of vitamin D can cause neuronal sensitization and facilitate migraine attacks. Intake of folate supplements and vitamin B12 reduces homocysteine levels and, consequently, the frequency and severity of migraine attacks. A deficit of copper, zinc and magnesium has also been seen with an increase in migraine episodes. An increase in blood above the normal iron, manganese, lead and cadmium can cause migraine attacks. There is a relationship between the decrease in the biogenic substances and patients with migraine. It has also been related to migration with a high-fat or ketogenic diet as well as a low-fat diet because the type of fat ingested can be decisive. In addition, to food intake that promotes the release of Immunoglobulins. Its relation to reduction increases the number of migraine attacks. The purpose of this review is to offer dietary recommendations on key nutrients to prevent or minimize migraine outbreaks