RESUMO
The prevalence of HTLV-1 antibodies was evaluated in Jamaica among persons with various malignant, infectious, autoimmune and hematologic disorders and in clinically normal persons. Results document that: (1) the prevalence of HTLV-I antibodies in this population increases with age; (2) overall, there is no significant difference in the antibody prevalence between females and males: (3) antibody-positive individuals are born in all major regions of the island and geographical variance in antibody prevalence by place of birth was not prominent; (4) there is further confirmation of the high prevalence of HTLV-I antibody-positive lymphomas in Jamaica; and (5) the prevalence of HTLV-I antibodies in hemophiliacs, patients with chronic lymphocytic leukemia (CLL0, myelogenous leukemias, and patients with breast cancer is higher than in age-matched populations without malignancies, although none of these differences were statistically significant. The increased prevelence in hemophiliacs is most likely related to their frequent transfusion with blood products, but it has not yet been determined whether the prevalence in patients with other diseases is related to their disease or other as yet undefined factors in common. (Au)
Assuntos
Adulto , Humanos , Adolescente , Idoso , Feminino , Pessoa de Meia-Idade , Masculino , Leucemia-Linfoma de Células T do Adulto , Anticorpos Anti-HTLV-I , Fatores Etários , Fatores Sexuais , Hemofilia A/diagnóstico , Leucemia Linfoide/diagnóstico , Leucemia Mieloide/diagnóstico , Neoplasias , Neoplasias da Mama , Jamaica/epidemiologiaRESUMO
A case is described of a middle-aged negro woman with acute myeloid leukemia associated with a raised level of alkali resistant haemoglobin (A.R.Hb.). Family studies were negative and the increases in A.R.Hb. appears to have resulted from a disturbance in haemoglobin synthesis related in some way to the leukemic process. Previously reported associations of this type are reviewed (AU)
Assuntos
Humanos , Adulto , Feminino , Leucemia Mieloide/complicações , Hemoglobinas Anormais , EritropoeseRESUMO
Information from all parts of the world indicates that the incidence of leukaemia has been increasing in recent years. In a survey of leukaemia in Jamaica for the years 1953-1957, evidence is brought forward to suggest that a similar increase is occurring here and the figures for 1957 show an incidence of leukaemia comparable to that of most European countries. An analysis of 70 cases of leukaemia show chronic myeloid leukaemia to be the commonest variety. The frequency of the acute leukaemias is similar to British figures, and the overall picture of age and sex distribution is also almost identical. The possible reasons for this general increase in leukaemia are discussed. (AU)
