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1.
Am J Med Genet ; 61(1): 37-41, Jan. 1996.
Artigo em Inglês | MedCarib | ID: med-2996

RESUMO

A possible causal association between infective dematitis and HTLV-I infection was reported familial infective dematitis (ID) occurring in a 26-year-old mother and her 9-year-old son. The mother was first diagnosed with ID in 1969 at the age of 2 years in the Dermatology Unit at the University Hospital of the West indies (U.H.W.I.) in Jamaica. The elder of her 2 sons was diagnosed with ID at the age of 3 years, also at U.H.W.I. Both mother and son are HTLV-I-seropositive. A second, younger son, currently age 2 years, is also HTLV-I-seropositive, but without clinical evidence of ID. Major hitocompatibility complex (MHC), class II, human leucocyte antigen (HLA) genotyping documented a shared class II haplotype, DRB*DQBI* (1101-0301), in the mother and her 2 sons. This same haplotype has been described among Japanese patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and has been associated with a possible pathologically heightened immune repsonse to HTLV-I infection. The presence of this haplotype in these familial ID cases with clinical signs of HAM/TSP may have contributed to their risk for development of HAM/TSP. The unaffected, HTLV-I seropositive younger son requires close clinical follow-up. (AU)


Assuntos
Humanos , Masculino , Feminino , Criança , Pré-Escolar , Adulto , Relatos de Casos , Dermatite/etiologia , Antígenos HLA-DQ , Antígenos HLA-DR/genética , Infecções por HTLV-I/imunologia , Paraparesia Espástica Tropical/imunologia , Dermatopatias Infecciosas/etiologia , Genótipo , Haplótipos , Teste de Histocompatibilidade , Jamaica , Linhagem , Valor Preditivo dos Testes , Dermatite/genética , Dermatite/imunologia , Infecções por HTLV-I/complicações , Infecções por HTLV-I/genética , Paraparesia Espástica Tropical/imunologia
2.
South Med J ; 85(9): 904-6, Sept. 1992.
Artigo em Inglês | MedCarib | ID: med-7254

RESUMO

We determined HLA-antigen frequencies and corresponding relative risks (RR) in 30 Jamaicans with myasthenia gravis (MG) and 40 normal controls.. using a microcytotoxicity assay and commercially prepared typing trays, we found that the strongest HLA associations with MG in Jamaicans were with HLA-A2 (RR = 6.15), HLA-B8 (RR = 3.4), HLA-B13 (RR=7.6), and DQw4 (RR = 3.8). After correction of the P value for the number of antigens tested, only HLA-A2 was stastistically significantly increased in MG patients. There was a statistically significant negative association between Mg and HLA-DR2, as well as as HLA-A9 and -B5. No correlation was observed between HLA phenotype, thymic disease, clinical grades, or disease course. HLA-A2 and sex were independent risk factors for MG, female patients having a higher risk (RR = 5.8). Further studies using larger patient and control groups, locally derived typing sera, and DNA probe analysis are indicated. (AU)


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Frequência do Gene , Antígenos HLA/genética , Miastenia Gravis/genética , Testes Imunológicos de Citotoxicidade , Etnicidade/genética , Teste de Histocompatibilidade , Hospitais Universitários , Antígeno HLA-A2/genética , Jamaica/epidemiologia
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