RESUMO
Jamaican neuropathy (JN) is a common disorder in Jamaica and has characteristics similar to neurological diseases found in other tropical areas. JN is a clinical syndrome and occurs in two forms: spastic and ataxic. This is the first known electrophysiological study of this disease. In the spastic group of JN, peripheral electrophysiological findings were mostly normal, suggesting a central cause for their symptoms. The only patient with the ataxic form of JN had a chronic axonal peripheral neuropathy. (AU)
Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Doenças do Sistema Nervoso/fisiopatologia , Paraparesia Espástica Tropical/fisiopatologia , Potenciais de Ação , Ataxia/etiologia , Ataxia/fisiopatologia , Eletromiografia , Jamaica , Neurônios Motores/fisiologia , Espasticidade Muscular/etiologia , Espasticidade Muscular/fisiopatologia , Doenças do Sistema Nervoso/classificação , Doenças do Sistema Nervoso/complicações , Condução Nervosa , Neurônios Aferentes/fisiologiaRESUMO
A method is decribed for the direct measurement of changes in luminal diameter at all levels of the airway. Using this method it was found that (i) abrupt bronchiolar collapse occurred in the preterminal and terminal bronchioles once the luminal diameter was reduced to a critical level: (ii) decreased temperatures resulted in airway narrowing which was reversed by increasing the temperature to above 25 degrees C; as a rule, airway narrowing followed a cranial to caudal direction, and higher concentration of a drug being required to close the peripheral airways; (iii) bronchodilators except Carbuterol had no effect on resting bronchial tone or on acetylcholine-induced constriction in the absence of O-adrenoreceptor blockade; (iv) at 35 degrees C rhythmic waves (frequency 6--20/min) were observed; these waves travelled from the periphery in a cranial direction. (AU)
