Resumo
It aimed to investigate the possible effects of the oral administration of the latex diluted of H. sucuuba(LdHs) on pregnancy in the female Swiss mice and evaluation of progeny. We used 54 female mice pregnantwomen in the evaluation protocol gestational toxicity and progeny. Females received the LdHs by gavage during8th to 12th day of gestation and during late pregnancy were euthanized for the observation of gestationalparameters and evaluation of the fetuses. None of LdHs doses interfered negatively on gestational parametersinvestigated or ossification of fetuses, and also did not cause visceral malformations in the offspring. Therefore, thetested doses of LdHs did not cause gestational toxicity in female mice as well as did not interfere in the progeny.
Assuntos
Feminino , Animais , Camundongos , Apocynaceae/toxicidade , Camundongos/anatomia & histologia , Camundongos/fisiologiaResumo
It aimed to investigate the possible effects induced by the diluted latex oral administration of H. sucuuba(LdHs) in Wistar rats on the estrous cycle and other organ systems. The Wistar rats received by gavage the LdHs.The results showed that there was a decrease in average daily intake and ponderable development negativeinterference in the group treated with the dose 100 mg / kg. The number of primary follicles and in the dose 100 mg/ kg LdHs was superior to the control group. It was also observed a decrease in the number of estrous cycles andan increase in the average duration of the estrous cycle in this group. Therefore, doses 25 and 50 mg / kg of LdHshave been shown safe, however the dose 100 mg / kg decreased reproductive efficiency and promoted a lowsystemic toxicity as caused a decrease in feed consumption and interfered with the ponderable development.
Assuntos
Feminino , Animais , Ratos , Apocynaceae/fisiologia , Apocynaceae/química , Apocynaceae/toxicidade , Ciclo Estral/fisiologia , Ratos Wistar/fisiologiaResumo
It aimed to investigate the possible effects induced by the diluted latex oral administration of H. sucuuba(LdHs) in Wistar rats on the estrous cycle and other organ systems. The Wistar rats received by gavage the LdHs.The results showed that there was a decrease in average daily intake and ponderable development negativeinterference in the group treated with the dose 100 mg / kg. The number of primary follicles and in the dose 100 mg/ kg LdHs was superior to the control group. It was also observed a decrease in the number of estrous cycles andan increase in the average duration of the estrous cycle in this group. Therefore, doses 25 and 50 mg / kg of LdHshave been shown safe, however the dose 100 mg / kg decreased reproductive efficiency and promoted a lowsystemic toxicity as caused a decrease in feed consumption and interfered with the ponderable development.(AU)
Assuntos
Animais , Feminino , Ratos , Ciclo Estral/fisiologia , Apocynaceae/química , Apocynaceae/fisiologia , Apocynaceae/toxicidade , Ratos Wistar/fisiologiaResumo
It aimed to investigate the possible effects of the oral administration of the latex diluted of H. sucuuba(LdHs) on pregnancy in the female Swiss mice and evaluation of progeny. We used 54 female mice pregnantwomen in the evaluation protocol gestational toxicity and progeny. Females received the LdHs by gavage during8th to 12th day of gestation and during late pregnancy were euthanized for the observation of gestationalparameters and evaluation of the fetuses. None of LdHs doses interfered negatively on gestational parametersinvestigated or ossification of fetuses, and also did not cause visceral malformations in the offspring. Therefore, thetested doses of LdHs did not cause gestational toxicity in female mice as well as did not interfere in the progeny.(AU)