Detalhe da pesquisa
1.
In vivo CRISPR editing with no detectable genome-wide off-target mutations.
Nature
; 561(7723): 416-419, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30209390
2.
Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes.
Mol Ther
; 29(5): 1903-1917, 2021 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33484963
3.
High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets.
J Mol Cell Cardiol
; 127: 204-214, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30597148
4.
Orthologue chemical space and its influence on target prediction.
Bioinformatics
; 34(1): 72-79, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28961699
5.
BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B.
BMC Biol
; 16(1): 150, 2018 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30593278
6.
Targeted Metabolic Profiling of the Tg197 Mouse Model Reveals Itaconic Acid as a Marker of Rheumatoid Arthritis.
J Proteome Res
; 15(12): 4579-4590, 2016 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27704840
7.
In vivo phage display identifies novel peptides for cardiac targeting.
Sci Rep
; 14(1): 12177, 2024 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38806609
8.
Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner.
Nat Commun
; 15(1): 2358, 2024 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38509128
9.
Simultaneous inhibition of DNA-PK and PolÏ´ improves integration efficiency and precision of genome editing.
Nat Commun
; 14(1): 4761, 2023 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37580318
10.
A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo.
Nat Commun
; 14(1): 5474, 2023 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37673883
11.
Engineered Cas9 extracellular vesicles as a novel gene editing tool.
J Extracell Vesicles
; 11(5): e12225, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35585651
12.
Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing.
Nat Commun
; 13(1): 1240, 2022 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35332138
13.
Rapid target validation in a Cas9-inducible hiPSC derived kidney model.
Sci Rep
; 11(1): 16532, 2021 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34400685
14.
Universal toxin-based selection for precise genome engineering in human cells.
Nat Commun
; 12(1): 497, 2021 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33479216
15.
CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs.
Nat Commun
; 11(1): 4132, 2020 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32807781
16.
Delivering Robust Candidates to the Drug Pipeline through Computational Analysis of Arrayed CRISPR Screens.
SLAS Discov
; 25(6): 646-654, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32394775
17.
A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries.
SLAS Discov
; 25(6): 618-633, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32476557
18.
Systematic Evaluation of CRISPRa and CRISPRi Modalities Enables Development of a Multiplexed, Orthogonal Gene Activation and Repression System.
ACS Synth Biol
; 8(9): 1998-2006, 2019 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31398008
19.
Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt's lymphoma anti-tumor activity.
Oncotarget
; 8(41): 69219-69236, 2017 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29050199
20.
Understanding Cytotoxicity and Cytostaticity in a High-Throughput Screening Collection.
ACS Chem Biol
; 11(11): 3007-3023, 2016 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27571164