Detalhe da pesquisa
1.
Mitigating a Bioactivation Liability with an Azetidine-Based Inhibitor of Diacylglycerol Acyltransferase 2 (DGAT2) En Route to the Discovery of the Clinical Candidate Ervogastat.
Chem Res Toxicol
; 36(6): 934-946, 2023 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37148271
2.
Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).
Biochemistry
; 57(51): 6997-7010, 2018 12 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30422629
3.
Optimization of amide-based EP3 receptor antagonists.
Bioorg Med Chem Lett
; 26(11): 2670-5, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27107947
4.
Design and synthesis of aryl sulfonamide-based nonsteroidal mineralocorticoid receptor antagonists.
Bioorg Med Chem Lett
; 23(23): 6239-42, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24157365
5.
Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries.
Bioorg Med Chem Lett
; 23(5): 1407-11, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23337601
6.
From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.
Bioorg Med Chem Lett
; 23(1): 194-7, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23177788
7.
Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life.
ACS Med Chem Lett
; 14(10): 1427-1433, 2023 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37849537
8.
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
J Med Chem
; 65(22): 15000-15013, 2022 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36322383
9.
Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor.
Bioorg Med Chem Lett
; 21(5): 1306-9, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21310611
10.
Stereoselective construction of halogenated quaternary stereogenic centers via catalytic asymmetric Diels-Alder reaction.
J Am Chem Soc
; 132(16): 5625-7, 2010 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20373752
11.
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
J Med Chem
; 63(22): 13546-13560, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32910646
12.
Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs.
PLoS One
; 13(11): e0206279, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30427871
13.
Identification of Morpholino-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-ones as Nonsteroidal Mineralocorticoid Antagonists.
J Med Chem
; 61(3): 1086-1097, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29300474
14.
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.
J Med Chem
; 59(3): 1165-75, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26734723
15.
"Designer acids": combined acid catalysis for asymmetric synthesis.
Angew Chem Int Ed Engl
; 44(13): 1924-42, 2005 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15770618
16.
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).
Sci Rep
; 5: 17391, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26620127
17.
Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).
J Med Chem
; 58(18): 7173-85, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26349027
18.
Asymmetric protonation of lithium enolates of alpha-amino acid derivatives with alpha-amino acid-based chiral Brønsted acids.
Chem Commun (Camb)
; (5): 566-7, 2003 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12669827
19.
Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists.
ACS Med Chem Lett
; 4(1): 63-8, 2013 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900564
20.
Glucokinase activators.
Pharm Pat Anal
; 1(3): 301-11, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24236843