Detalhe da pesquisa
1.
Emerging Process Modeling Capabilities for Dry Powder Operations for Inhaled Formulations.
Mol Pharm
; 20(11): 5332-5344, 2023 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37783568
2.
Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors.
Bioorg Med Chem Lett
; 26(22): 5580-5590, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27769621
3.
The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors.
Bioorg Med Chem Lett
; 25(4): 847-55, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25599837
4.
In silico prediction of pharmaceutical degradation pathways: a benchmarking study.
Mol Pharm
; 11(11): 4179-88, 2014 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25364862
5.
Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 23(23): 6447-54, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24139583
6.
Trends in small molecule drug properties: A developability molecule assessment perspective.
Drug Discov Today
; 27(12): 103366, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36122862
7.
Novel cytochrome p450 bioactivation of a terminal phenyl acetylene group: formation of a one-carbon loss benzaldehyde and other oxidative products in the presence of N-acetyl cysteine or glutathione.
Chem Res Toxicol
; 24(5): 677-86, 2011 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21395287
8.
Clearance prediction for Amgen molecules against Extended Clearance Classification System (ECCS) and future directions.
Drug Discov Today
; 26(1): 10-16, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33075472
9.
Modulating target engagement of small molecules via drug delivery: approaches and applications in drug discovery and development.
Drug Discov Today
; 26(3): 713-723, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33333320
10.
Structural characterization and developability assessment of sustained release hydrogels for rapid implementation during preclinical studies.
Eur J Pharm Sci
; 158: 105689, 2021 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33359482
11.
The Evolving Druggability and Developability Space: Chemically Modified New Modalities and Emerging Small Molecules.
AAPS J
; 22(2): 21, 2020 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31900602
12.
A quantitative kinetic study of polysorbate autoxidation: the role of unsaturated fatty acid ester substituents.
Pharm Res
; 26(10): 2303-13, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19669100
13.
pH control of nucleophilic/electrophilic oxidation.
Int J Pharm
; 357(1-2): 180-8, 2008 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-18400425
14.
Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.
ACS Med Chem Lett
; 6(9): 987-92, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26396685
15.
Early prediction of pharmaceutical oxidation pathways by computational chemistry and forced degradation.
Pharm Res
; 21(9): 1708-17, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15497700