RESUMO
Thirty-three subjects entered a blind-observer, random, prospective study of three forms of conservative treatment of sports-induced Achilles tendinitis, results being assessed by clinical and biomechanical parameters. Two patient groups received heel pads, ultrasound, and exercises, while the third received only ultrasound and exercises. All three groups showed some improvement at both 10 day and 2 month assessment, but the claimed benefit of viscoelastic pads widely used by athletes was not substantiated. The more striking benefit from ultrasound and exercises alone occurred in patients with a shorter history; a comparison of duration of injury in all three groups suggested this was an important factor influencing outcome. The study has highlighted the need for biomechanical outcome measures as well as for more objective clinical outcome measures in the assessment of physical therapy.
Assuntos
Tendão do Calcâneo , Aparelhos Ortopédicos , Tendinopatia/terapia , Tendão do Calcâneo/fisiopatologia , Adolescente , Adulto , Criança , Método Duplo-Cego , Feminino , Marcha , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Distribuição Aleatória , Tendinopatia/fisiopatologiaRESUMO
Synthesis of trans-fused lactones containing the indane nucleus has resulted in a series of potent acylating inhibitors of thrombin. As an example compound 11e has an apparent second order rate constant of 11 x 10(6) M(-1)sec(-1) for the inhibition of thrombin. The anticoagulant activity of these compounds is discussed.
Assuntos
Antitrombinas/farmacologia , Indanos/química , Lactonas/farmacologia , Anticoagulantes/síntese química , Anticoagulantes/química , Anticoagulantes/farmacologia , Antitrombinas/síntese química , Antitrombinas/química , Humanos , Cinética , Lactonas/síntese química , Lactonas/química , Tempo de Tromboplastina ParcialRESUMO
Synthesis of a variety of 5,5-trans fused lactones, related to compounds found in extracts of Lantana camara, has provided a series of novel acylating inhibitors of human thrombin, trypsin, chymotrypsin and human leucocyte elastase. The most effective thrombin inhibitor is 7 with an IC50 of 130 nM and a Kobs/[1] of 4,000 M-1 s-1.
Assuntos
Lactonas/síntese química , Inibidores de Serina Proteinase/síntese química , Trombina/antagonistas & inibidores , Sítios de Ligação , Humanos , Cinética , Inibidores de Serina Proteinase/farmacologiaRESUMO
A series of trans-fused lactams containing the indane nucleus has been prepared. Compound 19 has much enhanced plasma stability compared with its lactone counterpart and shows appreciable in vitro anticoagulant activity.