ABSTRACT
Objective: To review the pathological characteristics of the lungs in mitral stenosis with pulmonary hypertension, and provide evidence for clinical treatment. Methods: Pulmonary pathological changes in 37 patients with rheumatic mitral stenosis and secondary pulmonary hypertension received mitral valve replacement. Six patients of aortic valve disease without pulmonary hypertension received aortic valve replacement and were taken as control. The lung biopsies were obtained from the middle lobe of the right lung in operation. Pulmonary muscular arteries were studied quantitatively and qualitatively. Results: All patients with mitral stenosis showed various degrees of vascular and other associated parenchymal changes. The structural changes in the muscular arteries was graded according to the degree of MT/R. There was 81% of patients with mitral stenosis in mild to moderate degree. Conclusion: The pulmonary vascular pathological changes of patients who have rheumatic mitral stenosis with pulmonary hypertension are related to the level of preoperative pulmonary artery pressure. And in most of them the pulmonary vascular pathological changes are in mild to moderate degree.
ABSTRACT
The relation between left atrial (LA) size and myocardial pathological changes, and clinical implications were studied in 25 patients with- rheumatic mitral stenosis. The results showed that LA size was significantly correlated with pathological severity of myocardium (P 100 ml/m2 and accompanied by moderate or severe pathological changes easily suffered from Af (P200ml/m2 and severe pathological changes. The results suggest that occurence of Af may be predicated based on the LA volume and Af cardioversion should be selectively performed to obtain better results.
ABSTRACT
In this study, image analysis technique (IAT) was used in the quantitative analysis of the essential pathological changes in the myocardium. The myocardial samples were taken from 46 patients of rheumatic heart disease, who had undergone valve replacement. Stepwise regression of the data demonstrated myocardial fibrosis and chronic arteriolopathy were remarkably correlated to the heart functions a Her the operation, especially myocardial fibrosis. Discriminants were obtained by stepwise discrimination analysis, and they may be used as predictors.
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This article reports 10 cases of malignant lymphoma of the breast including 7 of primary and 3 of secondary. According to the stardard of classification which was revised at the meeting in Chendu in 1985, there were 5 cases of cleaved-noncleaved cell lymphoma, 1 of cleaved, 2 of lympho - plasmacytic and 2 of noncleaved. Monoclonal antibody marker study was performed in 2 cases, and as a result, one was K positive and ? negative, but in another case, K and ? were all negative. A differential diagnosis was discussed between noncleaved lymphoma and medullary carcinoma, undifferentiated carcinoma and lympho-plasmcytic lymphoma, undifferentiated carcinoma and lymphoplasmcytic lymphoma, and cleaved cell lymphoma, malignant lymphoma and pseudolymphoma of the breast. We consider that multiple sourses of combined chemotherapy after operation and irradiation might improve the prognosis and increase the survival rate.
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The effect of high-dose glucocorticoid (GC) on plasma phospholipase A2 (PLA2) activity, extravascular lung water (EVLW) and lung pathology during cardiopulmonary bypass (CPB) was studied on the CPB model in rabbits. The results showed that both plasma PLA2 activities and EVLW increased significantly during CPB, and there was a significant correlation between EVLW and plasma PLA2 activities at 90 min of CPB (r = 0. 8439, P
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The distribution of copper-zinc superoxide dismutase (Cu-ZnSOD) in subcellular organelles in 8 cases of normal human myocardium was studied by using immunocytochemistry and immunoelectron microscopic technique and the contents of Cu-Zn SOD in myocardium were measured by radioimmunoassay. The results showed that Cu-ZnSOD was in most myocardial cells. The contents of Cu-ZnSOD in the ventricular myocardial cells were higher than those in the atrial myocardial cells. The Cu-ZnSOD labeled with immunogold particles were distributed throughout cytoplasm and nuclei, but less in mitochondria and a very little in lysosomes. No gold particle was found on the membranous structure of sarcoplasmic reticulum as well as Golgi complex. The results demonstrate that the myocardium was the tissue containing quite abundant Cu-Zn SOD.