ABSTRACT
Solitary fibrous tumour (SFT) is a rare spindle cell neoplasm arising at pleural and extrapleural sites. Five cases of SFT diagnosed at our institution over a five year period were reviewed. Haematoxylin and eosin stained histological sections, immuno-histochemical markers including CD34 and electron microscopy were the different methods used to study these tumours. Three histological features were consistently observed in all the tumours: the tumours were composed of short spindle cells separated by dense collagen bands and arranged in alternate hypocellular and hypercellular areas. CD34 positivity was seen in all the cases. SFT's have been reported to behave in an unpredictable fashion and hence prolonged follow up is essential. Histology, CD34 positivity and electron microscopy are useful tools in diagnosing SFT. While the pleural tumours can be diagnosed based on histology, this must be substantiated by ancillary techniques in case of extrapleural tumours.
Subject(s)
Adolescent , Adult , Antigens, CD34/metabolism , Female , Humans , Lung Neoplasms/diagnosis , Male , Mesoderm/pathology , Middle Aged , Neoplasms, Fibrous Tissue/diagnosis , Parotid Neoplasms/diagnosis , Pelvis/pathology , Peritoneal Cavity/pathology , Pleural Neoplasms/diagnosisABSTRACT
Sporadic sclerotic fibroma (SF) and solitary fibrous tumor (SFT) arising in the oral cavity are very rare. In this report, we describe two cases of oral pathology, one involving SF and the other involving SFT. Both cases presented with well- circumscribed, firm nodules with similar gross findings. However, the histologic findings of the SF and SFT showed rather distinct features. The SF was composed of hyalinized sclerotic collagen bundles arranged in a whorled pattern, whereas the SFT was formed by spindles cells arranged in hypo- and hypercellular areas. The immunohistochemical findings were similar in both cases; there was positivity for vimentin, CD34, and CD99, but bcl-2 positivity was only seen in the SFT. Although their histopathologies are similar, SF and SFT should be considered in the differential diagnosis of soft tissue tumors in the oral cavity.
Subject(s)
Adult , Female , Humans , Antigens, CD/analysis , Antigens, CD34/analysis , Cell Adhesion Molecules/analysis , Diagnosis, Differential , Fibroma/diagnosis , Immunohistochemistry , Mouth/chemistry , Mouth Neoplasms/diagnosis , Neoplasms, Fibrous Tissue/diagnosis , Proto-Oncogene Proteins c-bcl-2/analysis , Vimentin/analysisABSTRACT
Apresentamos um caso de tumor renal num paciente de 27 anos de idade, que foi submetido a estudo de imagem por tomografia computadorizada e ressonância magnética. As características radiológicas da massa induziam para um diagnóstico de tumor renal maligno de origem intraparanquimatosa. No entanto, o estudo histopatológico revelou tumor fibroso solitário benigno originário da pelve e porção calicial do rim direito.
Subject(s)
Humans , Male , Adult , Histiocytoma, Benign Fibrous , Mesothelioma , Mesothelioma/diagnosis , Kidney Neoplasms/diagnosis , Kidney Neoplasms/pathology , Kidney/pathology , Histiocytoma, Benign Fibrous , Magnetic Resonance Imaging , Neoplasms, Fibrous Tissue/diagnosis , Tomography, X-Ray ComputedABSTRACT
El tumor fibroso de la pleura es una neoplasia poco habitual cuya presentación clínica es inespecífica, obligando al diagnóstico diferencial con otras patologías respiratorias más frecuentes. El diagnóstico definitivo es histopatológico. Su tratamiento es quirúrgico y debe realizarse seguimiento a largo plazo por la posibilidad de recidiva. Se comunica caso de una paciente portadora de un tumor fibroso de la pleura, que se manifestó por dificultad respiratoria, dolor torácico y signología clínica de ocupación pleural. El diagnóstico se determinó mediante biopsia por punción percutánea del tumor. La paciente fue sometida a toracotomía, realizándose extirpación completa del tumor, con buena evolución postoperatoria
Subject(s)
Humans , Female , Middle Aged , Neoplasms, Fibrous Tissue/diagnosis , Pleural Neoplasms/diagnosis , Biopsy, Needle , Neoplasms, Fibrous Tissue/surgery , Pleural Neoplasms/surgery , Pleural Neoplasms/classification , Pleural Neoplasms/pathology , Pleura/pathology , ThoracotomyABSTRACT
Recientemente, se describió una nueva entidad de apariencia tumoral en los tejidos blandos (extremidades, tronco, escroto, nunca y axila) así como en la pleura, que se denomina seudotumor fibroso pleura, que se denomina seudotumor fibroso calcificado. No conocemos reportes previos en el mediastino. El caso que informamos es de un hombre de 44 años de edad que acudió al Hospital por dolor torácico y opacidad hiliar izquierda en la radiografía de tórax. La tomografía computarizada, muestra un tumor en el mediastino medio, de 7.6 X 6.1 cm de diámetro mayor con 1380 UH en las zonas de calcificación. Asienta arriba del cayado de la arteria pulmonar y bronquio principal izquierdo. Histopatológicamente está circunscrita, encapsulada y compuesta de tejido fibroso hialinizado, con infiltrado linfoplasmocitario, calcificaciones sammomatosas y distróficas, es menester distinguirlo del tumor fibroso de la pleura, del granuloma hializado y del seudotumor inflamatorio. Su tratamiento es la resección y no conocemos hasta el momento reportes de recidiva