Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 55
Filter
1.
Nigerian Dental Journal ; 31(1)24/06/2023.
Article in English | AIM | ID: biblio-1442817

ABSTRACT

Introduction: Anterior teeth are valuable for aesthetics, speech and mastication. Their absence, impaction, and/or delayed eruption reate significant distress often leading to early presentation to the dental office. This study presents an audit of the management of impacted anterior teeth that presented at a tertiary level dental clinic. The periodontal outcomes of the aligned teeth were also reported. Methods: This is an observational study spanning a nine-year period. Demographic data, clinical presentation, as well as post alignment dental and periodontal status of the impacted teeth were assessed. Data were analysed using the Statistical Package for Social Sciences (SPSS) version 26. Fisher's exact test and paired samples T-test were used for categorical and continuous variables respectively. Significance was set at P < 0.05. Results: Twenty-eight (1.76%) cases presented with failed eruption of 32 anterior teeth were observed during the period under review. Eight patients were treated by extraction, orthodontic treatment, and space closure or prosthetic replacement, with a mean treatment time of 2.83 ± 2.66 years. Thirteen patients completed treatment by orthodontic alignment with mean alignment time of 1.4 ± 1.5 years and treatment time of 3.6 ± 2.5 years. Average loss of root length observed was 1.5mm. There was significant difference in the post-operative root length of aligned teeth compared to their normal antimeres (p < 0.005). Conclusion: Patients with impacted anterior teeth presented later than was beneficial for spontaneous alignment of their teeth. The average 1.5mm loss of root length observed was not detrimental to the anatomical retention or function of the aligned teeth. There is need for more enlightenment with regards to early presentation for dental problems to avoid expensive and time-consuming treatments.


Subject(s)
Tooth, Unerupted , Treatment Outcome , Odontodysplasia
2.
Int. j. odontostomatol. (Print) ; 13(3): 310-315, set. 2019. graf
Article in Spanish | LILACS | ID: biblio-1012428

ABSTRACT

RESUMEN: La odontodisplasia regional (OR) es una alteración en el desarrollo, no hereditario y que afecta tanto la dentición temporal como la dentición definitiva. Involucra a los tejidos mesodérmicos y ectodérmicos de los dientes lo que es condescendiente con hallazgos clínicos, radiográficos e histológicos. Su etiología aun es desconocida y se presenta mayoritariamente en mujeres. Clínicamente puede afectar al maxilar, a la mandíbula o ambas arcadas pero generalmente solo se ve comprometida una ellas, principalmente el más afectado es el hueso maxilar. Radiográficamente se observa una pobre diferencia entre los tejidos del esmalte y la dentina, siendo tejidos menos radiopacos que su contraparte sana generando un aspecto descrito como "diente fantasma". Histológicamente se observan zonas hipocalcificadas del esmalte con un orden de prismas irregulares mientras que la dentina se observa con un número reducido de túbulos dentinarios y de consistencia más fibrosa en su zona coronal. El tratamiento de la OR es controversial ya que su incidencia es baja y la literatura al respecto no es clara. El objetivo de este manuscrito, fue reportar un caso de OR y revisar la literatura relacionada. Presentamos un caso de OR en una paciente de 12 años que presenta ausencia de los dientes 2.4, 2.5 y 2.6; restos radiculares y agenesia de los dientes 3.5 y 4.5. Se describirán sus aspectos clínicos, radiográficos e histológicos. Se realizó una búsqueda sistemática en las siguientes bases de datos: Clínical key, Science Direct, PubMed y SciELO.


ABSTRACT: Regional odontodysplasia (RO) is a variation in the development; it is not hereditary and it affects both deciduous and permanent dentition. It involves the mesodermal and ectodermal tissues of dental pieces, and coincides with clinical, radiographic and histological findings. Its etiology is still unknown and it reportedly occurs mostly in women. Clinically it can affect the maxilla, mandible or both arches but generally only one is compromised, mainly the maxilla which is affected the most. Radiographically there is limited difference between enamel and dentin tissue, which is less radiopaque than their healthy counterpart, generating an aspect described as "phantom tooth". Histologically hypocalcified areas of the enamel are observed with an irregular order of prisms while the dentine is observed with a reduced number of dentinal tubules and more fibrous consistency in the coronal area. RO treatment is controversial since its incidence is low and the literature on these events is not clear. The aim of this manuscript was to report a case of RO and review related literature. We present a case of RO in a 12-year-old patient who presents absence of parts 2.4.2.5 and 2.6; radicular remains and agenesis of parts 3.5 and 4.5. Its clinical, radiographic and histological aspects are described. A systematic search was carried out in the following databases: Clinical key, Science Direct, PubMed and SciELO.


Subject(s)
Humans , Female , Child , Odontodysplasia/diagnosis , Mandible/pathology , Molar/abnormalities , Radiography, Panoramic , Odontodysplasia/pathology , Dental Enamel/abnormalities
3.
Braz. dent. sci ; 21(3): 307-314, 2018. ilus, tab
Article in English | LILACS, BBO | ID: biblio-911404

ABSTRACT

Odontogenic lesions comprise a diverse group of lesions which usually affect the oral cavity and are derived from embryonic dental tissues. Their mechanisms of development and progression are still not fully known, but there are some studies investigating the participation of specific proteins in these events. Objective: The objective of this study was to investigate the expression of KRAS protein in these pathologies and also to associate the protein expression with the behaviour of the lesions studied. Material and Methods: Immunohistochemical analysis of 20 cases was performed for each one of the following lesions: dentigerous cyst (DC), odontogenic keratocyst (OKC) and ameloblastoma (AB), totalising 60 cases to be analysed. Results: By considering the KRAS immunoexpression, there were 11 cases (55%) presenting overexpression (score 3) in the basal layer of DC and 13 cases (65%) in the suprabasal layer. A similar finding was observed in the analysis of OKC, with eight cases (40%) in the suprabasal layer (score 3) and only five cases (25%) in the basal layer. As for AB, the overexpression was observed in six cases (30%). Conclusion: Therefore, it one suggests that the KRAS expression in odontogenic lesions is inversely proportional to their aggressive behaviour. (AU)


As lesões odontogênicas compreendem um grupo diversificado de lesões que comumente acometem a cavidade oral e são derivadas dos tecidos que originam o dente. Seus mecanismos de desenvolvimento e progressão ainda não são completamente conhecidos, porém alguns estudos investigam a participação de algumas proteínas específicas nesses eventos. Objetivo: O objetivo desse estudo foi investigar a expressão da proteína KRAS nestas patologias e associar a expressão proteica com o comportamento das lesões estudadas. Material e Métodos: A análise imuno-histoquímica foi realizada em 20 casos cada uma das lesões: cisto dentígero (CD), ceratocisto odontogênico (CO) e ameloblastoma (Am), totalizando 60 casos analisados. Resultados: Considerando-se a imunoexpressão de KRAS na camada basal do CD, 11 (55%) casos apresentaram hiperexpressão (score 3), já na camada suprabasal em 13 (65%) casos. Resultado semelhante foi observado na análise do CO, onde a camada suprabasal obteve 8 (40%) casos com score 3, enquanto a camada basal atingiu esse nível em apenas 5 (25%) casos. Em relação ao Am a hiperexpressão foi observada em 6 (30%) dos casos. Conclusão: Portanto, sugere-se que a expressão de KRAS nas lesões odontogênicas seja inversamente proporcional ao comportamento agressivo dessas lesões. (AU)


Subject(s)
Ameloblastoma , Dentigerous Cyst , Immunohistochemistry , Odontodysplasia , Odontogenic Cysts
4.
Rev. odontopediatr. latinoam ; 8(2): 112-122, 2018. tab
Article in Spanish | LILACS, COLNAL | ID: biblio-999351

ABSTRACT

Objetivo: Determinar la prevalencia de complicaciones sistémicas derivadas de celulitis facial odontogénica y su relación con el peso y la talla de niños de 1 a 6 años hospitalizados en el Servicio de Infectología Pediátrica del Hospital Universitario de Caracas en el periodo 2006-2014. Materiales y métodos: Se realizó un estudio epidemiológico de prevalencia, no experimental, retrospectivo, transversal y analítico en una muestra seleccionada a conveniencia de 310 niños en edades entre 1 y 6 años, con análisis de frecuencias, porcentajes, promedios, prueba de significancia estadística chi cuadrado, correlación de Pearson y Odds-Ratio. Resultados: la prevalencia de complicaciones sistémicas derivadas de la celulitis facial odontogénica en esta muestra fue del 32%, y se reportan 5: meningitis 15%, absceso cerebral 2%, neumonía 6%, endocarditis infecciosa 5% y septicemia 4%. El 65,48% y el 68,06% de la muestra total presentó talla baja y peso bajo respectivamente. El peso bajo se relacionó estadísticamente con la presencia de complicaciones sistémicas en esta población. Al comparar con niños de talla y peso normal, los niños con baja talla (percentil 10) tuvieron una probabilidad 3 veces mayor de presentar complicaciones y los de bajo peso (percentil 10) presentaron 4 veces más probabilidades de presentar complicaciones sistémicas. Conclusiones: las complicaciones sistémicas que se pueden derivar de una celulitis facial odontogénica son varias y pueden comprometer la vida del paciente, en este estudio la más frecuente fue la meningitis. El peso y la talla son variables importantes a considerar al evaluar y tratar enfermedades infecciosas odontogénicas en la población pediátrica ya que pueden ser factores de riesgo en la aparición de complicaciones sistémicas asociadas.


Determinar a prevalência de complicações sistêmicas de celulite facial odontogenica e sua relação com o peso e altura de crianças de 1 a 6 anos hospitalizadas nas Serviço de Doenças Infecciosas Pediátricas del Hospital Universitário de Caracas, no período 2006-2014. Materiais e métodos. Um estudo epidemiológico de prevalência foi realizado, não-experimental, retrospectivo, transversal e analíticas em uma amostra de conveniência selecionada de 310 crianças de 1 a 6 anos, com análise de freqüência, porcentagens, médias, teste de shows de significância estatística chi quadrado, de correlação de Pearson e Odds ratio. Resultados. A prevalência de complicações sistémicas de celulite facial odontogénica nesta amostra foi de 32%, e relatou 5: 15% meningite, abcesso cerebral 2%, 6% pneumonia, endocardite infecciosa e septicemia 5% 4%. O 65,48% e ele 68,06% e a amostra total mostrou LHA e peso respectivamente. Baixo peso foi estatisticamente relacionada com a presença de complicações sistêmicas nesta população. Quando comparado com crianças de estatura normal e peso, crianças com baixa estatura (percentil 10) tinha 3 vezes mais propensos a ter complicações e baixo peso ao nascer (percentil 10) apresentou 4 vezes mais propensos a ter complicações Conclusões. Complicações sistémica que pode ser derivada a partir de celulite facial odontogénica são vários e podem comprometer a vida do paciente, no presente estudo o mais frequente foi a meningite. O peso e tamanho são variáveis importantes a considerar quando se avalia e tratamento de doenças infecciosas em pediátrica odontogénica população, pois podem ser factores de risco associados com o aparecimento de complicações sistémicas. Palavras-chave: celulite odontogenic facial, complicações sistêmicas, baixo peso, baixa estatura.


Aim: To determine the prevalence of systemic complications derived from odontogenic facial cellulitis and its relation to weight and height of children from 1 to 6 years hospitalized in the Pediatric Infectology Service of the University Hospital of Caracas in a period between 2006 and 2014. Materials and methods: An epidemiological and prevalence, non-experimental, retrospective, cross-sectional and analytical study was performed in convenience sample selected from 310 children aged 1 to 6 years. Data was analyzed by frequencies, percentages, averages, chi square test, Pearson correlation and Odds-Ratio. Results: The prevalence of systemic complications derived lofrom odontogenic facial cellulitis in this sample was 32% including: meningitis 15%, brain abscess 2%, pneumonia 6%, infective endocarditis 5% and septicemia 4%. 65.48% of the total sample presented low height and 68.06% low weight. Low weight was statistically related to the presence of systemic complications in this population. When compared with children of normal height and weight, children with low height (10th percentile) were 3 times more likely to present systemic complications and low weight children (10th percentile) 4 times higher chance for systemic complications. Conclusions: There are several systemic complications derived from an odontogenic facial cellulitis and can compromise the patient´s life. In this study the most frequent was meningitis. Weight and height are important variables to consider when evaluating and treating odontogenic infectious diseases in the pediatric population, since may constitute risk factors in the development of associated systemic complications.


Subject(s)
Humans , Child , Odontodysplasia , Dental Caries/complications , Focal Infection, Dental , Cellulite/complications , Infections/complications , Meningitis
5.
HU rev ; 43(4): 421-425, 2017.
Article in Portuguese | LILACS | ID: biblio-980622

ABSTRACT

A Odontodisplasia Regional é uma anomalia dental rara, que envolve os tecidos dentários de origem ectodérmica (esmalte) e mesodérmica (dentina, polpa e cemento). O objetivo deste trabalho foi relatar um caso clínico de odontodisplasia regional em uma criança. Paciente de nove anos, sexo masculino, tendo como queixa principal a ausência de alguns dentes decíduos e a não irrupção dos dentes permanentes em determinada região da maxila. O dente 16, que havia irrompido, apresentava-se clinicamente, com um esmalte hipoplásico e hipomineralizado e uma imagem radiográfica bastante tênue, por isso sendo conhecido como "dente fantasma". Foram apresentados nesse relato, aspectos clínicos e radiográficos e destacadas as questões envolvidas na elaboração de um plano de tratamento. Há poucos estudos disponíveis sobre a odontodisplasia regional. A anamnese detalhada e o conhecimento das características clínicas e radiográficas são imprescindíveis para um correto diagnóstico.


Regional Odontodysplasia is a rare dental anomaly involving dental tissues of ectodermal (enamel) and mesodermal (dentin, pulp and cement) origin. The aim of this study was to report a case of regional odontodysplasia in a child. A nine-year-old male patient who the main complaint was the absence of some deciduous teeth and the non - eruption of permanent teeth in a specific area of the maxilla. The tooth 16, which had erupted, had hypoplastic and hypomineralized enamel, presenting a radiographic image lacking clearness, for that reason being known "ghost teeth". In this case report, clinical and radiographic aspects were presented and were highlighted the issues involved in the elaboration of a treatment plan. There are few available studies about regional odontodysplasia. The detailed anamnesis and the knowledge of the clinical and radiographic characteristics are essential for a correct diagnosis.


Subject(s)
Pediatric Dentistry , Odontodysplasia , Patient Care Planning , Tooth, Deciduous , Odontodysplasia/diagnostic imaging , Dental Cementum , Dental Enamel/abnormalities
6.
Int. j. odontostomatol. (Print) ; 9(1): 129-136, Apr. 2015. ilus
Article in Spanish | LILACS | ID: lil-747489

ABSTRACT

El papel que desempeñan las alteraciones genéticas en el desarrollo dental es fundamental. Se ha descubierto que si no existe una correcta expresión del gen o se da una mutación de este, el individuo podría presentar ausencias o malformaciones de estructuras de la boca. Por esta razón se describe la forma en que se da el desarrollo de las estructuras dentales, teniendo en cuenta cómo las interacciones genética y ambiental influyen en su correcto desarrollo. Entre los genes involucrados se encuentran el PAX9 y el MSX1, que según recientes investigaciones son los implicados en las ausencias congénitas de estructuras dentarias o sus posibles alteraciones, teniendo en cuenta que la delación de estos genes o su mutación son factores hereditarios. Los genes odontogénicos PAX9 y MSX1, son genes homeóticos (homebox) que codifican para factores de transcripción y son responsables, durante la odontogénesis, de la expresión de genes asociados con la regulación espacial y temporal dentro del primer arco braquial. En determinado momento de la organogénesis pueden darse fallas en la expresión de los factores necesarios para la formación y buen desarrollo dental, causando anomalías como la Odontodisplasia Regional (OR), también denominada diente fantasma o detención localizada del desarrollo dental, la cual es una anomalía estructural del desarrollo, compleja y rara; parece ser el resultado de una o más mutaciones puntuales en el cromosoma 4 y 14. Se reportan dos casos donde se describen las características clínicas, radiográficas, y el seguimiento clínico.


The role of genetic alterations in tooth development is essential. It has been discovered that if there is a correct expression of the gene or there is a mutation of this, the individual could present absence or malformations of structures of the oral cavity or other body parts. For this reason we describe how given the development of dental structures, taking into account how genetic and environmental interactions influence their proper development. Among the genes involved are in the PAX9 and MSX1, which according to recent research are involved in congenital absence of dental structures or alterations, considering that the denunciation of these genes or the mutation is inherited. The odontogenic PAX9 and MSX1 genes are homeotic genes (homebox) that encode for transcription factors and are responsible, during odontogenesis, the expression of genes associated with spatial and temporal regulation within the first brachial arch. At some point during organogenesis may be flaws in the expression of the factors necessary for the formation and tooth development, causing among other abnormalities Regional Odontodysplasia (RO), also called ghost tooth or detention tooth dental development located, which is a structural anomaly development complex and rare; seems to be the result of one or more point mutations in the chromosome 4 and 14. In this report we show two cases with odontodysplasia where there are clinical and radiographic features of two patients with this anomaly, one of them has been made up and treatment, and the other begins his analysis stage.


Subject(s)
Humans , Male , Female , Child , Adolescent , Odontodysplasia/pathology , Maxilla/abnormalities , Orthodontics , Radiography, Panoramic , Odontodysplasia/diagnosis , Endodontics , Anodontia , Morphogenesis , Odontogenesis
7.
Article in English | IMSEAR | ID: sea-154555

ABSTRACT

Segmental odontomaxillary dysplasia (SOD) is an uncommon, nonhereditary, rare developmental disorder primarily involving the posterior part of the maxilla and related dental components. It is a rare condition of uncertain etiology that results in painless unilateral expansion of the posterior dentoalveolar complex, gingival hyperplasia, lack of one or both premolars in the affected area, delayed eruption of adjacent teeth and malformations of the primary molars. Radiographically, the affected bone is thickened and irregular in outline, with a coarse trabecular pattern that is vertically oriented resulting in a relatively radioopaque granular appearance. The treatment is focused on extraction of the involved teeth, while in some milder cases the teeth may be retained for a long period. The treatment plan should be based on the degree of involvement as well as the functional and esthetic needs in each case. Considering the rarity of the condition, we report three cases of SOD with variable presentations in a 45-year-old, 24-year-old and 23-year-old individual.


Subject(s)
Adult , Gingival Hyperplasia/epidemiology , Humans , Maxilla/abnormalities , Odontodysplasia/epidemiology , Young Adult
8.
São Paulo; s.n; 2014. 87 p. ilus, tab. (BR).
Thesis in Portuguese | LILACS, BBO | ID: biblio-867367

ABSTRACT

O estudo das células-tronco cancerígenas (CTCs) durante o processo de malignização e no carcinoma epidermóide intra-bucal já instalado é essencial para um melhor entendimento de como essas células participam da formação e manutenção de uma neoplasia. Atualmente, a identificação de células com características de células tronco se dá principalmente através da expressão de marcadores celulares como o ALDH1 e o CD44. A proteína ALDH1 é responsável pela oxidação de aldeídos intracelulares e vem sendo utilizada para o isolamento de CTCs em inúmeros canceres incluindo casos de cabeça e pescoço. A proteína CD44 é uma glicoproteína envolvida na adesão e migração celular, também participa do processo de metástase e já foi associada às CTCs. Nesse trabalho, a expressão dessas proteínas foi analisada em 45 casos de displasias epiteliais e 13 casos de carcinomas epidermóide intra-bucais. As lesões displásicas foram classificadas em casos leves (19), moderados (18) e intensos (8) e foram também divididas em casos de baixo risco (22) e alto risco de transformação maligna (23). A expressão imunohistoquímica para a ALDH1 foi encontrada predominantemente na camada basal em 16 casos de displasias epiteliais e em 7 carcinomas epidermóides, com a marcação difusa pela epitélio neoplásico. A expressão imunohistoquímica de CD44 foi encontrada em 42 displasias epiteliais e em 12 carcinomas epidermóides, sendo que nas displasias, a expressão ocorreu predominantemente na camada basal do epitélio e no carcinoma epidermóide a expressão foi disseminada. Ambos marcadores exibiram aumento de expressão com a evolução do grau das displasias.


The study of cancer stem cells (CTCs) in the process of malignant transformation and intra-oral squamous cell carcinoma already installed is essential for a better understanding of how these cells participate in the formation and maintenance of a neoplasm. Currently, identification of cells with characteristics of stem cells is primarily through the expression of cell markers such as CD44 and ALDH1. The ALDH1 protein is responsible for the oxidation of intracellular aldehydes and has been used for the isolation of CTCs in numerous cancers including head and neck cases. The CD44 protein is a glycoprotein involved in cell adhesion and migration, also participates in the process of metastasis and has been associated with CTCs. In this work, the expression of these proteins was analyzed in 45 cases of epithelial dysplasia and 13 cases of intraoral squamous cell carcinomas. The dysplastic lesions were classified as mild (19), moderate (18) and intense (8) cases and were also divided into low-risk cases (22) and high risk of malignant transformation (23). The immunohistochemical expression for ALDH1 was found predominantly in the basal layer in 16 cases of epithelial dysplasia and squamous cell carcinoma in 7, with diffuse labeling by neoplastic epithelium. Immunohistochemical expression of CD44 was found in 42 epithelial dysplasias and 12 squamous cell carcinomas, and in dysplasias, the expression occurred predominantly in the basal layer of the epithelium and in squamous cell carcinoma expression was widespread. Both markers showed increased expression with the evolution of the degree of dysplasia.


Subject(s)
Carcinoma, Squamous Cell/classification , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/diagnosis , Mouth Neoplasms/classification , Mouth Neoplasms/complications , Mouth Neoplasms/diagnosis , Odontodysplasia/diagnosis
9.
São Paulo; s.n; 2014. 206 p. ilus, tab. (BR).
Thesis in Portuguese | LILACS, BBO | ID: lil-763785

ABSTRACT

O câncer de mucosa oral é um problema de saúde pública, com maior incidência em homens acima de 50 anos. Uma das manifestações clínicas mais precoces do câncer da mucosa oral são as lesões leucoqueratósica. O aspecto clínico não homogêneo e o tamanho maior de 200mm2, em mucosa não queratinizada como a do assoalho da boca e ventre da língua, são aspectos que implicam na possibilidade de evolução da lesão. A dificuldade do diagnóstico das lesões precoces está na seleção do local a ser biopsiado principalmente frente a lesões extensas e heterogêneas. O objetivo desta pesquisa é avaliar se a utilização do exame clínico juntamente com os métodos auxiliares de diagnóstico das lesões leucoqueratósica da mucosa oral (VELscope®, Azul de toluidina e Solução de lugol) contribui para uma maior precisão do diagnóstico de displasias nestas lesões quando comparado ao histopatológico. E, identificar os padrões morfológicos destas lesões quando avaliadas por meio da microscopia confocal reflectante. Foram selecionados 30 pacientes, maiores de 18 anos, portadores de lesão clínica compatível com leucoplasia oral triados no ambulatório da disciplina de Estomatologia Clínica da Faculdade de Odontologia da Universidade de São Paulo e que precisavam ser submetidos à biópsia para o estabelecimento do diagnóstico final. Foram realizados os testes de Azul de Toluidina, Solução de Lugol, VELscope®, microscopia confocal reflectante e posteriormente, a biópsia incisional para obtenção do diagnóstico final. Os pacientes incluídos possuíam média de idade 60,66 anos, sendo 70% (21/30) do gênero feminino e 30% (9/30) do gênero masculino. O tabagismo foi relatado por 16,7% (5/30) dos pacientes, sendo 60% (3/5) homens. A associação do tabagismo e etilismo foi relatada em 10% (3/30) dos pacientes, o tabagismo isoladamente por 6,6% (2/30) e o de etilismo por 3,3%(1/30)...


Cancer of the oral mucosa is a public health problem, with higher incidence in men above 50 years. One of the earliest manifestations of cancer of the oral mucosa lesions are leukokeratosis. The inhomogeneous clinical aspect and the larger size of 200mm2 in non-keratinized mucosa as the floor of the mouth and constipation of the tongue, are aspects that imply the possibility of evolution of the lesion. The difficulty of diagnosis of early lesions is in the selection of the site to be biopsied primarily against large and heterogeneous lesions. The objective of this research is to evaluate the use of clinical examination along with diagnostic aids leucoqueratósica of oral lesions (VELscope ®, Toluidine blue and Lugol solution) methods contributes to greater accuracy of diagnosis of dysplasia in these lesions when compared the histopathological. And identify the morphological patterns of these lesions when evaluated by reflectance confocal microscopy. 30 patients older than 18 years, with clinical lesion compatible with oral leukoplakia screened in the outpatient discipline of Clinical Dentistry, Faculty of Dentistry, University of São Paulo and that needed to be biopsied to establish the final diagnosis were selected. Tests toluidine blue, Lugol's solution, VELscope ®, reflectance confocal microscopy (RCM) and subsequently, incisional biopsy to obtain the final diagnosis were performed. Patients enrolled had a mean age 60.66 years, 70% (21/30) were female and 30% (9/30) were male. Smoking was reported by 16.7% (5/30) of patients, 60% (3/5) homens.A association of smoking and alcohol use was reported in 10% (3/30) of patients, smoking alone by 6.6% (2/30) and of alcoholism by 3.3% (1/30)...


Subject(s)
Humans , Male , Adult , Middle Aged , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/diagnosis , Diagnosis, Oral/methods , Epithelium , Leukoplakia, Oral/classification , Leukoplakia, Oral/complications , Leukoplakia, Oral/diagnosis , Odontodysplasia/complications , Odontodysplasia/diagnosis
10.
11.
Dermatol. peru ; 23(2): 73-77, abr.-jun. 2013. ilus, tab, graf
Article in Spanish | LILACS, LIPECS | ID: lil-765201

ABSTRACT

OBJETIVO. Determinar las características clínicas y epidemiológicas de la celulitis facial odontogénica (CFO) en pacientes hospitalizados en el Servicio de Dermatología del Instituto Nacional de Salud del Niño (INSN), Lima, Perú. MATERIAL y METODOS. Estudio descriptivo de tipo serie de casos realizado en pacientes hospitalizados por celulitis facial odontogénica entre setiembre 2010 y agosto 2011. Los pacientes fueron captados prospectivamente y previo consentimiento informado fueron evaluados obteniéndose datos epidemiológicos y clínicos como edad, sexo, dolor dental al inicio de la enfermedad, eritema, edema facial, disminución de la apertura bucal, fiebre, uso de antibióticos previos a su hospitalización, responsable de la prescripción, evaluación odontológica y cifra de hemoglobina. Para esto se elaboró una ficha de recolección de datos. RESULTADOS. Durante el período de estudio fueron hospitalizados 28 pacientes con el diagnóstico de celulitis facial y 22 (78,6%) tuvieron las características clínicas de una CFO. Se observó mayor frecuencia de casos en el sexo femenino (59%) y en niños de cuatro a seis años (59%). El uso de antibióticos previos a la hospitalización fue reportado en 19 pacientes (86.3%) observándose hasta nueve esquemas de tratamiento, siendo la indicación de amoxicilina la más frecuente (57,9%). El examen odontológico fue positivo en el 100% con reportes en el odontograma de pulpitis irreversible y necrosis pulpar (15,6%) y periodontitis apical crónica (2,2%). La evaluación de las cifras de hemoglobina demostró que estaban por debajo del percentil 50. Todos los pacientes fueron tratados con clindamicina EV y a su alta recibieron un ciclo adicional de amoxicilina/ ácido clavulánico siendo sometidos además al tratamiento odontoquirúrgico sin evidencia de complicaciones...


OBJECTIVE. Determine the clinical and epidemiological characteristics of the odontogenic facial cellulitis on patients who are hospitalized in the dermatology department of the National Institute of Child Health (insn), Lima-Peru. MATERIAL AND METHODS. Prospective and descriptive study of patients diagnosed as CFO of 01/09/2010 to 31/08/2011. The clinic tab allowed collecting epidemiological information according to age, sex, dental pain at the beginning of the disease, erythema, facial edema, decreased of mouth opening, fever, antibiotic use before hospitalization, responsible for the prescription, evaluation dental and hemoglobin concentration. RESULTS. ln a period of 12 months 28 patients were hospitalized with the diagnosis of facial cellulitis and 22 (78,6%) had clinical features of odontogenic facial cellulitis (CFO )./n relation to female gender had more cases, 13 (59%), while male just had 9 (41%), children over 4 years and under age 6 had the highest number 13 (59,1%), antibiotics were indicated before hospitalization in 19 (86,3%). Were used 9 schemes and amoxicillin as the only drug in 11 (57,9%). The dental examination was positive in 100% with reports the dental irreversible pulpitis and pulp necrosis in 15,64% chronic apical periodontitis. The evaluation showed that hemoglobin levels were below the 50th percentile. All the patients were treated with clindamycin EV and when they were discharged the received one extra round of amoxicillin/clavulanic acid they also had the odontoquirurgical treatment without complications...


Subject(s)
Humans , Male , Female , Child , Cellulite , Medical Illustration , Bacterial Infections , Odontodysplasia , Epidemiology, Descriptive
12.
RGO (Porto Alegre) ; 60(2): 247-251, abr.-jun. 2012. ilus
Article in English | LILACS, BBO | ID: biblio-874645

ABSTRACT

The present article reports on a case of a dental development anomaly in an 18-month old patient whose parents sought treatment with the chief complaint of ?missing teeth?. The diagnosis of regional odontodysplasia or ?ghost teeth? involving incisors and canine, both deciduous and permanent, of the upper right side of the mouth was based on radiographic features of the condition: marked reduction of enamel and dentin radiopacity, which are present in thin layers involving large pulp cavity of the teeth affected, usually belonging to a particular quadrant. At the age of three years and six months, the patient was still under observation, and received partial denture rehabilitation as a first step, since the clinical condition of the element 51 resulted in its extraction and the beginning of the child?s school life required esthetic and functional rehabilitation. The other affected teeth were preserved, contributing to the alveolar development. The patient remains under regular follow-up and the treatment plan for the permanent dentition will depend on the degree of dental involvement.


O presente artigo relata um caso de anomalia de desenvolvimento dentário em paciente aos dezoito meses de idade, cujos pais buscaram atenção odontológica com a queixa de ?falta de dentes?. O diagnóstico de Odontodisplasia regional ou ?dentes fantasma? envolvendo incisivos e canino, decíduos e permanentes, do quadrante superior direito foi baseado nas características radiográficas da condição: marcante redução na radiopacidade de esmalte e dentina, que se apresentam em finas camadas envolvendo ampla cavidade pulpar nos dentes afetados, geralmente pertencentes a um quadrante particular. Aos três anos e meio de idade, estando em controle periódico, a paciente recebeu prótese parcial removível como primeira medida reabilitadora, uma vez que a condição clínica do elemento 51 implicou sua perda, e o início da vida escolar da criança exigia reabilitação estética e funcional. Os demais dentes afetados foram conservados, contribuindo para o bom desenvolvimento alveolar. A paciente permanece em acompanhamento regular, sendo que o plano de tratamento para a dentição permanente dependerá do grau da anomalia em seus elementos.


Subject(s)
Infant , Child , Tooth Abnormalities , Tooth, Deciduous , Odontodysplasia , Pediatric Dentistry
13.
São Paulo; s.n; 2012. 96 p. ilus, tab, graf. (BR).
Thesis in Portuguese | LILACS, BBO | ID: lil-668579

ABSTRACT

A displasia fibrosa é uma alteração de desenvolvimento caracterizada pela substituição do osso normal por tecido conjuntivo denso e trabéculas ósseas imaturas, geralmente encontrada em adolescentes e adultos jovens. Uma alteração genética que envolve a proteína Gs-alfa parece ser a base do processo. A exata incidência e prevalência são difíceis de estabelecer, mas as lesões representam cerca de 5% a 7% dos tumores ósseos benignos. Nos ossos craniofaciais tem predileção pela maxila, podendo causar deformidade grave e assimetria, afetando igualmente ambos os sexos. Radiograficamente, pode apresentar diferentes padrões de imagem dependendo do grau de mineralização e maturação da lesão. .A avaliação da displasia fibrosa nas radiografias da região craniofacial pode ser difícil por causa das aparências variáveis e das estruturas que se sobrepõem, de modo que a tomografia computadorizada é um recurso relevante para o seu correto diagnóstico e planejamento de tratamento. O objetivo deste estudo foi caracterizar a displasia fibrosa através da análise da lacunaridade, um método multiescala para descrever padrões de dispersão espacial. Foram avaliados 10 pacientes (6 homens e 4 mulheres) comprometendo a maxila em sua grande maioria.


Para a análise da lacunaridade, empregou-se cortes tomográficos axiais e coronais e, posteriormente, selecionou-se as regiões de interesse das áreas displásicas e do osso normal contralateral por meio do software MATLAB®. Após testes e análises estatísticas, concluiu-se que os cortes coronais, com ampliação de 3x do seu tamanho original, mostraram superioridade em relação aos axiais e, que a lacunaridade foi menor nas áreas da região displásica em relação ao osso normal, ou seja, a primeira apresentou uma maior homogeneidade de textura que a segunda. Mediante isso, pela técnica da validação cruzada leave-one-out é possível separar os grupos com uma alta acurácia (94,75%) concluindo-se que a lacunaridade é um método de análise de imagens contributivo na caracterização da displasia fibrosa.


Fibrous dysplasia is an alteration of development characterized by replacing normal bone for dense connective tissue and immature trabecular bones, typically found in teenagers and young adults. Genetic modification which involves alpha-Gs protein appears to be the basis of the process. The exact incidence and prevalence are difficult to be established, but injuries represent about 5% to 7% of benign bone tumors. On the craniofacial bones, the tumors have a predilection for the maxilla and often can cause severe deformity and asymmetry affecting both sexes equally. Radiographically, it may have different patterns depending on the image degree of mineralization and maturation of the lesion. The evaluation of radiographs of fibrous dysplasia in the craniofacial region can be difficult because of the different appearances and structures that overlaps, however, CT is an important resource for proper diagnosis and treatment planning.


The aim of this study was to characterize the fibrous dysplasia by analyzing the lacunarity which is a multiscale method to describe patterns of spatial dispersion. We evaluated 10 patients (6 males and 4 females) and the maxillary was the most affected area. To the lacunarity analysis, we used an axial and coronal view and then were selected the regions of interest in the areas of dysplastic and contralateral normal bone by means of MATLAB® software. After tests and statistical analysis can be conclued that the coronal magnification 3x its original size showed superiority compared to thrust, and that the lacunarity was lower in the areas of dysplastic region in relation to normal bone, namely the first presented a more uniform texture than the second. Through this, the technique of cross-validation "leave-one-out" is possible to separate the groups with a high accuracy (94.75%) concluding that the lacunarity is a method of image analysis to characterize the contributory fibrous dysplasia.


Subject(s)
Humans , Male , Female , Fibrous Dysplasia of Bone/diagnosis , Odontodysplasia/diagnosis , Tomography, Spiral Computed , Tomography
14.
Rev. odonto ciênc ; 27(3): 246-250, 2012. ilus
Article in English | LILACS, BBO | ID: lil-656794

ABSTRACT

PURPOSE: Regional odontodysplasia (RO) is a rare condition characterized by distinctive clinical, radiographic and microscopic findings. It is presumed to be the result of a developmental disturbance that locally affects the odontogenic ectodermal and mesodermal tissues. This report describes the clinical and radiographic findings of RO and its treatment. CASE DESCRIPTION: A 15-year-old boy presented with an uncommon case of RO involving two quadrants of the jaws on the right side of his face. CONCLUSION: A complex multidisciplinary team is required to fully rehabilitate a patient affected by RO. The treatment of RO is controversial and varies according to the individual patient.


OBJETIVO: Odontodisplasia regional (OR) é uma condição rara caracterizada por achados clínicos, radiográficos e microscópicos bem distintos. É o resultado de um distúrbio de desenvolvimento bem localizado afetando tanto o ectoderma quanto o mesoderma odontogênico. Este trabalho descreveu os achados clínicos e radiográficos de um caso de OR e os tratamentos. DESCRIÇÃO DO CASO: Um menino de 15 anos de idade apresentou um caso incomum de OR envolvendo dois quadrantes dos maxilares no lado direito da face. CONCLUSÃO: Há necessidade de uma equipe multidisciplinar complexa para reabilitar inteiramente um paciente com OR. O tratamento de OR é controverso e varia de acordo com as características e resposta do paciente.


Subject(s)
Humans , Male , Adolescent , General Surgery/methods , Dentin Dysplasia/diagnosis , Odontodysplasia
15.
Article in Portuguese | LILACS, BBO | ID: lil-621691

ABSTRACT

Odontodysplasia is considered a rare dental development anomaly, which leads to enamel and dentin hypoplasia of the affected teeth, whose etiology is still uncertain and broadly discussed. At the clinical exam, the teeth with odontodysplasia are usually shorter than those of normality standards, with irregular crown shape and form, with hypoplastic, yellow or pigmented external surface. The radiographic aspect depends on the stage the anomalous tooth is x-rayed, given the different evolutional stages of the mineralization process; however, in general, there is a significant reduction in the radiopacity of all mineralized structures, with no distinction between enamel and dentin, with abnormally wide pulp chambers and, at times, unshapely. In this paper the authors present a case of three sisters with odontodysplasia and the main clinical and radiographic characteristics of this development anomaly, based on a literature review. The work at issue is of clinical relevance as it shows three odontodysplasia cases in the same family, suggesting genetic inheritance, which opposes to the researched papers


A odontodisplasia é considerada um distúrbio de desenvolvimento dentário raro, que resulta na hipoplasia de esmalte e dentina dos dentes afetados, tendo sua etiologia ainda incerta e muito discutida. Ao exame clínico, os dentes com odontodisplasia usualmente se apresentam com o tamanho menor que os padrões de normalidade, o contorno e a forma das coroas alteradas, com a superfície externa hipoplásica, amarelada ou pigmentada. O aspecto radiográfico depende da fase em que o dente anômalo é radiografado, devidos aos diferentes estágios evolutivos do processo de mineralização; contudo, em geral, há marcante redução na radiopacidade de todas as estruturas mineralizadas, não se distinguindo esmalte de dentina, surgindo câmaras pulpares anormalmente grandes e, por vezes, disformes. No presente trabalho os autores apresentam um caso de três irmãs portadoras de odontodisplasia e as principais características clínicas e radiográficas dessa anomalia de desenvolvimento, embasados em uma revisão da literatura. O trabalho em questão é de relevância clínica por se tratar de três casos de odontodisplasia na mesma família, sugerindo herança genética, o que vem de encontro aos trabalhos pesquisados


Subject(s)
Humans , Female , Adolescent , Tooth Abnormalities , Odontodysplasia
16.
São Paulo; s.n; 2011. 119 p. ilus, tab, graf. (BR).
Thesis in Portuguese | LILACS, BBO | ID: lil-620668

ABSTRACT

A queilite actinica é uma lesão que acomete o vermelhão do lábio, principalmente o inferior, devido à exposição crônica e prolongada à radiação ultravioleta solar. Sabe-se'";que uma parcela dos casos de queilite actinica evoluirá para carcinoma epidermoide de lábio, mas quantos casos e quais, exatamente, ainda não é possível dizer. O prognósticoda queilite actinica, assim como a decisão terapêutica, são, atualmente, baseados em seu aspecto histopatológico mais importante: a displasia epitelial. O objetivo deste trabalhofoi avaliar as alterações citológicas e arquiteturais do epitélio de uma ampla amostra de casos de queilite actinica. Após essa etapa, os casos foram classificados segundo doissistemas de graduação: o proposto pela OMS e o binário. Depois dessa fase, foram selecionados casos de todas as graduações para serem submetidos, pela técnica deimuno-histoquímica, aos anticorpos anti-Ki 67 e anti-p53 mutada. Um total de 458 casos foram examinado. As alterações epiteliais mais frequentemente encontradas foi a perdade polaridade do estrato basal, o pleomorfismo nuclear e celular e o hipercromatismo. As graduações mais frequentes foram lesão de baixo risco e displasia epitelial moderada.Os resultados para as proteínas Ki 67 e p53 não mostraram relação estatisticamente significante com os graus histológicos. Que seja de nosso conhecimento, esta é a maior sériede queilites actínicas já analisada histologicamente e conclui-se que fatores como a determinação de quais as alterações teciduais devem ser consideradas, a representatividade do corteexaminado e a correspondência entre as alterações morfológicas e a instabilidade genética dos tecidos comprometem o uso prognóstico dos diferentes graus de displasia epitelial.


Actinic cheilitis is a lesion that affects the lip vermilion, due to chronic and prolonged exposure to solar ultraviolet radiation. It is known that a proportion of the actiniccheilitis cases wiIl evolve into squamous ceIl carcinoma of the lip, but how many cases and which ones wiIl suffer this process is not yet possible to say. The actinic cheilitisprognosis, as weIl as, the therapeutic decision are currendy based on epithelial dysplasia degree presented, which is considered the main histological characteristic. The aim ofthis study was to evaluate the epithelium architectural and cytological changes presented in a large sample of cases of actinic cheilitis. AfteIWards, the cases were classifiedfolIowing two grading systems: After this stage, cases were classified by two grading systems: the one proposed by WHO and the binary system. After, cases of allhistological grades were selected and submitted by means of immunohistochemistry, to the antibodies against Ki-67 and mutated p53. A total of 458 cases were exarnined andthe epithelial changes most frequendy found were the loss of polarity of basal ceIl; nuclear and celIular pleomorphism; and hyperchromatism. The grades most frequendyfound were low risk and moderate epithelial dysplasia. Results for p53 protein and Ki 67 showed no statistically significant relationship with the histological grades. To the best ofour knowledge, this is the largest series of actinic cheilitis histologically analyzed. It was concluded that factors such as determining which histological changes should beconsidered, the section representativeness, hence the correspondence between the morphological changes and genetic instability, compromise the prognostic use of epithelial dysplasia grading.


Subject(s)
Humans , Male , Female , Oral Medicine/methods , Odontodysplasia/diagnosis , Cheilitis/diagnosis
17.
Chinese Journal of Stomatology ; (12): 263-266, 2011.
Article in Chinese | WPRIM | ID: wpr-339758

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the prevalence of dental anomalies in Chinese children with complete unilateral cleft lip and palate (UCLP).</p><p><b>METHODS</b>Dental histories and radiographs of 244 Chinese children with UCLP were collected. The diagnosis of dental anomalies was based on panoramic radiographs before alveolar bone grafting. All patients were over 8 years old.</p><p><b>RESULTS</b>In the UCLP group, 66.8% of the patients was presented with hypodontia. The maxillary lateral incisors were the most common teeth affected, followed by maxillary second premolars, mandibular incisors and mandibular second premolars. A total of 33.6% the patients was presented with dental malformation, most were microdontic laterel incisors. A total of 4.9% the patients was presented with hyperdontia. The supernumerary teeth were more frequently found in the cleft region. The prevalence of missing maxillary lateral incisor in the noncleft side was statistically different between genders, which was higher in male (P < 0.050). This group of Chinese children with UCLP demonstrated significantly higher prevalence of hypodontia, hyperdontia, and malformation on the cleft side than on the noncleft side (P < 0.01).</p><p><b>CONCLUSIONS</b>Hypodontia is the most common type of dental anomalies. The prevalence of dental anomalies is higher in the UCLP patients than in the normal population. Dental anomalies occur more frequently on the cleft side than on the noncleft side.</p>


Subject(s)
Child , Female , Humans , Male , Anodontia , Asian People , Bicuspid , Congenital Abnormalities , Cleft Lip , Cleft Palate , Incisor , Congenital Abnormalities , Mandible , Maxilla , Odontodysplasia , Sex Factors , Tooth Abnormalities , Tooth, Supernumerary
18.
CES odontol ; 23(2): 67-72, jul.-dic. 2010. ilus, tab
Article in Spanish | LILACS | ID: lil-612571

ABSTRACT

La odontodisplasia Regional es una anomalía del desarrollo poco frecuente de los tejidos dentarios duros, que involucra ambos tipos de denticiones y generalmente en un solo cuadrante. Lascaracterísticas clínicas son variables e incluyen decoloración dental amarilla o amarilla café, esmalte y dentina hipomineralizados, acompañadas de gingivitis, inflamación o abscesos; radiográficamente presentan cámaras pulpares amplias, y radiodensidad disminuida de esmalte y dentina dando la apariencia de dientes “fantasma”.


The Regional odontodysplasia is a rare developmental anomaly of dental hard tissues, involving both types of dentition and usually in one quadrant. Clinical features are variable and include dentaldecoloration yellow or yellowish-brown, enamel and dentin hypomineralised, accompanied by gingivitis, swelling or abscesses. Radiographically large pulp chambers are present and decreasedradiodensity of enamel and dentin giving the appearance of "ghost teeth".


Subject(s)
Humans , Dentin Dysplasia , Esthetics, Dental , Odontodysplasia
19.
Kiru ; 7(2): 81-88, jul.-dic. 2010. ilus
Article in Spanish | LILACS, LIPECS | ID: lil-619732

ABSTRACT

El propósito de este artículo de revisión es tener conceptos y criterios de clasificación actualizados y detallados de las características clínicas, radiográficas e histológicas de las patologías que alteran las estructuras dentales, con el fin de lograr un correcto diagnóstico y realizar el tratamiento más adecuado. Estas alteraciones dentales descritas son: hipoplasia del esmalte, amelogénesis imperfecta, dentinogénesis imperfecta, displasia de la dentina y odontodisplasia regional.


The purpose of this review is to have concepts and classification criteria updated and detailed clinical, radiographic and histological pathologies that alter the tooth structure in order to achieve a correct diagnosis and make the most appropriate treatment. These dental alterations described are: Enamel hypoplasia, Amelogenesis imperfecta, Dentinogenesis imperfecta, Dentin dysplasia and Regional odontodysplasia.


Subject(s)
Amelogenesis Imperfecta , Dentinogenesis Imperfecta , Dentin Dysplasia , Dental Enamel Hypoplasia , Odontodysplasia
20.
Acta odontol. venez ; 46(3): 265-268, dic. 2008. tab
Article in Spanish | LILACS | ID: lil-630074

ABSTRACT

La Leucoplasia Bucal (LB) es reconocida como una lesión que presenta características histopatológicas de Displasia Epitelial (DE). La proporción de DE que progresa a carcinoma Espino Celular es variada y se encuentra en un rango de 6,6 a 36 por ciento. El objetivo de este estudio fue establecer la correlación entre LB de la mucosa bucal con diagnóstico histopatológico de DE, para tal fin se revisaron un total de 11.250 historias, pudiéndose determinar que 180 de éstas correspondían a la patología a estudiar. Estos datos fueron analizados de acuerdo a su localización anatómica, sexo, edad, grupo étnico y grado de DE, 180 casos representaron LB con diferentes grados de Displasias, de las cuales 97(52,8 por ciento) eran DE leves, 67(37,2 por ciento) DE moderadas y 18(10,0 por ciento) DE severas. La localización anatómica más frecuentemente afectada fue la mucosa del reborde alveolar con 42 casos (24,1 por ciento), seguido por la mucosa del carrillo 35 casos (19,2 por ciento). La mayor prevalencia de edad fue del grupo de 50-59años (30,2 por ciento). El sexo femenino obtuvo el mayor número de casos. 102 casos (56,4 por ciento). En cuanto al grupo étnico el caucasoideo fue el más afectado con 98 casos (53,8 por ciento). Se reportó un 43 por ciento de pacientes con hábitos tabáquicos. Al correlacionar clínico-patológicamente los casos de este estudio se pudo evidenciar que el diagnóstico clínico de Leucoplasia esta más frecuentemente relacionada con el diagnóstico histopatológico de Displasia leve


Oral Leucoplakia (OL) is a term used to describe predominantly white lesions of the oral mucous which cannot be characterized as other specific lesions and which have a potential for malignant transformation. OL is recognized as a lesion with the histopathological characteristics of epithelial dysplasia. The proportion of epithelial dysplasia (ED) which progress to spin cellular carcinomas varies within a range of 6.6 percent to 36 percent. The purpose of this study was to determine the relationship between ED of the oral mucous clinically diagnosed as Leucoplakia. To that end a total of 11,250 micro histories were reviewed, representing all the samples analized from October 1968 to December 1998. It was found that 180 of these cases reflected the pathology of interest. These data were analyzed according to their anatomical location, sex, age, ethnic group, and degree of epithelial dysplasia. 180 cases represented oral Leucoplakias with differing degrees of dysplasia, of which 97 (52.8 percent) were mild ED, 67 (37. 2 percent) were moderate ED and 18 (10 percent) were severed ED. The most frequent anatomical location reported in this study was the mucous of the alveolar ridge, with 42 cases (24. 1 percent). Next came and the cheek mucous, with 35 cases (19.2 percent). The leading age group was 50 - 59 years (30.2 percent) Females had a higher predisposition with 102 cases (56.4 percent). The Caucasian ethnic group was the most frequently affected, with 98 cases (53.8 percent). 43 percent of the patients were reported to be smokers. A clinical - pathological correlation of the cases reviewed in this study shows that Leucoplakia is most often related to histopathological diagnosis of mild dysplasia


Subject(s)
Middle Aged , Carcinoma, Papillary/diagnosis , Epithelial Cells/pathology , Dentin Dysplasia/diagnosis , Leukoplakia, Oral/diagnosis , Leukoplakia, Oral/pathology , Odontodysplasia/pathology
SELECTION OF CITATIONS
SEARCH DETAIL