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1.
Rev. bras. med. esporte ; 27(5): 464-467, July-Sept. 2021. tab, graf
Article in English | LILACS | ID: biblio-1288615

ABSTRACT

ABSTRACT Introduction: Immunity is closely related to health. When the body's immunity is strong, it is healthy. On the contrary, various diseases appear. Sports dance is an entertainment and fitness sports project that integrates sports, music, aesthetics, and dance, the body movement dance as the necessary content and two-person or collective exercises as the primary form of exercise. Studies have shown that long-term adherence to Tai Chi exercise can significantly increase the serum immunoglobulin IgA, IgG, and IgM levels. Objective: The paper explores the effect of physical dance exercise on serum immunoglobulin and T lymphocyte subsets of college students. Methods: The thesis randomly selected 16 male and female students in the first-grade physical dance optional course of public physical education as the experimental group. They performed physical dance exercises three times a week, 40 minutes each time, and the training intensity was controlled at a heart rate of 135-150 beats/min. Ten weeks; besides, 16 male and female students in the first grade were selected as the control group, and no physical dance exercise was performed; all the subjects were drawn from the elbow venous blood on an empty stomach at the same time before and after the experiment to measure serum immunoglobulin and T lymph Cell subpopulation content. Results: After ten weeks of sports dance training, the serum immunoglobulin IgG of both men and women in the experimental group increased significantly (P<0.01), and the CD4+% and CD4+/CD8+ ratio of T lymphocyte subgroups showed extremely significant and significant increases (P <0.01, P<0.05), serum IgM tended to increase, IgA, CD8+% tended to decrease, but there was no significant change. Conclusions: Long-term physical dance exercise can improve the body's immune function. Level of evidence II; Therapeutic studies - investigation of treatment results.


RESUMO Introdução: la inmunidad está estrechamente relacionado con la salud. Cuando la inmunidad del cuerpo es fuerte éste está sano. En caso contrario, aparecen diversas enfermedades. La danza deportiva é um projeto de entretenimiento y fitness que integra el deporte, la música, la estética y la danza, el movimiento corporal como contenido necesario y los ejercicios de das personas ou colectivos como forma principal de ejercicio. Los estudios han demonstraram que a adesão a largo plazo al ejercicio de Tai Chi pode aumentar também os niveles séricos de imunoglobulina IgA, IgG e IgM. Objetivo: O artigo explora o efeito do exercício físico de danza em subconjuntos de imunoglobulina sérica e linfocitos T de estudiantes universitários. Métodos: Para que a tese seja selecionada aleatoriamente, 16 ex-alunos e ex-alunos do curso optativo de danza física de primer grado de educação física pública como grupo experimental. Realizaron ejercicios de danza física tres veces por semana, 40 minutes cada vez, y la intensidad del entrenamiento se controló a una frecuencia cardíaca de 135-150 latidos/min. durante as semanas; además, se selecionar 16 alumnos y alumnas de primer grado como group de control, el que no realizó ningún ejercicio físico de danza. A todos os sujetos se les extrajo sangre venosa del codo com o estómago vacío, durante, antes e depois do experimento para medir o conteúdo da subpoblación de células T y de imunoglobulina sérica. Resultados: Después de diez semanas de entrenamiento de danza deportiva, la imunoglobulina IgG sérica de hombres y mujeres en el grupo experimental aumentó complementar (P <0,01), y la proporción CD4 +% y CD4 +/CD8 + de los subgrupos de linfocitos T mostró incrementos extremadamente provados. (P <0,01,P <0,05), la IgM sérica tendió a aumentar, la IgA, CD8 +% tendió a disminuir, mas nenhum hubo cambio projetado. Conclusiones: El ejercicio de danza física a largo plazo puede mejorar la función inmunológica del cuerpo. Nivel de evidencia II; Estudios terapéuticos: investigación de los results del tratamiento.


RESUMEN Introducción: la inmunidad está estrechamente relacionada con la salud. Cuando la inmunidad del cuerpo es fuerte éste está sano. En caso contrario, aparecen diversas enfermedades. La danza deportiva es un proyecto de entretenimiento y fitness que integra el deporte, la música, la estética y la danza, el movimiento corporal como contenido necesario y los ejercicios de dos personas o colectivos como forma principal de ejercicio. Los estudios han demostrado que la adherencia a largo plazo al ejercicio de Tai Chi puede aumentar significativamente los niveles séricos de inmunoglobulina IgA, IgG e IgM. Objetivo: El artículo explora el efecto del ejercicio físico de danza en subconjuntos de inmunoglobulina sérica y linfocitos T de estudiantes universitarios. Métodos: Para la tesis se seleccionaron aleatoriamente a 16 alumnos y alumnas del curso optativo de danza física de primer grado de educación física pública como grupo experimental. Realizaron ejercicios de danza física tres veces por semana, 40 minutos cada vez, y la intensidad del entrenamiento se controló a una frecuencia cardíaca de 135-150 latidos/min. durante diez semanas; además, se seleccionaron 16 alumnos y alumnas de primer grado como grupo de control, el que no realizó ningún ejercicio físico de danza. A todos los sujetos se les extrajo sangre venosa del codo con el estómago vacío, durante, antes y después del experimento para medir el contenido de la subpoblación de células T y de inmunoglobulina sérica. Resultados: Después de diez semanas de entrenamiento de danza deportiva, la inmunoglobulina IgG sérica de hombres y mujeres en el grupo experimental aumentó significativamente (P <0.01), y la proporción CD4 +% y CD4 + / CD8 + de los subgrupos de linfocitos T mostró incrementos extremadamente significativos. (P <0.01, P <0.05), la IgM sérica tendió a aumentar, la IgA, CD8 +% tendió a disminuir, pero no hubo cambios significativos. Conclusiones: El ejercicio de danza física a largo plazo puede mejorar la función inmunológica del cuerpo. Nivel de evidencia II; Estudios terapéuticos: investigación de los resultados del tratamiento.


Subject(s)
Humans , Male , Female , Adolescent , Young Adult , Universities , Immunoglobulins/blood , Dancing/physiology , Immunity/physiology , Student Health Services , Time Factors , Lymphocyte Count
2.
Rev. bras. med. esporte ; 27(3): 303-306, July-Sept. 2021. tab
Article in English | LILACS | ID: biblio-1288585

ABSTRACT

ABSTRACT Introduction According to the 2015 National Physical Health Monitoring Report, most of the national physical health indicators have begun to rebound, but some people's physical health is still declining. Object The thesis studies the problems existing in people's physical exercise and guides the development of these people's habits. Methods Our mathematical statistics and other research methods investigate the current situation of people's physical exercise habits, and explore the factors that restrict habits from the factors that affect the formation of sports and fitness concepts. Result The proportion of people developing physical exercise habits is low. People invest less time and energy in physical exercise. Conclusion The less time and energy that people invest in physical exercise is the main reason that affects their belief in exercise and fitness and physical exercise habits. Level of evidence II; Therapeutic studies - investigation of treatment results.


RESUMO Introdução De acordo com o Relatório Nacional de Monitoramento de Saúde Física de 2015, a maioria dos indicadores nacionais de saúde física começou a se recuperar, mas a saúde física de algumas pessoas ainda está em declínio. Objetivo a tese estuda os problemas existentes no exercício físico das pessoas e orienta o desenvolvimento dos hábitos dessas pessoas. Métodos Nossas estatísticas matemáticas e outros métodos de pesquisa investigam a situação atual dos hábitos de exercício físico das pessoas e exploram os fatores que restringem os hábitos e os fatores que afetam a formação de conceitos de esportes e preparação física. Resultado a proporção de pessoas que desenvolvem hábitos de exercícios físicos é baixa. As pessoas investem menos tempo e energia em exercícios físicos. Conclusão O pouco tempo e energia que as pessoas investem na prática de exercícios físicos é o principal motivo que afeta sua crença na prática de exercícios e hábitos de exercício físico. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.


RESUMEN Introducción De acuerdo con el Informe Nacional de Monitoreo de la Salud Física de 2015, la mayoría de los indicadores nacionales de salud física han comenzado a recuperarse, pero la salud física de algunas personas todavía está en declive. Objetivo la tesis estudia los problemas existentes en el ejercicio físico de las personas y orienta el desarrollo de los hábitos de estas personas. Métodos Nuestras estadísticas matemáticas y otros métodos de investigación investigan la situación actual de los hábitos de ejercicio físico de las personas y exploran los factores que restringen los hábitos y los factores que afectan la formación de conceptos deportivos y la preparación física. Resultado la proporción de personas que desarrollan hábitos de ejercicio físico es baja. La gente invierte menos tiempo y energía en el ejercicio físico. Conclusión El poco tiempo y energía que las personas invierten en la práctica de ejercicio físico es el principal motivo que incide en su creencia en la práctica de ejercicio y hábitos de ejercicio físico. Nivel de evidencia II; Estudios terapéuticos: investigación de los resultados del tratamiento.


Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Exercise/physiology , Healthy Lifestyle , Time Factors , Models, Statistical , Habits
3.
Arch. argent. pediatr ; 119(4): e315-e321, agosto 2021. tab
Article in English, Spanish | LILACS, BINACIS | ID: biblio-1281006

ABSTRACT

La prematiridad fue aumentando la supervivencia desde hace varios años, y eso produce, sobre todo, una preocupación en los prematuros nacidos antes de las 28 semanas de gestación. El tiempo del clampeo del cordón umbilical puede generar diversos trastornos, principalmente, cuando se realiza temprano (10-15 segundos). Ya desde hace 20 años, a través de varias investigaciones, se pudieron demostrar los notorios beneficios del clampeo demorado del cordón (de 2 a 3 minutos). Esta práctica fue instalada en la asistencia obstétrica y neonatal por las recomendaciones de sociedades científicas y de las revisiones sistemáticas, que señalaron las sólidas evidencias que apoyaban esta conducta para prematuros. En esta revisión, se describen los artículos más relevantes en los últimos años, que sustentan notoriamente la aplicación del clampeo demorado del cordón versus el clampeo temprano. Asimismo, esta práctica genera una disminución de los trastornos graves en prematuros.


For several years now, the survival of preterm infants has been increasing, which has shifted our concern to preterm infants born before 28 weeks of gestation in particular. The timing of umbilical cord clamping may lead to several disorders, especially when done early (10-15 seconds). In the last two decades, several investigations have shown the considerable benefits of delayed cord clamping (2-3 minutes). Delayed cord clamping has been practiced in obstetrics and neonatal care based on the recommendations made by scientific societies and in systematic reviews, which have provided solid evidence to support this practice in preterm infants. This review describes the most relevant articles from the last years, which strongly support the use of delayed cord clamping versus early cord clamping. In addition, this practice reduces the rate of severe disorders in preterm infants.


Subject(s)
Humans , Male , Female , Pregnancy , Infant, Newborn , Umbilical Cord , Placental Circulation/physiology , Ligation , Time Factors , Infant, Premature
4.
Arch. argent. pediatr ; 119(4): 270-273, agosto 2021. tab, ilus
Article in English, Spanish | LILACS, BINACIS | ID: biblio-1280932

ABSTRACT

En pacientes con infección por SARS-CoV-2 la intubación endotraqueal es un procedimiento con riesgo elevado de contagio. La videolaringoscopia complementa la protección del profesional, pero los videolaringoscopios comerciales son caros y no siempre están disponibles en las terapias intensivas pediátricas argentinas. El objetivo fue describir la práctica de intubación en un modelo de cabeza de simulación de lactante con un videolaringoscopio artesanal de bajo costo.Quince pediatras sin experiencia previa con el dispositivo participaron de una práctica de intubación en una cabeza de simulación con un videolaringoscopio artesanal. El tiempo promedio del primer intento fue de 116,4 segundos (intervalo de confianza del 95 % [IC95 %]: 84,8-148,0) y, el del siguiente fue de 44,2 segundos (IC95 %: 27,7­60,6). El tiempo disminuyó de forma significativa en el segundo intento (p : 0,0001). El dispositivo permitió la intubación exitosa en todos los intentos acortando la duración del procedimiento en la segunda práctica


In patients with SARS-CoV-2 infection, endotracheal intubation is a procedure with a high risk for transmission. A videolaryngoscopy is a supplementary level of health care provider protection, but commercial videolaryngoscopes are expensive and not always available in pediatric intensive care units in Argentina. Our objective was to describe intubation practice using an infant head mannequin with a low-cost, handcrafted videolaryngoscope.Fifteen pediatricians with no prior experience using the device participated in an intubation practice in a head mannequin with a handcrafted videolaryngoscope. The average time for the first attempt was 116.4 seconds (95 % confidence interval [CI]: 84.8-148.0) and, for the second one, 44.2 seconds (95 % CI: 27.7-60.6). Time decreased significantly for the second attempt (p: 0.0001).A successful intubation was achieved with the device in all attempts, and the procedure duration decreased with the second practice


Subject(s)
Humans , Infant , Pediatrics/education , Laryngoscopes/economics , Simulation Training/methods , COVID-19/prevention & control , Intubation, Intratracheal/instrumentation , Laryngoscopy/economics , Pediatrics/economics , Time Factors , Video Recording , Health Care Costs , Clinical Competence/statistics & numerical data , Education, Medical, Continuing/methods , Learning Curve , COVID-19/transmission , Internship and Residency/methods , Intubation, Intratracheal/economics , Intubation, Intratracheal/methods , Laryngoscopy/education , Laryngoscopy/instrumentation , Laryngoscopy/methods , Manikins
5.
Int. j. med. surg. sci. (Print) ; 8(2): 1-18, jun. 2021. ilus, tab
Article in English | LILACS | ID: biblio-1284462

ABSTRACT

Idiopathic retroperitoneal fibrosis is a rare fibro-inflammatory disease of varied etiology which usually originates around aorta and spreads caudally along Iliac vessels into adjacent retroperitoneum causing ureteral obstruction as the most frequent complication.A 53-year-old male patient presented with complaint of mild pain in both the legs off and on. On investigating further, we found that he had been struggling with intermittent relapses every 3-4 years for last 20 years since he was first diagnosed with Idiopathic Retroperitoneal Fibrosis. He was 33-year-old when he first developed the symptoms of anuria for 48 hours and was diagnosed with Idiopathic retroperitoneal fibrosis. This was followed by atrophy of left kidney and hypertension 6 years later, then hypothyroidism after another 3years and finally involvement of Inferior Vena Cava and acute Deep Vein Thrombosis of lower limbs after another 3-4 years. His deep vein thrombosis was well managed in time. He was put on glucocorticoids everytime he had a relapse and a complication.We did a review of literature to understand recent advances about its pathogenesis, diagnosis, investigations and management. We searched in PubMed using terms like retroperitoneal fibrosis alone and in combination with related terms such as Inferior Vena Cava thrombosis, Deep Vein Thrombosis, Tamoxifen, Methotrexate. This case is unique as it is very rare to find acute Deep Vein Thrombosis in Idiopathic retroperitoneal fibrosis without development of any collaterals when Inferior Vena Cava lumen is compromised to almost complete obstruction.After a follow up of 20 years patient is doing well in terms of physical activity and psychological wellbeing with anti-hypertensives, thyroxine and anti-coagulants. Is the disease-free interval actually free of the disease or it just subsided with immunosuppressants to become active after some time?


La fibrosis retroperitoneal idiopática es una enfermedad fibroinflamatoria rara, de etiología variada que generalmente se origina alrededor de la aorta y se propaga caudalmente a lo largo de los vasos ilíacos en retroperitoneo adyacente causando obstrucción ureteral como la complicación más frecuente.Reportamos el caso de un paciente varón de 53 años que se presentó con un dolor leve en ambas piernas. Al investigar más a fondo, descubrimos que había estado luchando con recaídas intermitentes cada 3-4 años durante los últimos 20 años desde que se le diagnosticó por primera vez fibrosis retroperitoneal idiopática. Tenía 33 años cuando desarrolló por primera vez los síntomas de anuria durante 48 horas y se le diagnosticó fibrosis retroperitoneal idiopática. Esto fue seguido por atrofia del riñón izquierdo e hipertensión 6 años después, luego hipotiroidismo después de otros 3 años y finalmente afectación de la vena cava inferior y trombosis venosa profunda aguda de las extremidades inferiores después de otros 3-4 años. Su trombosis venosa profunda se controló bien a tiempo. Le recetaron glucocorticoides cada vez que tenía una recaída y una complicación.Hicimos una revisión de la literatura para comprender los avances recientes sobre su patogenia, diagnóstico, investigaciones y manejo. Se realizaron búsquedas en PubMed utilizando términos como fibrosis retroperitoneal sola y en combinación con términos relacionados como trombosis de la vena cava inferior, trombosis venosa profunda, tamoxifeno, metotrexato. Este caso es único, ya que es muy raro encontrar trombosis venosa profunda aguda en fibrosis retroperitoneal idiopática sin desarrollo de colaterales cuando la luz de la vena cava inferior está comprometida hasta una obstrucción casi completa.Después de un seguimiento de 20 años, el paciente se encuentra bien en términos de actividad física y bienestar psicológico con antihipertensivos, tiroxina y anticoagulantes. ¿El intervalo libre de enfermedad está realmente libre de la enfermedad o simplemente disminuyó con inmunosupresores para activarse después de algún tiempo?


Subject(s)
Humans , Male , Middle Aged , Retroperitoneal Fibrosis/complications , Retroperitoneal Fibrosis/diagnosis , Retroperitoneal Fibrosis/therapy , Recurrence , Time Factors , Tomography, X-Ray Computed , Diagnosis, Differential , Hypothyroidism , Immunosuppressive Agents/therapeutic use
6.
Int. j. med. surg. sci. (Print) ; 8(2): 1-10, jun. 2021. tab
Article in Spanish | LILACS | ID: biblio-1284432

ABSTRACT

El orden y cronología del brote dentario temporal es una expresión del crecimiento del niño e influye en su posterior desarrollo dental y maxilofacial. Tener un conocimiento sobre la edad promedio de brote de cada diente es útil para establecer un diagnóstico, prevención y tratamiento de maloclusiones por lo cual el objetivo de esta investigación es caracterizar el patrón de brote de la dentición temporal en niños y niñas del municipio Cerro, La Habana, Cuba. Para ello se diseñó un estudio observacional descriptivo en 370 niños de ambos sexos entre 0 a 36 meses de edad, el estudio se desarrolló entre septiembre de 2017 a enero de 2020. Se estudiaron las variables: edad, sexo, diente, hemiarcada y cronología del brote dentario. Se realizaron distribuciones de frecuencia a todas las variables en estudio y se presentan los resultados en tablas estadísticas. Se utilizó la prueba t-Student para verificar las diferencias significativas. Los resultados principales obtenidos fueron que los dientes de maxilares brotaron antes que los mandibulares, a excepción de los incisivos centrales y el incisivo lateral inferior izquierdo. A pesar de que el brote dentario comenzó primero en individuos de sexo masculino en ambas arcadas (5,86 meses en el maxilar, ± 0,92; y en la mandíbula 4,92 meses ± 1,09), el período de tiempo de brote fue algo más rápido en el sexo femenino (19,83 meses en el maxilar y 21,64 meses en la mandíbula ) y los masculinos (20,26 meses y 22,16 meses), pero sin diferencias significativas (p<0,05). Se concluye que el patrón de brote fue similar al descrito en la literatura, excepto por discreto adelanto para los incisivos centrales y retraso en segundos molares temporales


The order and chronology of the temporary tooth eruption is an expression of the child's growth and influences his later dental development. Having knowledge about the average age of emergence of each tooth is useful to establish a diagnosis, prevention and treatment of malocclusions, for which the objective of this research is to characterize the pattern of emergence of primary dentition in children in Cerro district, Havana, Cuba. For this, a descriptive observational study was designed in 370 children of both sexes between 0 and 36 months of age, in said clinic during September / 2017 to January / 2020. The variables were studied: age, sex, tooth, hemiarcade and chronology of the dental outbreak. Frequency distributions were made to all the variables under study and the results are presented in statistical tables. The t-Student test was used to verify significant differences. The main results obtained were that the teeth of the maxillary arch erupted before those of the mandibular, except for the central incisors and the lower left lateral incisor. Although the fact that the dental flare began first in males in both arches (5,86 months in the maxilla, ± 0,92; and in the mandible 4,92 months ± 1,09), the time period of outbreak was somewhat faster in females (19,83 months in the maxilla and 21,64 months in the mandible) and males (20,26 months and 22,16 months), but without significant differences (p <0, 05). It is concluded that the eruption pattern was similar to that described in the literature, except for slight advancement for the central incisors and delay in second primary molars


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Tooth, Deciduous/growth & development , Time Factors , Prospective Studies , Sex Distribution , Age Distribution , Cuba , Dentition
7.
Int. j. med. surg. sci. (Print) ; 8(2): 1-10, jun. 2021. tab
Article in English | LILACS | ID: biblio-1284419

ABSTRACT

Introduction.Thyroid cancer is currently the first most common cancer in women in Ecuador. This study aimed to assess the changes in clinical presentation and diagnosis of differentiated thyroid cancer at a third level hospital in Quito, Ecuador.Methods and Materials.This is a retrospective case series performed in three consecutive periods from 1990 to 2019 at a tertiary level hospital, in Quito, Ecuador. The clinical records of 875 patients who had been diagnosed and surgically treated for differentiated thyroid cancer were reviewed. Demographic, clinical, imaging, and pathological data were collected and analyzed.Results. Significant trends toward older age, higher educational level, less palpable primary tumors, less palpable neck nodes, less distant metastases, more ultrasound, tomography and cytology exams, smaller primary tumors, more stage I patients, and more histological variant description, were found. Introduction.Thyroid cancer is currently the first most common cancer in women in Ecuador. This study aimed to assess the changes in clinical presentation and diagnosis of differentiated thyroid cancer at a third level hospital in Quito, Ecuador.Methods and Materials.This is a retrospective case series performed in three consecutive periods from 1990 to 2019 at a tertiary level hospital, in Quito, Ecuador. The clinical records of 875 patients who had been diagnosed and surgically treated for differentiated thyroid cancer were reviewed. Demographic, clinical, imaging, and pathological data were collected and analyzed.Results. Significant trends toward older age, higher educational level, less palpable primary tumors, less palpable neck nodes, less distant metastases, more ultrasound, tomography and cytology exams, smaller primary tumors, more stage I patients, and more histological variant description, were found.


Introducción. El cáncer de tiroides es actualmente el cáncer más frecuente en la mujer en Ecuador. El presente estudio ha tenido como objetivo evaluar los cambios en la presentación clínica y el diagnóstico del cáncer diferenciado de tiroides en un hospital de tercer nivel de Quito, Ecuador. Material y Métodos. El presente es un estudio retrospectivo de casos realizado en tres períodos consecutivos desde 1990 a 2019 en un hospital del tercer nivel en Quito, Ecuador. Los expedientes clínicos de 875 pacientes tratados quirúrgicamente por un cáncer diferenciado de tiroides fueron revisados. Los datos demográficos, clínicos, de imagen y patología fueron extraídos y analizados. Resultados. Se encontraron tendencias significativas hacia una edad más avanzada, nivel educativo más alto, menos tumores palpables, menos adenopatías regionales palpables, menos metástasis a distancia, más exámenes de ultrasonido y tomografía, más estudios de citología, más tumores pequeños y pacientes con estadío I y más descripciones de las variantes histológicas. Conclusiones. El cáncer de tiroides no sólo que ha aumentado continuamente en su frecuencia en los años recientes, sino que la presentación clínica, el manejo diagnóstico y terapéutico ha cambiado significativamente en las tres últimas décadas.


Subject(s)
Humans , Male , Female , Middle Aged , Thyroid Neoplasms/diagnosis , Thyroid Neoplasms/epidemiology , Time Factors , Thyroid Neoplasms/pathology , Clinical Evolution , Demography , Retrospective Studies , Self-Examination , Ecuador/epidemiology , Tertiary Care Centers
10.
Electron. j. biotechnol ; 51: 17-27, May. 2021. tab, ilus, graf
Article in English | LILACS | ID: biblio-1343317

ABSTRACT

BACKGROUND: In order to produce an effective callus in Echinacea purpurea L.; determination of the explant type and growth regulators that best respond to callus induction and the optimization of the culture conditions to increase the amount of caffeic acid derivatives (CADs) in the obtained callus. CADs contents of callus cultures of E. purpurea were evaluated by establishing an effective callus induction system in vitro. RESULTS: Various medium containing different growth regulators were tested using leaf, petiole, cotyledon and root as the explants. The best callus development was achieved in MS medium with 1.0 mg l 1 2,4- D + 2.0 mg l 1 BAP in leaf, 1.0 mg l 1 NAA + 0.5 mg l 1 TDZ in petiole, 2.0 mg l 1 NAA + 1.0 mg l 1 TDZ in cotyledon and 0.5 mg l 1 NAA + 0.5 mg l 1 BAP in roots. Upon optimisation of callus growth, each type of explant was cultured for 4, 6, 8 and 10 weeks in medium for the analyses of caftaric acid, chlorogenic acid, caffeic acid and chicoric acid contents. The highest amounts of caftaric acid (4.11 mg/g) and chicoric acid (57.89 mg/g) were found from petiole explants and chlorogenic acid (8.83 mg/g) from root explants at the end of the 10-week culture time. CONCLUSIONS: As a result of the present study, the production of caffeic acid derivatives was performed by providing the optimization of E. purpurea L. callus cultures. Effective and repeatable protocols established in this study may offer help for further studies investigating the production of caffeic acid derivatives in vitro.


Subject(s)
Caffeic Acids , Echinacea , Plant Growth Regulators , Time Factors , In Vitro Techniques , Cells, Cultured , Plant Roots/growth & development , Plant Leaves/growth & development , Cotyledon/growth & development , Culture Techniques
11.
Rev. polis psique ; 11(1): 5-26, jan.-abr. 2021. ilus
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1289909

ABSTRACT

A psicanálise muito se ocupou de compreender as sociedades e sujeitos que a compõem, e, disto, Freud desenvolveu as três estruturas clínicas. Contudo, foi com Lacan que a psicose foi mais explorada teórica e clinicamente. Depois, com Miller e a "formalização" do termo "psicose ordinária", em 1998, há também os "inclassificáveis", que escapam destas estruturas. Na sociologia, Bauman cria o termo "Modernidade Líquida", para se referir a este tempo de desbussolamento do sujeito, de escape e perda de referencial, que nos motivou a discutir, teoricamente, quais as relações entre essa modernidade e as estruturas psíquicas existentes e reconhecidas pela psicanálise Freud-lacaniana. Tal discussão foi realizada através de revisão bibliográfica das obras de Freud, Lacan, Miller e Bauman, resultando no entendimento de que as formas de gozo se multiplicaram e seu valor simbólico para o sujeito se estilhaçou; aquilo que era a regra, hoje é mais um dos desvios dos sintomas.


Psychoanalysis was very concerned with understanding the societies and subjects that compose it, and, from this, Freud developed the three clinical structures. However, However, with Lacan psychosis started to be more explored theoretically and clinically. Then, with Miller and the "formalization" of the term "ordinary psychosis", in 1998, there are also the "unclassifiable", who escape these structures. In sociology, Bauman coined the term "Liquid Modernity", to refer to this time of subject disbussing, of escape and loss of reference, which motivated us to discuss, theoretically, which relationships are between this modernity and the existing psychic structures and recognized by Freud-Lacanian psychoanalysis. Carried out through a bibliographic review from Freud, Lacan, Miller and Bauman's work, which results in the, resulting in the understanding that the forms of jouissance multiplied and their symbolic value for the subject shattered; what used to be the rule, today is yet another symptom deviation.


El psicoanálisis se preocupó mucho por comprender las sociedades y los sujetos que lo componen y, a partir de ello, Freud desarrolló las tres estructuras clínicas. Sin embargo, fue con Lacan que la psicosis se exploró más teórica y clínicamente. Luego, con Miller y la "formalización" del término "psicosis ordinaria", en 1998, también están los "inclasificables", que escapan a estas estructuras. En sociología, Bauman acuñó el término "Modernidad líquida", para referirse a este tiempo de discusión de sujetos, de escape y pérdida de referencia, que nos motivó a discutir, teóricamente, cuáles son las relaciones entre esta modernidad y las estructuras psíquicas existentes y reconocido por el psicoanálisis freud-lacaniano. Dicha discusión se llevó a cabo mediante una revisión bibliográfica de las obras de Freud, Lacan, Miller y Bauman, dando como resultado la comprensión de que las formas de goce se multiplicaron y su valor simbólico para el sujeto se hizo añicos; lo que solía ser la regla, hoy es otra desviación de síntoma.


Subject(s)
Psychoanalysis , Sociology , Psychotic Disorders/history , Time Factors
12.
Rev. bras. med. esporte ; 27(spe): 37-39, Mar. 2021. tab
Article in English | LILACS | ID: biblio-1156122

ABSTRACT

ABSTRACT As a common metabolic disease, non-alcoholic fatty liver disease (NAFLD) is the most common type of liver disease in western developed countries and an important liver disease in the Asia Pacific region. At present, NAFLD lacks targeted conventional therapy and its basic treatment is the correction of bad living habits. In order to verify the effectiveness of the basic treatment of NAFLD, and explore the prevention methods of NAFLD, this study used ultrasound diagnosis, baseline survey and follow-up survey, and conducted a cross-sectional study on the correlation between nighttime and midday sleep duration and NAFLD, and carried out a prospective study on the correlation between sleep duration and NAFLD. The results showed that there was a negative correlation between the length of sleep at night and the prevalence of NAFLD, while the length of midday sleep was positively correlated with the prevalence of NAFLD. The time of night sleep was an independent factor of NAFLD, and the relationship between midday sleep time and NAFLD was not statistically significant. NAFLD-susceptible people can prevent NAFLD by ensuring adequate sleep at night and reducing midday sleep. This study is expected to provide theoretical reference and data support for the prevention and treatment of NAFLD.


RESUMO Como uma doença metabólica comum, a doença doença hepática gordurosa não alcoólica (DHGNA) é o tipo de doença hepática mais comum nos países desenvolvidos ocidentais e uma doença hepática importante na região Ásia Pacífico. Atualmente, a DHGNA carece de terapia convencional orientada, e seu tratamento básico é a correção de maus hábitos de vida. A fim de verificar a eficácia do tratamento básico da DHGNA e explorar os métodos de prevenção da DHGNA, este estudo, baseado no diagnóstico por ultrassom, através do inquérito de base e do inquérito de acompanhamento, consistiu de estudo transversal sobre a correlação entre a duração do sono à noite e de dia e a DHGNA, e realizou um estudo prospectivo sobre a correlação entre a duração do sono e a DHGNA. Os resultados mostraram que havia uma correlação negativa entre a duração do sono à noite e a prevalência de DHGNA, enquanto a duração do sono de dia estava positivamente correlacionada com a prevalência da DHGNA. A hora do sono noturno foi um fator independente de DHGNA, e a relação entre o sono de dia e DHGNA não foi estatisticamente significativa. As pessoas sensíveis à DHGNA podem prevenir a DHGNA garantindo o sono adequado à noite e reduzindo o sono de dia. Espera-se que este estudo possa fornecer referências teóricas e suporte de dados para a prevenção e tratamento da DHGNA.


RESUMEN Como enfermedad metabólica común, la enfermedad del hígado graso no alcohólico (NAFLD) es el tipo más común de enfermedad hepática en los países desarrollados occidentales y una enfermedad hepática importante en la región de Asia que da al Pacífico. En la actualidad, la EHGNA carece de terapia convencional dirigida y su tratamiento básico es la corrección de los malos hábitos de vida. Con el fin de verificar la efectividad del tratamiento básico y explorar los métodos de prevención de la EHGNA, este estudio utilizó un diagnóstico por ultrasonido, una encuesta de referencia y una encuesta de seguimiento, condujo un estudio transversal sobre la correlación entre la duración del sueño nocturno y la siesta y la EHGNA, y realizó un estudio prospectivo sobre la correlación entre la duración del sueño y la EHGNA. Los resultados mostraron que hubo una correlación negativa entre la duración del sueño por la noche y la prevalencia de EHGNA, mientras que la duración de la siesta se correlacionó positivamente con la prevalencia de EHGNA. El tiempo de sueño nocturno fue un factor independiente de la EHGNA, y la relación entre el tiempo de siesta y la EHGNA no fue estadísticamente significativa. Las personas susceptibles a la EHGNA pueden prevenirla asegurando un sueño adecuado por la noche y reduciendo la siesta. Se espera que este estudio proporcione referencias teóricas y soporte de datos para la prevención y el tratamiento de la EHGNA.


Subject(s)
Humans , Middle Aged , Non-alcoholic Fatty Liver Disease/diagnostic imaging , Sleep Hygiene , Time Factors , Cross-Sectional Studies , Prospective Studies , Non-alcoholic Fatty Liver Disease/prevention & control
13.
Arch. argent. pediatr ; 119(1): 18-24, feb. 2021. tab, ilus
Article in English, Spanish | LILACS, BINACIS | ID: biblio-1147062

ABSTRACT

Introducción. A nivel mundial, hay una tendencia ascendente en nacimientos prematuros y cesáreas. El objetivo fue describir edad gestacional (EG), vía de parto, distribución en días y horarios, y relación entre la vía de parto y el momento del nacimiento en dos instituciones privadas.Población y métodos. Estudio prospectivo, transversal, analítico.Resultados. Se incluyeron los 1500 nacidos vivos entre 9-2017 y 8-2018 (1465 embarazadas). El 99,4 % fueron embarazos controlados; el 66,8 % terminaron por cesárea. La causa fue cesárea previa en el 36,4 %, falta de progresión y descenso en el 18,9 % y elección materna en el 9,2 %. El peso promedio al nacer fue de 3232 g ± 561,1 g y la mediana de EG, 39 semanas (rango 38-40) por fecha de última menstruación. El 88,2 % fueron nacidos de término y, de los prematuros, el 76,1 % fueron pretérminos tardíos. Los nacidos de término temprano tuvieron mayor índice de cesáreas (p < 0,001). Los nacimientos por cesárea en días hábiles fueron 849/1201 (el 74,5 %) y, en los días de fin de semana y feriados, 173/299 (el 57,9 %, p < 0,001). Se encontró una relación estadísticamente significativa entre el horario de nacimiento y la realización de cesárea.Conclusiones. La mediana de EG fue 39 semanas. La cesárea fue la vía de nacimiento más frecuente. Los nacimientos se produjeron, predominantemente, de lunes a viernes entre las 8 y las 21 h. El 82,9 % de los nacimientos por cesárea ocurrieron en días de semana laborables


Introduction. There is a worldwide growing trend of preterm births and C-sections. Our objective was to describe gestational age (GA), mode of delivery, day and time distribution, and the relation between the mode of delivery and the time of birth in two private facilities.Population and methods. Prospective, cross-sectional, analytical study.Results. A total of 1500 live newborn infants were included between September 2017 and August 2018 (1465 pregnant women). Of these, 99.4 % had received antenatal care; 66.8 % of pregnancies ended via C-section. The reason was a previous C-section in 36.4 %, lack of progression and descent in 18.9 %, and maternal choice in 9.2 %. The average birth weight was 3232 g ± 561.1 g and the median GA was 39 weeks (range: 38-40) based on the date of the last menstrual period; 88.2 % were term births and, among preterm births, 76.1 % corresponded to late preterm babies. Early term births showed a higher rate of C-sections (p < 0.001). There were 849/1201 (74.5 %) C-sections on weekdays and 173/299 (57.9 %, p < 0.001) on weekends and holidays. A statistically significant relation was observed between the time of birth and the performance of a C-section.Conclusions. The median GA was 39 weeks. C-sections were the most common mode of delivery. Births occurred predominantly Mondays through Fridays between 8 a.m. and 9 p.m.; 82.9 % of C-sections took place on weekdays.


Subject(s)
Humans , Male , Female , Pregnancy , Infant, Newborn , Cesarean Section , Gestational Age , Time Factors , Infant, Premature , Cross-Sectional Studies , Prospective Studies , Parturition
14.
Rev. bras. cir. cardiovasc ; 36(1): 32-38, Jan.-Feb. 2021. tab, graf
Article in English | LILACS | ID: biblio-1155805

ABSTRACT

Abstract Introduction: The delayed extubation of patients undergoing mechanical ventilation (MV) in the postoperative period of cardiac surgery (CS) is associated with mortality. The adoption of spinal anesthesia (SA) combined with general anesthesia in CS influences the orotracheal intubation time (OIT). This study aims to verify if the adoption of SA reduces the time of MV after CS, compared to general anesthesia (GA) alone. Methods: Two hundred and seventeen CS patients were divided into two groups. The GA group included 108 patients (age: 56±1 years, 66 males) and the SA group included 109 patients (age: 60±13 years, 55 males). Patients were weaned from MV and, after clinical evaluation, extubated. Results: In the SA group, considering a 13-month period, 24% of the patients were extubated in the operating room (OR), compared to 10% in the GA group (P=0.00). The OIT was lower in the SA group than in the GA group (SA: 4.4±5.9 hours vs. GA: 6.0±5.6 hours, P=0.04). In July/2017, where all surgeries were performed in the GA regimen, only 7.1% of the patients were extubated in the OR. In July/2018, 94% of the surgeries were performed under SA, and 64.7% of the patients were extubated in the OR (P=0.00). The OIT on arrival at the intensive care unit to extubation, comparing July/2017 to July/2018, was 5.3±5.3 hours in the GA group vs. 1.7±3.9 hours in the SA group (P=0.04). Conclusion: The adoption of SA in CS increased the frequency of extubations in the OR and decreased OIT and MV time.


Subject(s)
Humans , Male , Middle Aged , Aged , Cardiac Surgical Procedures , Anesthesia, Spinal , Operating Rooms , Respiration, Artificial , Time Factors , Retrospective Studies , Airway Extubation
15.
Rev. bras. med. esporte ; 27(1): 108-112, Jan.-Mar. 2021. tab, graf
Article in English | LILACS | ID: biblio-1156102

ABSTRACT

ABSTRACT Introduction There are few studies on the effectiveness of training models with high volume sets per session in particular muscle groups. Objective The aim of the study was to investigate the effects of different resistance training (RT) repetitions with equalized volumes on muscle adaptations. Methods This study used an experimental design in which forty-seven volunteers underwent 8 weeks of RT after having been distributed randomly into three groups: ten sets of three maximum repetitions (10x3), three sets of ten maximum repetitions (3x10) and five sets of six maximum repetitions (5x6) for each muscular group per training session. Maximum strength (1RM test) and muscle thickness (MT) were evaluated as outcomes. Results A significant main effect (p=0.001) of time on maximum strength was observed for the three groups, but no significance was observed (p>0.05) in time x group interactions. A significant main effect (p=0.001) of time was observed on MT for biceps, triceps and vastus lateralis, without significant differences for time x group interactions. Significant correlations were found between maximum strength and muscle thickness after general statistical analyses for all protocols. Conclusion Improvements in maximum strength and muscle thickness are similar when repetition volumes are equalized through the number of series and repetitions. Level of evidence I; Therapeutic studies, investigation of treatment results.


RESUMO Introdução Existem poucos estudos sobre a eficácia de modelos de treinamento com conjuntos de alto volume por sessão em grupos musculares específicos. Objetivos O objetivo do estudo foi investigar os efeitos de diferentes repetições do treinamento de resistência (TR) com volumes equalizados nas adaptações musculares. Métodos Este estudo tem desenho experimental com 47 voluntários que realizaram oito semanas de TR depois de serem distribuídos randomicamente em três grupos: dez séries de três repetições máximas (10x3), três séries de dez repetições máximas (3x10) e cinco séries de seis repetições máximas (5x6) para cada grupo muscular por sessão de treinamento. A força máxima (teste de 1RM) e a espessura muscular (EM) foram avaliadas como desfecho. Resultados Verificou-se efeito significativo (p = 0,001) sobre o tempo na força máxima nos três grupos, contudo, nenhuma significância (p > 0,05) foi observada nas interações entre tempo e grupo. Constatou-se efeito significativo (p = 0,001) do tempo sobre a EM para bíceps, tríceps e vasto lateral, sem diferenças significativas nas interações entre tempo e grupo. Correlações significativas foram encontradas entre força máxima e espessura muscular depois das análises estatísticas gerais para todos os protocolos. Conclusões A melhora da força máxima e da espessura muscular é semelhante quando o volume de repetições é equalizado considerando o número de séries e repetições. Nível de evidência I; Estudos terapêuticos, investigação dos resultados do tratamento.


RESUMEN Introducción Existen pocos estudios sobre la eficacia de modelos entrenamiento con conjuntos de alto volumen por sesión en grupos musculares específicos. Objetivos El objetivo del estudio fue investigar los efectos de diferentes repeticiones del entrenamiento de resistencia (ER) con volúmenes ecualizados en las adaptaciones musculares. Métodos Este estudio tiene diseño experimental con 47 voluntarios que realizaron ocho semanas de ER después de ser distribuidos aleatoriamente en tres grupos: diez series de tres repeticiones máximas (10x3), tres series de diez repeticiones máximas (3x10) y cinco series de seis repeticiones máximas (5x6) para cada grupo muscular por sesión de entrenamiento. La fuerza máxima (test de 1RM) y el espesor muscular (EM) fueron evaluados como conclusión. Resultados Se verificó efecto significativo (p = 0,001) sobre el tiempo en la fuerza máxima en los tres grupos, sin embargo, ninguna significancia (p> 0,05) fue observada en las interacciones entre tiempo y grupo. Se constató efecto significativo (p = 0,001) del tiempo sobre el EM para bíceps, tríceps y vasto lateral, sin diferencias significativas en las interacciones entre tiempo y grupo. Fueron encontradas correlaciones significativas entre fuerza máxima y espesor muscular después de los análisis estadísticos generales para todos los protocolos. Conclusiones La mejora de la fuerza máxima y del espesor muscular es semejante cuando el volumen de repeticiones es ecualizado considerando el número de series y repeticiones. Nivel de evidencia I; Estudios terapéuticos, investigación de los resultados del tratamiento.


Subject(s)
Humans , Adult , Young Adult , Exercise/physiology , Resistance Training/methods , Muscles/physiology , Time Factors
16.
Chinese Medical Journal ; (24): 927-934, 2021.
Article in English | WPRIM | ID: wpr-878141

ABSTRACT

BACKGROUND@#Acute type A aortic dissection (ATAAD) and acute type A intramural hematoma (ATAIMH) are life-threatening diseases with high mortality. To better understand their clinical features in the Chinese population, we analyzed the data from the first Registry of Aortic Dissection in China (Sino-RAD) to promote the understanding and management of the diseases.@*METHODS@#All patients with ATAAD and ATAIMH enrolled in Sino-RAD from January 1, 2012 to December 31, 2016 were involved. The data of patients' selection, history, symptoms, management, outcomes, and postoperation complications were analyzed in the study. The continuous variables were compared using the Student's t test for normal distributions and the Mann-Whitney U test for non-normal distributions. Categorical variables were compared using the Chi-square test or Fisher exact test.@*RESULTS@#A total of 1582 patients with ATAAD and 130 patients with ATAIMH were included. The mean age of all patients was 48.4 years. Patients with ATAAD were significantly younger than patients with ATAIMH (48.9 years vs. 55.6 years, P < 0.001). For the total cohort, males were dominant, but the male ratio of patients with ATAAD was significantly higher compared to those with ATAIMH (P = 0.01). The time range from the onset of symptom to hospitalization was 2.0 days. More patients of ATAIMH had hypertension than that of ATAAD (82.3% vs. 67.6%, P < 0.05). Chest and back pain were the most common clinical symptoms. Computerized tomography (CT) was the most common initial diagnostic imaging modality. 84.7% received surgical treatment and in-hospital mortality was 5.3%. Patients with ATAAD mainly received surgical treatment (89.6%), while most patients with ATAIMH received medical treatment (39.2%) or endovascular repair (35.4%).@*CONCLUSIONS@#Our study suggests that doctors should comprehensively use clinical examination and genetic background screening for patients with ATAAD and ATAIMH and further shorten the time range from symptoms onset to intervention, achieving early diagnosis and treatment, thereby reducing the mortality rate of patients with aortic dissection in China. We should standardize the procedures of aortic dissection treatment and improve people's understanding. Meanwhile, the curing and transferring efficiency should also be improved.


Subject(s)
Acute Disease , Aneurysm, Dissecting/diagnosis , China , Hematoma , Humans , Male , Middle Aged , Registries , Retrospective Studies , Time Factors , Treatment Outcome
17.
Chinese Medical Journal ; (24): 524-531, 2021.
Article in English | WPRIM | ID: wpr-878080

ABSTRACT

BACKGROUND@#Reduced application of percutaneous coronary intervention (PCI) is associated with higher mortality rates after ST-segment elevation myocardial infarction (STEMI). We aimed to evaluate potential factors contributing to the refusal of PCI in STEMI patients in China.@*METHODS@#We studied 957 patients diagnosed with STEMI in the emergency departments (EDs) of six public hospitals in China. The differences in baseline characteristics and 30-day outcome were investigated between patients who refused PCI and those who underwent PCI. Multivariable logistic regression was used to evaluate the potential factors associated with refusing PCI.@*RESULTS@#The potential factors contributing to refusing PCI were older than 65 years (odds ratio [OR] 2.66, 95% confidence interval [CI] 1.56-4.52, P 12 h) (OR 3.31, 95% CI 1.83-6.02, P < 0.001) and not being hospitalized in a tertiary hospital (OR 0.45, 95% CI 0.27-0.75, P = 0.002). Compared to men, women were older, were less often married, had a lower BMI and were less often hospitalized in tertiary hospitals.@*CONCLUSIONS@#Patients who were older, had lower economic or social status, and had poorer health status were more likely to refuse PCI after STEMI. There was a sex difference in the potential predictors of refusing PCI. Targeted efforts should be made to improve the acceptance of PCI among patients with STEMI in China.


Subject(s)
China , Female , Humans , Male , Myocardial Infarction , Percutaneous Coronary Intervention , Risk Factors , ST Elevation Myocardial Infarction/surgery , Time Factors , Treatment Outcome
18.
Article in Chinese | WPRIM | ID: wpr-877615

ABSTRACT

"Treatment in accordance with time factor" is one of the key principles of acupuncture and moxibustion treatment. In clinical practice of acupuncture and moxibustion, the connotation of "timing/time factor" should be fully understood and the temporal rule on physiology and pathology affected by the changes of four seasons and day and night be grasped. Based on the change law of


Subject(s)
Acupuncture Points , Acupuncture Therapy , Moxibustion , Needles , Time Factors
19.
Braz. j. med. biol. res ; 54(1): e10115, 2021. tab, graf
Article in English | LILACS, ColecionaSUS | ID: biblio-1132561

ABSTRACT

The introduction of early complementary feeding (ECF) is determined by different factors depending on when it occurs. The objective of this study was to analyze factors associated with the introduction of ECF in two different moments of the infant's life: from zero to three and from four to five months of age. A cohort with 3,306 dyads studied in the BRISA survey in São Luis/MA in 2010 was used. Questionnaires were applied at birth and at follow-up when the infants were 15 to 36 months of age of women with more than 20 weeks of gestational age, residing in this municipality. A multivariate model of multinomial logistic regression was used to verify associations between independent variables and ECF at 0 to 3 months and at 4 to 5 months of age. A hierarchical analysis model was used to select variables for confounding adjustment. Variables with a P-value <0.05 were considered significant. For ECF introduced between 0-3 months, the variables "use of pacifier", "maternal paid activity", "smoking", and "postpartum pregnancy" were identified as risk factors. The variables "use of pacifier" and "maternal paid activity" remained associated as a risk for ECF introduced from 4-5 months. The variable 'mother without partner' (RR=1.26 and P=0.04) represented a risk factor for ECF only for the 4-5 months period. Although each period presented specific risk factors, the use of pacifier and maternal professional activity were associated in the two periods studied, indicating their importance for the introduction of ECF.


Subject(s)
Humans , Female , Pregnancy , Infant , Adult , Young Adult , Infant Nutritional Physiological Phenomena , Time Factors , Brazil , Breast Feeding , Smoking , Cesarean Section , Risk Factors , Cohort Studies , Gestational Age , Pacifiers , Employment
20.
Cad. Saúde Pública (Online) ; 37(10): e00293220, 2021. tab
Article in Portuguese | LILACS | ID: biblio-1345617

ABSTRACT

O estudo buscou investigar se o tempo máximo de demora (60 dias) para o início do tratamento dos pacientes com câncer de boca a partir do diagnóstico, previsto na Lei Federal nº 12.732/2012, foi alcançado no Brasil no período de 2013-2019 e descrever a tendência do número de casos que iniciaram o tratamento no tempo máximo. Realizou-se um estudo de séries temporais utilizando dados dos tratamentos (N = 37.417) do Painel-Oncologia, disponível no Departamento de Informática do SUS (DATASUS), segundo região de residência dos pacientes. Para análise da tendência executou-se a regressão de Prais-Winsten. Nos anos 2018 e 2019 foram observados percentuais mais elevados para os tratamentos em até 60 dias, sendo mais acentuado no intervalo de até 30 dias. Em 2019, 61,5% dos tratamentos iniciaram em até 60 dias, com maiores proporções nas regiões Sul (71,3%), Sudeste (60,1%) e Centro-oeste (59,1%). A tendência temporal da categoria 0-60 dias foi crescente na Região Norte, com variação percentual anual (VPA) de 15,7% e estacionária nas demais regiões e para o Brasil. A tendência do tempo de 0-30 dias foi crescente apenas para as regiões Norte e Nordeste, com VPA de 29,75% e 20,56%, respectivamente. Conclui-se que a partir de 2018 houve um maior número de casos que iniciaram o tratamento do câncer de boca no tempo de demora, conforme previsto na Lei nº 12.732/2012 (até 60 dias), com diferenças regionais e tendência estacionária na maioria das regiões e no Brasil. O alcance parcial da meta, o predomínio da tendência estacionária e as desigualdades regionais indicam a necessidade de continuar monitorando o tempo de demora para o início do tratamento do câncer no país e intensificar esforços para garantir o cuidado em saúde.


The study aimed to investigate whether the maximum delay (60 days) for initiating oral cancer treatment following diagnosis, as provided in Federal Law n. 12,732/2012, was achieved in Brazil from 2013 to 2019 and to describe the trend in the number of cases that initiated treatment within this timeframe. A time series was performed with treatment data (N = 37,417) from the Oncology Dashboard of the Brazilian Health Informatics Department (DATASUS) database, according to the patient's region of residence. Analysis of trend used Prais-Winsten regression. In 2018 and 2019, we observed higher percentages of treatments within 60 days, and especially within 30 days. In 2019, 61.5% of treatments began within 60 days, with the highest proportions in the South (71.3%), Southeast (60.1%), and Central-west (59.1%) regions of Brazil. The time trend for the category from 0-60 days was upward in the North of Brazil, with 15.7% annual percent change (APC), and was stationary in the other four major geographic regions of Brazil. The time trend for 0-30 days was only upward in the North and Northeast, with APCs of 29.75% and 20.56%, respectively. In conclusion, since 2018 there were more cases that initiated oral cancer treatment within the stipulated timeframe, as provided in Law n. 12,732/2012 (up to 60 days), with regional differences and a stationary trend in most regions and in Brazil as a whole. Partial achievement of the target, the predominance of a stationary trend, and regional inequalities indicate the need to continue monitoring time-to-treatment for oral cancer in Brazil and to intensify efforts to guarantee timely healthcare.


El estudio tuvo como meta investigar si el tiempo máximo de demora (60 días) para el inicio del tratamiento de los pacientes con cáncer de boca, a partir del diagnóstico previsto en la Ley Federal nº 12.732/2012, se alcanzó en Brasil durante el período 2013-2019, y describir la tendencia del número de casos que comenzaron el tratamiento en el tiempo máximo. Se realizó un estudio de series temporales utilizando datos de los tratamientos (N = 37.417) del Panel-oncología, disponible en Departamento de Informática del Sistema Único de Salud (DATASUS), según la región de residencia de los pacientes. Para el análisis de la tendencia se realizó la regresión de Prais-Winsten. En los años 2018 y 2019 se observaron porcentajes más elevados para los tratamientos en hasta 60 días, siendo más acentuado en el intervalo de hasta 30 días. En 2019, un 61,5% de los tratamientos comenzaron en hasta 60 días, con mayores proporciones en las regiones Sur (71,3%), Sudeste (60,1%) y Centro-oeste (59,1%). La tendencia temporal de la categoría 0-60 días fue creciente en la Región Norte, con variación porcentaje anual (VPA) de un 15,7% y estacionaria en las demás regiones y en Brasil. La tendencia del tiempo de 0-30 días fue creciente solamente para las regiones Norte y Nordeste, con VPA de 29,75% y 20,56%, respectivamente. Se concluye que a partir de 2018 hubo un mayor número de casos que comenzaron el tratamiento de cáncer de boca durante el tiempo de demora, conforme lo previsto en la Ley nº 12.732/2012 (hasta 60 días), con diferencias regionales y tendencia estacionaria en la mayoría de las regiones y en Brasil. El alcance parcial de la meta, el predominio de la tendencia estacionaria y las desigualdades regionales indican la necesidad de continuar supervisando el tiempo de demora para el inicio del tratamiento de cáncer en el país e intensificar esfuerzos para garantizar el cuidado en salud.


Subject(s)
Humans , Mouth Neoplasms/drug therapy , Delivery of Health Care , Time Factors , Brazil
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