Search details
1.
Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers.
J Med Chem
; 66(23): 15629-15647, 2023 12 14.
Article
in English
| MEDLINE | ID: mdl-37967851
2.
MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.
Antimicrob Agents Chemother
; 56(8): 4161-7, 2012 Aug.
Article
in English
| MEDLINE | ID: mdl-22615282
3.
Discovery of pyrrolidine-based ß-secretase inhibitors: lead advancement through conformational design for maintenance of ligand binding efficiency.
Bioorg Med Chem Lett
; 22(1): 240-4, 2012 Jan 01.
Article
in English
| MEDLINE | ID: mdl-22130130
4.
Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain L-2-hydroxy acid oxidase.
Bioorg Med Chem Lett
; 22(13): 4341-7, 2012 Jul 01.
Article
in English
| MEDLINE | ID: mdl-22658862
5.
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
Bioorg Med Chem Lett
; 22(12): 3941-5, 2012 Jun 15.
Article
in English
| MEDLINE | ID: mdl-22607672
6.
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
Bioorg Med Chem Lett
; 22(23): 7207-13, 2012 Dec 01.
Article
in English
| MEDLINE | ID: mdl-23084906
7.
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease.
Bioorg Med Chem Lett
; 22(23): 7201-6, 2012 Dec 01.
Article
in English
| MEDLINE | ID: mdl-23021993
8.
Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors.
J Neurochem
; 118(6): 1016-31, 2011 Sep.
Article
in English
| MEDLINE | ID: mdl-21736568
9.
Identification of a novel RAMP-independent CGRP receptor antagonist.
Bioorg Med Chem Lett
; 21(22): 6705-8, 2011 Nov 15.
Article
in English
| MEDLINE | ID: mdl-21982500
10.
Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: discovery of MK-2918.
Bioorg Med Chem Lett
; 21(9): 2683-6, 2011 May 01.
Article
in English
| MEDLINE | ID: mdl-21251825
11.
MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease.
Antimicrob Agents Chemother
; 54(1): 305-11, 2010 Jan.
Article
in English
| MEDLINE | ID: mdl-19841155
12.
Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist.
J Pharmacol Exp Ther
; 333(1): 152-60, 2010 Apr.
Article
in English
| MEDLINE | ID: mdl-20065019
13.
Epsilon substituted lysinol derivatives as HIV-1 protease inhibitors.
Bioorg Med Chem Lett
; 20(14): 4065-8, 2010 Jul 15.
Article
in English
| MEDLINE | ID: mdl-20547452
14.
Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality.
Bioorg Med Chem Lett
; 20(22): 6827-30, 2010 Nov 15.
Article
in English
| MEDLINE | ID: mdl-20850973
15.
Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors.
Bioorg Med Chem Lett
; 20(5): 1779-82, 2010 Mar 01.
Article
in English
| MEDLINE | ID: mdl-20122828
16.
Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold.
Bioorg Med Chem Lett
; 20(22): 6754-7, 2010 Nov 15.
Article
in English
| MEDLINE | ID: mdl-20869872
17.
Identification of potent, highly constrained CGRP receptor antagonists.
Bioorg Med Chem Lett
; 20(8): 2572-6, 2010 Apr 15.
Article
in English
| MEDLINE | ID: mdl-20299218
18.
SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.
Bioorg Med Chem Lett
; 20(6): 1885-9, 2010 Mar 15.
Article
in English
| MEDLINE | ID: mdl-20176482
19.
First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
J Pharmacol Exp Ther
; 328(1): 131-40, 2009 Jan.
Article
in English
| MEDLINE | ID: mdl-18854490
20.
Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines.
Bioorg Med Chem Lett
; 19(22): 6368-72, 2009 Nov 15.
Article
in English
| MEDLINE | ID: mdl-19818613