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Cell Rep Methods
; 2(12): 100353, 2022 12 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-36590695
RESUMEN
We describe a mouse model of rectal cancer (RC) involving rapid tumor organoid engraftment via orthotopic transplantation in an immunocompetent setting. This approach uses simple mechanical disruption to allow engraftment, avoiding the use of dextran sulfate sodium. The resulting RC tumors invaded from the mucosal surface and metastasized to distant organs. Histologically, the tumors closely resemble human RC and mirror remodeling of the tumor microenvironment in response to radiation. This murine RC model thus recapitulates key aspects of human RC pathogenesis and presents an accessible approach for more physiologically accurate, preclinical efficacy studies.
Asunto(s)
Neoplasias del Recto , Ratones , Humanos , Animales , Neoplasias del Recto/radioterapia , Microambiente Tumoral
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