Towards the revival of oscillation from complete cessation in stochastic systems for application in molecular biology.

Delay and noise are inevitable in complex systems that are common in biochemical networks. The system is often disturbed at various states irrespective of the size (small or large) of delay and noise. Therefore, it is of interest to describe the significance of delay and noise in stochastic Willamowski-Rossler chemical oscillator model using a delay stochastic (having random probability distribution) simulation algorithm. Oscillating dynamics moves to stable fixed point when delay at a fixed magnitude of noise drives the system from oscillating state to stochastic amplitude death state (complete cessation). However, the amplitude death state is induced to a revived oscillating state in stochastic system (which is far from equilibrium state) for noise with a fixed value of delay. Thus, significantly large and small noise induces the dynamics of the system to amplitude death state. Hence, we describe the interplay of delay and noise in stochastic systems for the proper and efficient functioning of the complex system that are frequent in biological networks.

Prevalence of rheumatic heart disease in school-going children of Eastern Uttar Pradesh.

BACKGROUND: Rheumatic heart disease is a major health problem in our country. There is evidence from South India that its prevalence is declining. This study attempts to confirm whether this is so in North India as well. METHODS AND RESULTS: A total of 118,212 (68,357 males, 49,855 females) schoolchildren in the age group of 4-18 years were examined for the presence of heart disease. Evaluation, including echocardiography, confirmed that of a total of 389 suspected to have heart disease, 61 had rheumatic heart disease. Thus, the prevalence of rheumatic heart disease was found to be approximately 0.5 per 1000 children. CONCLUSION: In a fairly large school survey conducted by us, the prevalence of rheumatic heart disease turned out to be approximately 0.5 per 1000 children. This is the lowest figure reported from our country so far and confirms the decline of this disease in our country.

Comparison between Three Rare Cases of Co-Infection with Dengue, Leptospira and Hepatitis E: Is Early Endothelial Involvement the Culprit in Mortality?

Co-infection in immunocompetent patients is rare. Though co-infection with dengue and leptospira cases is increasingly reported, a co-infection of this combination along with hepatitis E is rarely thought of. Until date only two case of triple co-infection have been reported world-wide. Here, we are reporting a patient with co-infection of dengue, leptospirosis and hepatitis E admitted to our intensive care unit. Early septic shock and increasing procalcitonin in dengue patient raised suspicion of co-infection. Our aim is to educate intensivists about this rare co-infection and hence that timely initiation of appropriate diagnostic, therapeutic and supportive measures can alter outcome favorably.

Periampullary carcinoma in a patient with agenesis of dorsal pancreas.

Agenesis of dorsal pancreas is a rare developmental anomaly. We here report a case of agenesis of dorsal pancreas in a patient of periampullary carcinoma and highlight its implications on the management.

Giant lipoma of posterior neck with bleeding decubitus ulcer: a rare entity.

Giant lipomas are benign soft tissue tumours. They are found relatively rarely on the posterior part of the neck. Bleeding pressure ulcer in this giant tumour is a rare presentation. Surgical interventions in these tumours are very challenging because, sometimes, extension to the spinal cord and malignant change may occur, especially in old age. Knowledge of the anatomy and meticulous surgical techniques are needed for such giant lipomas.