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J Biochem Mol Toxicol ; 31(8)2017 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-28266775

RESUMEN

Estimating the ability of bone marrow-derived mesenchymal stem cells (BM-MSCs) to alleviate pulmonary injury induced via isoproterenol (ISP). ISP was injected in a dose of (100 mg/kg, subcutaneously twice at an interval of 24 h). One month post BM-MSCs transplantation by intravenous injection, pulmonary oxidative stress was assessed, and Western blot analyses and histopathological investigations were conducted. Compared with the normal control group, BM-MSCs transplantation significantly decreased the expression of pulmonary anti-oxidative stress marker. Western blot analysis revealed that ISP significantly reduced the protein expression of the anti-oxidative stress marker nuclear related factor-2 (Nrf2). However, the apoptotic marker (caspase-3) and collagen content marker (8-hydroxyproline) were markedly elevated. These biochemical markers were confirmed by histopathological investigations. Finally, it was demonstrated that BM-MSCs transplantation showed a superior effect in improving pulmonary function through alleviating oxidative stress, apoptosis, and collagen content.


Asunto(s)
Agonistas de Receptores Adrenérgicos beta 2/efectos adversos , Células de la Médula Ósea/metabolismo , Caspasa 3/metabolismo , Hidroxiprolina/metabolismo , Isoproterenol/efectos adversos , Lesión Pulmonar , Trasplante de Células Madre Mesenquimatosas , Agonistas de Receptores Adrenérgicos beta 2/farmacología , Aloinjertos , Animales , Biomarcadores/metabolismo , Isoproterenol/farmacología , Lesión Pulmonar/inducido químicamente , Lesión Pulmonar/metabolismo , Lesión Pulmonar/terapia , Masculino , Factor 2 Relacionado con NF-E2/metabolismo , Ratas
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