The course of COVID-19 in patients with hematological malignancies and risk factors affecting mortality: A cross-sectional study.

Objective: This study aimed to determine the clinical outcomes and risk factors affecting mortality in patients with COVID-19 following hematological malignancy (HM). Methods: Patients diagnosed with HM and hospitalized for COVID-19 were included in this retrospective study. The age, demographic and clinical characteristics, prognosis and treatment of surviving and non-surviving patients were compared. Results: A total of 49 patients were included in this study, 17 (34.6%) of whom died within 28 days of being diagnosed with COVID-19. Older age (p = 0.001), diabetes (p = 0.001), chronic obstructive pulmonary disease (p = 0.002), secondary infection (p < 0.001) and secondary bacterial infection (p = 0.005) were statistically significantly higher in non-survivors. The remission status of HM was higher in surviving patients (p < 0.001). In multivariate regression analysis, age (OR: 1.102, p = 0.035) and secondary infection (OR: 16.677, p = 0.024) were risk factors increasing mortality, the remission status of HM (OR: 0.093, p = 0.047) was a protective factor from mortality. Conclusion: The older age, the remission status of HM and secondary infection due to COVID-19 were determined as prognostic factors predicting mortality in HM patients with following COVID-19.

Retrospective analysis on efficacy of convalescent plasma in acute respiratory distress syndrome due to COVID-19

ABSTRACT BACKGROUND: Coronavirus disease 2019 (COVID-19) is an ongoing global health threat. However, currently, no standard therapy has been approved for the disease. OBJECTIVES: To evaluate the clinical effectiveness of convalescent plasma (CP) in patients with acute respiratory distress syndrome (ARDS) due to COVID-19. DESIGN AND SETTING: Retrospective study conducted at Kayseri City Education and Research Hospital, Kayseri, Turkey. METHODS: The case group consisted of adult patients (> 18 years) with ARDS due to COVID-19 who received CP in combination with antiviral and supportive treatment. These patients were compared with others who only received antiviral and supportive treatment. RESULTS: During the study period, a total of 30 patients with ARDS due to COVID-19 were included. Eleven patients (36%) received CP in combination with antiviral and supportive treatment, whereas nineteen patients (64%) in the control group only received antiviral and supportive treatment. On admission, the median age, demographic and clinical data and initial laboratory test results were similar between the groups (P > 0.05). On the 14th day of treatment, the laboratory values remained similar between the groups (P > 0.05). The mortality rates were not significantly different between the groups. CONCLUSION: CP treatment did not affect mortality or lead to clinical improvement for COVID-19 patients with ARDS.

Retrospective analysis on efficacy of convalescent plasma in acute respiratory distress syndrome due to COVID-19.

BACKGROUND: Coronavirus disease 2019 (COVID-19) is an ongoing global health threat. However, currently, no standard therapy has been approved for the disease. OBJECTIVES: To evaluate the clinical effectiveness of convalescent plasma (CP) in patients with acute respiratory distress syndrome (ARDS) due to COVID-19. DESIGN AND SETTING: Retrospective study conducted at Kayseri City Education and Research Hospital, Kayseri, Turkey. METHODS: The case group consisted of adult patients (> 18 years) with ARDS due to COVID-19 who received CP in combination with antiviral and supportive treatment. These patients were compared with others who only received antiviral and supportive treatment. RESULTS: During the study period, a total of 30 patients with ARDS due to COVID-19 were included. Eleven patients (36%) received CP in combination with antiviral and supportive treatment, whereas nineteen patients (64%) in the control group only received antiviral and supportive treatment. On admission, the median age, demographic and clinical data and initial laboratory test results were similar between the groups (P > 0.05). On the 14th day of treatment, the laboratory values remained similar between the groups (P > 0.05). The mortality rates were not significantly different between the groups. CONCLUSION: CP treatment did not affect mortality or lead to clinical improvement for COVID-19 patients with ARDS.

Effects of high incubation temperature on the body weight and yolk consumption of two commercial broiler strain

Background: Temperature is the most important factor controlling embryonic development. Hyper- and hypothermic effects depend on the degree of temperature, duration of exposure and the stage of the development. From the middle of incubation period, embryo temperature is greater than air temperature of the incubator because of the increased metabolic activity. Thus elevated temperature especially in the second half of incubation has a major impact on hatchability and chick quality. The aim of this work was to investigate and compare the effects of high incubation temperature applied from the 10th day to the end of incubation on the body weight and yolk consumption of Ross 308 and Hybro embryos.Materials, Methods & Results: In the experiment, a total of 500 eggs, 250 fertile eggs from each of Hybro and Ross 308 broiler strains were used. The eggs of each strain were weighed and then divided into 2 groups as control and high incubation temperature exposed (heat-stress) groups. The control eggs of both strains were maintained under optimal conditions (incubation temperature: 37.8o C) during the whole incubation period, whereas heat stress imposed eggs were maintained under 37.8o C until the 10th day of incubation and then continuously exposed to high temperature (38.8o C) in the incubator. Other environmental conditions were standardized. At the 11, 13, 15, 18, 20 and 21st days...(AU)

Effects of high incubation temperature on the body weight and yolk consumption of two commercial broiler strain

Background: Temperature is the most important factor controlling embryonic development. Hyper- and hypothermic effects depend on the degree of temperature, duration of exposure and the stage of the development. From the middle of incubation period, embryo temperature is greater than air temperature of the incubator because of the increased metabolic activity. Thus elevated temperature especially in the second half of incubation has a major impact on hatchability and chick quality. The aim of this work was to investigate and compare the effects of high incubation temperature applied from the 10th day to the end of incubation on the body weight and yolk consumption of Ross 308 and Hybro embryos.Materials, Methods & Results: In the experiment, a total of 500 eggs, 250 fertile eggs from each of Hybro and Ross 308 broiler strains were used. The eggs of each strain were weighed and then divided into 2 groups as control and high incubation temperature exposed (heat-stress) groups. The control eggs of both strains were maintained under optimal conditions (incubation temperature: 37.8o C) during the whole incubation period, whereas heat stress imposed eggs were maintained under 37.8o C until the 10th day of incubation and then continuously exposed to high temperature (38.8o C) in the incubator. Other environmental conditions were standardized. At the 11, 13, 15, 18, 20 and 21st days...