Oncocitoma de la carúncula: caso clínico / Oncocytoma of the caruncle: a case report

Caso clínico: Se presenta el caso de una mujer de 79 años con una pequeña lesión en el canto interno de su ojo derecho desde hacía 6 meses. Se procedió a la extirpación quirúrgica y análisis histológico de la lesión, con el diagnóstico de oncocitoma de carúncula. Discusión: Los oncocitomas oculares son neoplasias benignas raras que se localizan en la carúncula, conjuntiva, glándula lagrimal y saco lagrimal. Están compuestos de células que derivan de los epitelios glandulares. Aunque es infrecuente, este tumor debería conocerse, especialmente en personas mayores, ya que excepcionalmente puede progresar a adenocarcinoma (AU)

Case report: We describe a 79 year-old woman who had a small lesion on the inner corner of her right eye for the last 6 months. The lesion was surgically excised and histologically analysed, with a diagnosis of oncocytoma of the caruncle. Discussion: Ocular oncocytomas are rare benign neoplasms found in the caruncle, conjunctiva, lacrimal gland and lacrimal sac. They are composed of transformed epithelial cells of the ducts. Although rare, this tumour should be recognized especially in the elderly because of the exceptional development of adenocarcinoma (AU)

[Oncocytoma of the caruncle: a case report]. / Oncocitoma de la carúncula: caso clínico.

CASE REPORT: We describe a 79 year-old woman who had a small lesion on the inner corner of her right eye for the last 6 months. The lesion was surgically excised and histologically analysed, with a diagnosis of oncocytoma of the caruncle. DISCUSSION: Ocular oncocytomas are rare benign neoplasms found in the caruncle, conjunctiva, lacrimal gland and lacrimal sac. They are composed of transformed epithelial cells of the ducts. Although rare, this tumour should be recognized especially in the elderly because of the exceptional development of adenocarcinoma.

Síndromes poliglandulares autoinmunes / Polyglandular autounnybe syndrome

Los síndromes poliglandulares autoinmunes (SPA) agrupan enfermedades endocrinas y no endocrinas en un mismo paciente. Existen 4 tipos SPA (SPA 1, SPA 2, SPA 3 y SPA4), netamente diferenciados en orden a su frecuencia, edad de aparición, herencia, asociación con los genes del sistema HLA y agrupación de las enfermedades que los constituyen El síndrome IPEX asocia un fallo inmunitario con una poliendocrinopatía y una enteropatía de carácter autoinmune. Se comentan las características diferenciales, los hallazgos inmunogenéticos respectivos y se aboga por la necesidad de organizar estudios multicéntricos y protocolos de seguimiento en los pacientes sus familiares (AU)

The term Autoimmune Polyglandular Syndromes includes endocrine and not endocrine diseases which occurs in the same patient. There are four types of APS (APS 1, APS 2, APS 3 and APS 4) clearly differentiated by its frequency, age of presentation, association to HLA genes and the diseases included in each type. The syndrome IPEX includes immune dysregulation, autoimmune enteropathy and polyendocrinopaty autoimmune. Differential characteristics and inmunogenetic findings are discussed and, based on the recent advances, we support the need of organizing multicentric studies and protocols for the follow-up of patients and relatives (AU)

Paciente con hipertensión arterial y tumor renal / Patient with arterial hypertension and renal tumor

Los tumores renales son causantes de hipertensión arterial en un bajo porcentaje de casos. El más frecuentemente implicado es el feocromocitoma, aunque están descritos otros tumores. Uno de ellos es el hipernefroma, caso que a continuación se describe y que además utilizamos como ejemplo de cronoterapia

Renal tumors cause arterial hypertension in a low percentage of cases. The most frequently involved is pheochromocytoma, although other tumors are described. One of them is hypernephroma, a case is described in the following and is also used as an example of chronotherapy

[Herpes simplex keratitis following laser in situ keratomileusis]. / Queratitis por herpes simplex tras láser in situ keratomileusis.

CASE REPORT: A 40-year-old woman underwent bilateral Laser In Situ Keratomileusis (LASIK) for the correction of myopia and astigmatism. The day after, four dendritic ulcers appeared in her left eye. She was treated with topical antiviral agents until complete recovery. She had a history of recurrent labial herpetic infection. DISCUSSION: Reactivation of herpes simplex virus type 1 can occur, even without any previous history of corneal infection. Although this does not contraindicate surgery, all patients with a history of herpetic infection should be made aware of the complications related to this technique.

[Long-term development of children with Schönlein-Henoch purpura associated with anti-neutrophil cytoplasmic antibodies]. / Evolución a largo plazo de los niños con púrpura de Schönlein-Henoch asociada a anticuerpos anticitoplasma de neutrófilo (ANCA).

OBJECTIVE: The purpose of this study was to assess the frequency of antineutrophil cytoplamic antibodies (ANCA) in Schönlein-Henoch purpura (SHP) and its long-term significance. PATIENTS AND METHODS: IgG and IgA classes of ANCA were studied by indirect immunofluorescence (IIF) and IgG-ANCA against myeloperoxidase (MPO) and against proteinase-3 (PR-3) were determined by ELISA in 50 children with SHP. Eight (16%) of the patients had renal involvement during the acute phase, but none had a permanent nephropathy after a 7-17 year follow-up. RESULTS: Positive IgG ANCA were found in 5 (10%) of the cases and only one of these children also had IgA ANCA. The ELISA against MPO and P-3 was negative in all patients. None of the 5 patients with ANCA showed nephropathy during the acute phase nor relapses or permanent nephropathy. CONCLUSIONS: A minority of children with SHP are positive for ANCA and, in the absence of nephropathy, this is not associated with a bad long-term prognosis.

[Nephrotic syndrome in infancy: clinical, therapeutic and follow up characteristics in 100 cases]. / Síndrome nefrótico de la infancia: características clínicas, terapéuticas y evolutivas en 100 casos.

In order to understand the natural history, clinical features, anatomopathological findings and response to the initial treatment with steroids of the nephrotic syndrome (NS) during childhood, a group of 100 children under 14 years (46 with renal biopsy) observed for an average period of 4 years and 8 months, was reviewed retrospectively. The patients were divided into 3 groups: idopathic NC (89), secondary NS (9) and NS in the first six months of life (2). In the group of idiopathic NS, in which the significant predominance of males (2.8/1) was confirmed, in 69% of the patients the diagnosis was made between the ages of 2 and 5 years. Edemas were found, sometimes accompanied by oliguria and weigh gain, in 77% of the cases. The periods of hypertension and hematuria were infrequent and brief. Thirty eight kidney biopsies were carried out and showed: 25 minimal changes NS, 7 diffuse mesangial proliferative glomerulonephritis (DMPGN), 3 membranoproliferative glomerulonephritis (MPGN), 2 membranous glomerulonephritis (MGN) and 1 segmental and focal glomerulosclerosis. Of the 83 patients treated in first instance with corticosteroids, a positive response was obtained in 72 (87%), although 44% of them have shown to be cortico-dependent. After an average follow up period of 4 years and 8 months, only 2 children, one with MPGN and the other with MGN, are now in chronic renal failure (CRF). In 5 ot the 9 patients included in the second group, the NS was secondary to a Henoch Schönlein purpura. The kidney biopsies showed DMPGN in three of them.(ABSTRACT TRUNCATED AT 250 WORDS)